DETAILED ACTION
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
According to paper filed on May 1, 2026, the applicants have canceled claims 22, 24, 25 and 30; amended claims 1, 3, 4, 6-8, 10-21, 23 and 26-29 and furthermore, have added a new claim 31.
Claims 1-21, 23, 26-29 and 31 are pending in the application.
Response to Arguments
Applicant's arguments filed May 1, 2026 have been fully considered but they are not persuasive regarding indefiniteness rejection of claim 26. The applicants have amended claims to overcome all other rejections. Regarding claim 26, the applicants argue on page 14 that POSITA would know from the disclosure and in view of common knowledge in the art regarding specific diseases mediated by HCN2. The examiner does not agree with these arguments since there may be enablement issues based on specific diseases mediated either by hyperactivity or hypoactivity of HCN2. Therefore, claim must include specific diseases mediated by either hyperactivity or hypoactivity of HCN2.
Conclusion
Rejection of claim 26 under 35 U.S.C. 112, 2nd paragraph is maintained.
Allowable Subject Matter
Claim 27 is objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims.
Claims 1-21, 23, 28-29 and 31 are allowed.
Any inquiry concerning this communication or earlier communications from the examiner should be directed to CHARANJIT AULAKH whose telephone number is (571)272-0678. The examiner can normally be reached Monday-Friday 7:00-3:30.
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If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Clinton A Brooks can be reached at 571-270-7682. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300.
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/CHARANJIT AULAKH/ Primary Examiner, Art Unit 1621
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