Prosecution Insights
Last updated: April 19, 2026
Application No. 18/276,585

BACTERIAL BIO-CONTROL AGENTS FOR IMPROVING PLANTS' GROWTH, YIELD AND RESISTANCE TO PATHOGENS

Non-Final OA §101§112
Filed
Aug 09, 2023
Examiner
KOLKER, DANIEL E
Art Unit
1645
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
The Agricultural Research Organization (Israel)
OA Round
1 (Non-Final)
50%
Grant Probability
Moderate
1-2
OA Rounds
4y 5m
To Grant
99%
With Interview

Examiner Intelligence

Grants 50% of resolved cases
50%
Career Allow Rate
121 granted / 243 resolved
-10.2% vs TC avg
Strong +65% interview lift
Without
With
+65.0%
Interview Lift
resolved cases with interview
Typical timeline
4y 5m
Avg Prosecution
39 currently pending
Career history
282
Total Applications
across all art units

Statute-Specific Performance

§101
3.3%
-36.7% vs TC avg
§103
32.4%
-7.6% vs TC avg
§102
20.5%
-19.5% vs TC avg
§112
24.3%
-15.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 243 resolved cases

Office Action

§101 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Applicants preliminary amendment filed August 9, 2023 has been received and entered. Claims 1-52 have been canceled and new claims 53-72 have been added. Accordingly, claims 53-72 are pending in the instant application. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. 1. Claims 53-72 are not directed to patent eligible subject matter. Based upon an analysis with respect to the claim as a whole, claim(s) 53-72 do not recite something significantly different than a judicial exception. The rationale for this determination is explained below: Claims 53-72 are directed to naturally occurring bacterial strains and methods for improving plant traits. The claims drawn to naturally occurring bacteria (55-62) and are not patent eligible merely because they have been isolated. Applicants specification (page 12, Example 1) sets forth that the bacterial strains of the instant invention were isolated from tomato leaf samples. Accordingly, the instant claims encompass naturally occurring bacteria and are thereby deemed to be a judicial exception. The Supreme Court in Diamond v. Chakrabarty, 447 U.S. 303, 206 USPQ 193 (1980), held a claim to a genetically engineered bacterium eligible, because the claimed bacterium was not a “product of nature” exception. (Emphasis added). As the Court explained, the modified bacterium was patentable because the patent claim was not to a “hitherto unknown natural phenomenon,” but instead had “markedly different characteristics from any found in nature,” due to the additional plasmids and resultant capacity for degrading oil. 447 U.S. at 309-10, 206 USPQ at 197. Subsequent judicial decisions have made clear that the Supreme Court’s decision in Chakrabarty is “central” to the eligibility inquiry with respect to nature-based products. See, e.g., Association for Molecular Pathology v. Myriad Genetics, Inc., 569 U.S. _, 133 S. Ct. 2107, 2116, 106 USPQ2d 1972, 1979 (2013). For example, the Federal Circuit has indicated that “discoveries that possess ‘markedly different characteristics from any found in nature,’ … are eligible for patent protection.” In re Roslin Institute (Edinburgh), 750 F.3d 1333, 1336, 110 USPQ2d 1668, 1671 (Fed. Cir. 2014) (quoting Chakrabarty, 447 U.S. at 310, 206 USPQ2d at 197). In Roslin, the claimed invention was a live-born clone of a pre-existing, non-embryonic, donor mammal selected from cattle, sheep, pigs, and goats. An embodiment of the claimed invention was the famous Dolly the Sheep, which the court stated was “the first mammal ever cloned from an adult somatic cell.” Despite acknowledging that the method used to create the claimed clones “constituted a breakthrough in scientific discovery”, the court relied on Chakrabarty in holding the claims ineligible because “Dolly herself is an exact genetic replica of another sheep and does not possess ‘markedly different characteristics from any [farm animals] found in nature.’” Roslin, 750 F.3d at 1337, 110 USPQ2d at 1671. As the bacterial strains remain identical to the naturally occurring bacteria isolated from tomato leaves, the instantly claimed microorganisms are deemed to be a naturally occurring judicial exception. Furthermore, Applicants method for improving a plant trait is likewise a naturally occurring process and judicial exception. As Applicants have isolated the claimed bacteria from tomato leaves, the combination of the claimed bacterial strains in the presence of a plant equally occurs in nature. Accordingly, Applicants claimed bacterial strains and method of improving plant traits is a naturally occurring process and judicial exception. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. 2. Claims 63-66 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claims 63-66 recite “The method of claim 60…” However, claim 60 is a bacterial formulation, not a method. Accordingly, one of skill in the art would be unable to determine the metes and bounds of the claimed invention. 3. Claims 57-62 are rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. Claim 57 (and dependent claims 58-62) recite “The bacterial formulation of claim 55 for use in improving a plant trait. (Emphasis added). If the body of a claim fully and intrinsically sets forth all of the limitations of the claimed invention, and the preamble merely states, for example, the purpose or intended use of the invention, rather than any distinct definition of any of the claimed invention's limitations, then the preamble is not considered a limitation and is of no significance to claim construction. Pitney Bowes, Inc. v. Hewlett-Packard Co., 182 F.3d 1298, 1305, 51 USPQ2d 1161, 1165 (Fed. Cir. 1999). Applicants recitation of “for use” in improving a plant trait is an intended use of the claimed composition. As the intended use does not further limit the composition (e.g., further comprising a carrier, excipient, etc.) the composition remains structurally identical in each of claims 57-62. Accordingly, claims 57-62 fail to further limit the bacterial composition recited in claim 55. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Mark NAVARRO whose telephone number is (571)272-0861. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Gary Nickol can be reached at 571 272-0835. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ALBERT M NAVARRO/Primary Examiner, Art Unit 1645 October 23, 2025
Read full office action

Prosecution Timeline

Aug 09, 2023
Application Filed
Oct 23, 2025
Non-Final Rejection — §101, §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12564620
TREATMENT OF GULF WAR ILLNESS
2y 5m to grant Granted Mar 03, 2026
Patent 12551459
A COMBINATION OF KYNURENINE AND ANTIGEN PRESENTING CELLS (APC) AS THERAPEUTICS AND METHODS FOR THEIR USE IN IMMUNE MODULATION
2y 5m to grant Granted Feb 17, 2026
Patent 12071478
ANTIBODY FOR TREATING AUTOIMMUNE DISEASES
2y 5m to grant Granted Aug 27, 2024
Patent 12048765
LIPOSOME-BASED IMMUNOTHERAPY
2y 5m to grant Granted Jul 30, 2024
Patent 11613585
NUCLEIC ACIDS ENCODING ANTAGONISTIC CD40 MONOCLONAL ANTIBODIES
2y 5m to grant Granted Mar 28, 2023
Study what changed to get past this examiner. Based on 5 most recent grants.

AI Strategy Recommendation

Get an AI-powered prosecution strategy using examiner precedents, rejection analysis, and claim mapping.
Powered by AI — typically takes 5-10 seconds

Prosecution Projections

1-2
Expected OA Rounds
50%
Grant Probability
99%
With Interview (+65.0%)
4y 5m
Median Time to Grant
Low
PTA Risk
Based on 243 resolved cases by this examiner. Grant probability derived from career allow rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month