Prosecution Insights
Last updated: April 19, 2026
Application No. 18/281,125

QUINOXALINE UREA INHIBITORS OF IKK-BETA AND NF-KB

Non-Final OA §102§DP
Filed
Sep 08, 2023
Examiner
SAEED, KAMAL A
Art Unit
1626
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
OA Round
1 (Non-Final)
84%
Grant Probability
Favorable
1-2
OA Rounds
2y 3m
To Grant
93%
With Interview

Examiner Intelligence

Grants 84% — above average
84%
Career Allow Rate
1007 granted / 1194 resolved
+24.3% vs TC avg
Moderate +9% lift
Without
With
+9.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 3m
Avg Prosecution
16 currently pending
Career history
1210
Total Applications
across all art units

Statute-Specific Performance

§101
1.4%
-38.6% vs TC avg
§103
11.5%
-28.5% vs TC avg
§102
9.4%
-30.6% vs TC avg
§112
19.3%
-20.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1194 resolved cases

Office Action

§102 §DP
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claims 5, 11-13, 16-18, 21, 22, 24, 25, 27-29, 31, 32, 34, 36-48, and 51-55 are cancelled. Therefore, claims 1-4, 6-10, 14, 15, 19, 20, 23, 26, 30, 33,35, 49 and 50 are currently pending in this Application. Priority CONTINUING DATA This application is a 371 of PCT/US2022/019467 03/09/2022 PCT/US2022/019467 has PRO of 63249312 09/28/2021 PCT/US2022/019467 has PRO of 63158486 03/09/2021 Information Disclosure Statement Applicant’s Information Disclosure Statements, filed on March 06, 2024 and February 11, 2025 has been considered. Please refer to Applicant’s copies of the 1449 submitted herewith. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a) the invention was known or used by others in this country, or patented or described in a printed publication in this or a foreign country, before the invention thereof by the applicant for a patent. (b) the invention was patented or described in a printed publication in this or a foreign country or in public use or on sale in this country, more than one year prior to the date of application for patent in the United States. Claims 1-4, 6-10, 14, 15, 19, 20, 23, 26, 30, 33, 35, 49 and 50 are rejected under 35 U.S.C. 102(a) as being anticipated by WO 2019/109069 A1 published June 06, 2019. The US equivalent is US Patent No. 11,661,441. The instant invention is drawn to quinoxaline urea products of Formula I, PNG media_image1.png 98 270 media_image1.png Greyscale as defined in claim 1. The dependent claim further limit the variables recited in Formula I. Claims 49 and 50 are drawn to method of use of products of the aforementioned products. WO 2019/109069 A1 teach quinoxaline urea products of Formula PNG media_image2.png 100 320 media_image2.png Greyscale and specific species that read on the products of the instant invention. Please, see the following: PNG media_image3.png 264 725 media_image3.png Greyscale WO 2019/109069 A1 also teach the same method of use as claimed in claims 49 and 50. See paragraph [0036] PNG media_image4.png 317 793 media_image4.png Greyscale Double Patenting The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP §§ 706.02(l)(1) - 706.02(l)(3) for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/process/file/efs/guidance/eTD-info-l.jsp. Claims 1-4, 6-10, 14, 15, 19, 20, 23, 26, 30, 33, 35, 49 and 50 are rejected on the ground of nonstatutory obviousness-type double patenting as being unpatentable over claims 1-18 of U.S. Patent No. 11,661,411, commonly assigned. An obviousness-type double patenting rejection is appropriate where the conflicting claims are not identical, but an examined application claim is not patentably distinct from the reference claims because the examined claims are either anticipated by, or would have been obvious over, the reference claims. Although the conflicting claims are not identical, they are not patentably distinct from each other because both sets of claims are directed to the same art specific subject matter. The subject matter claimed in the instant application is fully disclosed in the patent and is covered by the patent since the patent and the application are claiming common subject matter, as follows: quinoxaline urea products of Formula I, PNG media_image1.png 98 270 media_image1.png Greyscale as defined in claim 1. The difference between the instant and the copending claims is in scope only. The claims are not identical, but there is significant overlap of subject matter. Furthermore, it should be noted that the variables in the formula of the patented claims have significant overlap, if not identical, to the instant corresponding variables. MPEP 804 states : “where the claims of an application are not the "same” as those of the first patent, but the grant of a patent with the claims in the application would unjustly extend the rights granted by the first patent, a double patenting rejection under nonstatutory grounds is proper.” Although the conflicting claims are not identical, the Examiner finds that a person having ordinary skill in the art would recognize that the claimed invention would unjustly extend the rights granted to U.S. Patent No. 11,661,411, because a hypothetical infringer of U.S. Patent No. 11,661,411 would necessarily be an infringer of the claimed invention. Accordingly, U.S. Patent No. 11,661,411 renders the instant claims obvious absent a showing of unpredictability or comparative evidence suggesting otherwise. Telephone Inquiry Any inquiry concerning this communication or earlier communications from the examiner should be directed to Kamal A Saeed whose telephone number is (571)272-0705. The examiner can normally be reached Monday-Friday 9:00a-5:00p. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Adam C Milligan can be reached at (571)270-7674. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /Kamal A Saeed/ Primary Examiner, Art Unit 1626
Read full office action

Prosecution Timeline

Sep 08, 2023
Application Filed
Jan 23, 2026
Non-Final Rejection — §102, §DP (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
84%
Grant Probability
93%
With Interview (+9.0%)
2y 3m
Median Time to Grant
Low
PTA Risk
Based on 1194 resolved cases by this examiner. Grant probability derived from career allow rate.

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