Office Action Predictor
Last updated: April 15, 2026
Application No. 18/280,158

Heteroaromatic Inhibitors of Cancer Metabolism

Non-Final OA §102§DP
Filed
Sep 01, 2023
Examiner
JACKSON, SHAWQUIA
Art Unit
1626
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Vanderbilt University
OA Round
1 (Non-Final)
78%
Grant Probability
Favorable
1-2
OA Rounds
2y 3m
To Grant
74%
With Interview

Examiner Intelligence

Grants 78% — above average
78%
Career Allow Rate
1410 granted / 1810 resolved
+17.9% vs TC avg
Minimal -3% lift
Without
With
+-3.4%
Interview Lift
resolved cases with interview
Typical timeline
2y 3m
Avg Prosecution
29 currently pending
Career history
1839
Total Applications
across all art units

Statute-Specific Performance

§101
2.0%
-38.0% vs TC avg
§103
7.1%
-32.9% vs TC avg
§102
19.3%
-20.7% vs TC avg
§112
52.2%
+12.2% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1810 resolved cases

Office Action

§102 §DP
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Claims 1-6, 10, 14-19, 21, 46-48, 52 and 53 are currently pending in the instant application. Applicants have amended claims 6, 10, 15, 16, 19, 21, 46-48 and 52 and canceled claims 7-9, 11-13, 20, 22-45 and 49-51 in an amendment filed on September 1, 2023. Claims 1, 4, 15-19, 21, 46-48, 52 and 53 are rejected and claims 2-3, 5, 6, 10 and 14 are objected in this Office Action. I. Priority The instant application is a 371 of PCT/US22/18391, filed on March 1, 2022 which claims benefit of US Provisional Application 63/155,226, filed on March 1, 2021. II. Information Disclosure Statement The information disclosure statement (IDS) submitted on September 1, 2023 is in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statement has been considered by the examiner. III. Rejections Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless - (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1, 4, 15-19, 21, 46-48, 52 and 53 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Manning, et al. (WO 2020/252353 A1) . The instant invention claims PNG media_image1.png 791 779 media_image1.png Greyscale The Manning, et al. reference teaches amino acid transport inhibitors such as PNG media_image2.png 134 267 media_image2.png Greyscale (See page 15, compound 47) wherein Ar1 is phenyl. This species of compound anticipates the genus compound of the instant invention, wherein the genus structure and its definitions are stated above. Double Patenting The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory obviousness-type double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); and In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on a nonstatutory double patenting ground provided the conflicting application or patent either is shown to be commonly owned with this application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. Effective January 1, 1994, a registered attorney or agent of record may sign a terminal disclaimer. A terminal disclaimer signed by the assignee must fully comply with 37 CFR 3.73(b). Claims 1, 4, 15-19, 21, 46-48, 52 and 53 are rejected on the ground of nonstatutory obviousness-type double patenting as being unpatentable over claims 1, 3, 5, 6, 7, 12, 13 and 18-26 of copending US application 17/618,829. This is a provisional obviousness-type double patenting rejection. Although the conflicting claims are not identical, they are not patentably distinct from each other because: Applicants’ elected subject matter is PNG media_image1.png 791 779 media_image1.png Greyscale Determining the Scope and Content of the Copending Application Claim 1 of the copending application claims PNG media_image3.png 819 786 media_image3.png Greyscale Ascertaining the Differences Between the Instant Application and the Copending Application The claims of the instant application are drawn to a narrower compound genus PNG media_image4.png 120 256 media_image4.png Greyscale that is encompassed by the broader compound genus PNG media_image5.png 79 186 media_image5.png Greyscale of the copending application’s claims. The copending application claims the species PNG media_image6.png 136 256 media_image6.png Greyscale which reads on the instant claimed compounds. Finding Prima Facie Obviousness As mentioned above, the genus compound of the copending application encompasses the narrower genus compound in the instant application’s claims 1, 4, 15-19, 21, 46-48, 52 and 53. The further limiting claim 19 in the copending application contains the species PNG media_image6.png 136 256 media_image6.png Greyscale which reads on the scope of the elected subject matter of the claims 1, 4, 15-19, 21, 46-48, 52 and 53 in the instant application. The scope of the compounds in the claims 1, 3, 5, 6, 7, 12, 13 and 18-26 of the copending application and the scope of the elected subject matter of claims 1, 4, 15-19, 21, 46-48, 52 and 53 of the instant application overlap and include subject matter of the copending application in the claims of the instant application. Therefore, one of ordinary skill in the art would be motivated to prepare and claim the scope of the compounds in the instant application since the scope already in the copending application is encompassed by the scope of the elected subject matter in the instant claims 1, 4, 15-19, 21, 46-48, 52 and 53. As a result, the claims are rejected under obviousness-type double patenting. IV. Objections Dependent Claim Objections Dependent Claims 2-3,5,6,10 and 14 are objected to as being dependent upon a rejected based claim. To overcome this objection, Applicant should rewrite said claims in an independent form and include the limitations of the base claim and any intervening claim. Claim Objections Claim 14 is objected to because of the following informalities: claim 14 should have the term “and” in between the last two structures listed in the claim. Appropriate correction is required. V. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to Shawquia Jackson whose telephone number is 571-272-9043. The examiner can normally be reached on 7:00 AM-3:30PM. If attempts to reach the examiner by telephone are unsuccessful, the examiner's supervisor, Joseph McKane can be reached on 571-272-0699. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). /SHAWQUIA JACKSON/ Primary Examiner, Art Unit 1626
Read full office action

Prosecution Timeline

Sep 01, 2023
Application Filed
Nov 23, 2025
Non-Final Rejection — §102, §DP
Mar 20, 2026
Response Filed

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12594265
METHODS AND COMPOSITIONS FOR INHIBITION OF STAT3
2y 5m to grant Granted Apr 07, 2026
Patent 12595231
NOVEL CRYSTALLINE SALT FORMS OF MESEMBRINE
2y 5m to grant Granted Apr 07, 2026
Patent 12590047
METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN
2y 5m to grant Granted Mar 31, 2026
Patent 12583818
NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF
2y 5m to grant Granted Mar 24, 2026
Patent 12576396
POLYNORBORNENE/CARBON BLACK-CROSS-LINKED THREE-DIMENSIONAL NETWORK-IMMOBILIZED COPPER/GOLD (PNBI/CB-Cu/Au) NANOCATALYST, AND PREPARATION METHOD AND USE THEREOF
2y 5m to grant Granted Mar 17, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

AI Strategy Recommendation

Get an AI-powered prosecution strategy using examiner precedents, rejection analysis, and claim mapping.
Powered by AI — typically takes 5-10 seconds

Prosecution Projections

1-2
Expected OA Rounds
78%
Grant Probability
74%
With Interview (-3.4%)
2y 3m
Median Time to Grant
Low
PTA Risk
Based on 1810 resolved cases by this examiner. Grant probability derived from career allow rate.

Sign in for Full Analysis

Enter your email to receive a magic link. No password needed.

Free tier: 3 strategy analyses per month