Prosecution Insights
Last updated: May 04, 2026
Application No. 18/292,686

Aqueous Hypochlorite Disinfectant Solution With Good Stability And Anti-Microbial Activity And Its Use

Non-Final OA §103§112
Filed
Jan 26, 2024
Priority
Jul 29, 2021 — CN 202110867697.2 +1 more
Examiner
SAEED, ALI S
Art Unit
1616
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Fresenius Medical Care
OA Round
1 (Non-Final)
30%
Grant Probability
At Risk
1-2
OA Rounds
1y 8m
Est. Remaining
64%
With Interview

Examiner Intelligence

Grants only 30% of cases
30%
Career Allowance Rate
34 granted / 113 resolved
-29.9% vs TC avg
Strong +33% interview lift
Without
With
+33.4%
Interview Lift
resolved cases with interview
Typical timeline
3y 11m
Avg Prosecution
65 currently pending
Career history
178
Total Applications
across all art units

Statute-Specific Performance

§101
0.9%
-39.1% vs TC avg
§103
46.1%
+6.1% vs TC avg
§102
7.8%
-32.2% vs TC avg
§112
21.8%
-18.2% vs TC avg
Black line = Tech Center average estimate • Based on career data from 113 resolved cases

Office Action

§103 §112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Priority This application is a National Stage entry of PCT/CN2022/107811, filed 07/26/2022, and claims foreign priority to CN202110867697.2, filed 07/29/2021. Information Disclosure Statement The IDS filed on 5/1/2024 has been considered. See the attached PTO 1449 form. Claim Status Claims 12-31 are currently pending and presented for examination on the merits for patentability. Claim Objections Claim 12 is objected to because of the following informalities: In claim 12, line 5, the recitation “0.001 wt% 4.0 wt%” should recite “0.001 wt% to 4.0 wt%”. Appropriate correction is required. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 20-24 and 28-30 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claims 20, 23-24 and 28 recite “the one or more salts of a phosphate compound”. There is insufficient antecedent basis for this limitation in the claim and this makes it unclear as to what components in the previous claims the one or more salts of a phosphate compound is referring to. Specifically, independent claims 12 and 25 recite one or more salts of a phosphoric acid compound. It is unclear whether the one or more salts of a phosphate compound (in claims 20, 23-24, 28) is referring to the one or more salts of a phosphoric acid compound recited in independent claims 12 and 25 or whether the one or more salts of a phosphate compound is different from the one or more salts of a phosphoric acid compound. Claim 23 recites the one or more salts of a phosphate compound has a salt content of 0.01 wt% to 3.5 wt% and claim 24 recites the one or more salts of a phosphate compound has a salt content of 0.1 wt% to 1.0 wt%. It is unclear whether the salt content concentrations (wt%) recited in these claims are directed to concentration of the phosphate compound (e.g. potassium tripolyphosphate) in the disinfectant solution because phosphate is a salt of phosphoric acid, or whether the salt content refers to the concentration of potassium in the potassium tripolyphosphate because the claim recites the salt of a phosphate compound has a salt content. Claims 21, 22, 29 and 30 are included in the rejection as they depend on a rejected base claim and do not clarify the issues discussed above. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. Claim 30 is rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. Claim 30 recites the sodium hypochlorite is present at a concentration of 2.5 wt% to 2.8 wt%. Claim 30 depends from claim 25 and claim 25 recites 30 g/L (i.e. 3%) to 40 g/L (i.e. 4%) of a hypochlorite. Concentration of 2.5% to 2.8% is outside the range recited in claim 30 (i.e. 3% to 4%), therefore, claim 30 improperly broadens the subject matter of independent claim 25. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. Claim Rejections - 35 USC § 103 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. This application currently names joint inventors. In considering patentability of the claims the examiner presumes that the subject matter of the various claims was commonly owned as of the effective filing date of the claimed invention(s) absent any evidence to the contrary. Applicant is advised of the obligation under 37 CFR 1.56 to point out the inventor and effective filing dates of each claim that was not commonly owned as of the effective filing date of the later invention in order for the examiner to consider the applicability of 35 U.S.C. 102(b)(2)(C) for any potential 35 U.S.C. 102(a)(2) prior art against the later invention. Claims 12-31 are rejected under 35 U.S.C. 103 as being unpatentable over Li et al. (CN1076081A; 1993-09-15). Li throughout the reference teaches disinfectant formulations used for sterilization/disinfection of clinical surgical instrument (medical device). Li teaches the formulation is a disinfectant aqueous solution. The disinfectant comprises hypochlorite at concentration of 0.5-2% by weight (i.e. 5 g/L to 20 g/L). Li teaches hypochlorite can include sodium hypochlorite or potassium hypochlorite. Sodium hydroxide or potassium hydroxide is included at concentration of 1-5% by weight. Potassium tripolyphosphate is also included at concentration of 2-10% by weight. (see English Translation of Li: abstract; pages 1-6; Examples; claims; entire document). While Li does not explicitly exemplify the claimed concentrations of hypochlorite, metal hydroxides and salts of phosphoric acid, Li does disclose a general range of concentrations which overlap or merely overlap the claimed concentrations. A prima facie case of obviousness exists where the claimed ranges or amounts do not overlap with the prior art but are merely close. Titanium Metals Corp. of America v. Banner, 778 F.2d 775, 783, 227 USPQ 773, 779 (Fed. Cir. 1985) (Court held as proper a rejection of a claim directed to an alloy of "having 0.8% nickel, 0.3% molybdenum, up to 0.1% iron, balance titanium" as obvious over a reference disclosing alloys of 0.75% nickel, 0.25% molybdenum, balance titanium and 0.94% nickel, 0.31% molybdenum, balance titanium. "The proportions are so close that prima facie one skilled in the art would have expected them to have the same properties."). In re Aller, 220 F.2d 454, 456, 105 USPQ 233, 235 (CCPA 1955) (Claimed process which was performed at a temperature between 40°C and 80°C and an acid concentration between 25% and 70% was held to be prima facie obvious over a reference process which differed from the claims only in that the reference process was performed at a temperature of 100°C and an acid concentration of 10%). See: MPEP 2144.05(I). Further, Li teaches Hypochlorite acts as a disinfectant and sterilizing agent. The addition of sodium hydroxide or potassium hydroxide is mainly used to adjust the pH of the disinfectant aqueous solution. Polyphosphates, such as sodium tripolyphosphate and potassium tripolyphosphate, act as a corrosion inhibitor. (see e.g. pages 2-3). Thus, absence any evidence of criticality of the claimed concentrations, it would have been obvious to one skilled in the art to optimize the concentrations of hypochlorite, metal hydroxides and salts of phosphoric acid to achieve these parameters disclosed by Li. Generally, differences in concentration or temperature will not support the patentability of subject matter encompassed by the prior art unless there is evidence indicating such concentration or temperature is critical. "[W]here the general conditions of a claim are disclosed in the prior art, it is not inventive to discover the optimum or workable ranges by routine experimentation." In re Aller, 220 F.2d 454, 456, 105 USPQ 233, 235 (CCPA 1955). From the combined teaching of the cited reference, one of ordinary skill in the art would have had a reasonable expectation of success in producing the claimed invention. Therefore, the invention, as a whole, would have been prima facie obvious to one of ordinary skill in the art. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to ALI SAEED whose telephone number is (571)272-2371. The examiner can normally be reached M-F 8-5 EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, SUE X LIU can be reached at 5712725539. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ALI S SAEED/Examiner, Art Unit 1616
Read full office action

Prosecution Timeline

Jan 26, 2024
Application Filed
Apr 01, 2026
Non-Final Rejection — §103, §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12599694
SCAFFOLD WOUND DRESSING
4y 0m to grant Granted Apr 14, 2026
Patent 12564192
HERBICIDAL AGENT COMPOSITION AND WEED CONTROL METHOD
4y 0m to grant Granted Mar 03, 2026
Patent 12485161
COMPOSITIONS COMPRISING SULFORAPHANE OR A SULFORAPHANE PRECURSOR AND A MILK THISTLE EXTRACT OR POWDER
3y 11m to grant Granted Dec 02, 2025
Patent 12446574
ADJUVANTS FOR AGROCHEMICAL FORMULATIONS
6y 4m to grant Granted Oct 21, 2025
Patent 12426596
WOOD PRESERVATIVES
4y 6m to grant Granted Sep 30, 2025
Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.
Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2
Expected OA Rounds
30%
Grant Probability
64%
With Interview (+33.4%)
3y 11m (~1y 8m remaining)
Median Time to Grant
Low
PTA Risk
Based on 113 resolved cases by this examiner. Grant probability derived from career allowance rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month