DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA. Claim Rejections - 35 USC § 103 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis ( i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status . The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. Claim (s) 7-9 is/are rejected under 35 U.S.C. 103 as being unpatentable over Moscosa-Santillan et al. (Chemical Engineering Science, 2000) . The instant claims are drawn to a crystallizer for a reduced coenzyme Q10 Form II crystal, comprising: The examiner would like to point out that the instant claims are being interpreted as a device/apparatus . To that end, Moscosa-Santillan et al. teach an experimental setup comprising a crystallizer (A), a thermometric probe (G), i.e., a temperature adjustment unit, a turbidimeter probe (H), i.e., a turbidity detection unit, and a programmable logic controller (O), i.e., a control unit (Fig. 1, p. 3761). The experimental setup taught by the reference differs from the crystallizer of the instant claims, as it contains additions elements not recited by the instant claims, for example, a stirrer, a volumetric pump, and balance . However, the instant claims recite a crystallizer “comprising” the named elements . Such open-ended language does not preclude the presence of additional elements that may make up the claimed device. Since the claims are being interpreted as a device, limitations of claims 8 and 9, that refer to specific parameters chosen within the device are not given much patentable weight, as they do not further limit the device itself . Accordingly, the instant claims are rendered obvious by the device taught by Moscosa-Santillan et al. Allowable Subject Matter The following is a statement of reasons for the indication of allowable subject matter: claims 1-6 and 10-15 are drawn to a method for producing a reduced coenzyme Q10 Form II crystal . The closest prior art, U.S. 2021/0317057, teaches a method for producing reduced coenzyme Q10 Form II crystal by adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a mixed solution containing an alcohol, at a specific temperature range, and precipitating a reduced coenzyme Q10 Form II crystal after adding the seed crystal . The closest prior art does not teach or suggest a method as claimed, wherein the precipitating comprising controlling the temperature based on a turbidity change rate obtained by a turbidity detection unit . Applicants have shown that the claimed method affords a reduced coenzyme Q10 Form II crystal having a higher oxidation stability compared to crystals form exclusively by controlling the temperature, as taught by the closest prior art. Any inquiry concerning this communication or earlier communications from the examiner should be directed to FILLIN "Examiner name" \* MERGEFORMAT SIKARL A WITHERSPOON whose telephone number is FILLIN "Phone number" \* MERGEFORMAT (571)272-0649 . The examiner can normally be reached FILLIN "Work Schedule?" \* MERGEFORMAT M-F 9am-9pm IFP . Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, FILLIN "SPE Name?" \* MERGEFORMAT Scarlett Goon can be reached at FILLIN "SPE Phone?" \* MERGEFORMAT 571-270-5241 . The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /SIKARL A WITHERSPOON/ Primary Examiner, Art Unit 1692