Prosecution Insights
Last updated: April 19, 2026
Application No. 18/297,504

METHODS FOR OPERATING A BIOREACTOR WITH IMPELLER ASSEMBLY AND RELATED BIOREACTORS

Final Rejection §103
Filed
Apr 07, 2023
Examiner
SORKIN, DAVID L
Art Unit
1774
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Life Technologies Corporation
OA Round
2 (Final)
67%
Grant Probability
Favorable
3-4
OA Rounds
3y 2m
To Grant
80%
With Interview

Examiner Intelligence

Grants 67% — above average
67%
Career Allow Rate
787 granted / 1170 resolved
+2.3% vs TC avg
Moderate +12% lift
Without
With
+12.5%
Interview Lift
resolved cases with interview
Typical timeline
3y 2m
Avg Prosecution
43 currently pending
Career history
1213
Total Applications
across all art units

Statute-Specific Performance

§101
0.6%
-39.4% vs TC avg
§103
32.7%
-7.3% vs TC avg
§102
32.8%
-7.2% vs TC avg
§112
27.1%
-12.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1170 resolved cases

Office Action

§103
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Rejections - 35 USC § 103 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. Claims 1-13 are rejected under 35 U.S.C. 103 as being unpatentable over Watkins (US 4. 2010/0149907). Regarding claims 1 and 2, Watkins discloses a method for operating a bioreactor comprising passing a drive shaft (22) into a first tubular connector (18) and a second tubular connector (34 or 38) projecting from the first tubular connector (see Fig. 3), the first tubular connector and the second tubular connector being at least partially disposed within a container (12), the first tubular connector being more flexible than the second tubular connector (see [0030]). The relative lengths of the connectors are not numerically stated; however, the discussions of length in [0023], [0029] and [0044] would have suggested finding a workable length ratio range to one of ordinary skill in the art before the effective filing date. Regarding claims 3 and 4, mixing elements (blades of 36) are disposed on the second tubular connector, but are not disclosed to be removable from them tubular connector. See In re Dulberg, 289 F.2d 522, 523, 129 USPQ 348, 349 (CCPA 1961) concerning the obviousness of making parts removable. It would have been obvious to one of ordinary skill in the art to have made the mixing elements removable to facilitate, repair, cleaning, assembly and/or disassembly. Regarding claim 5, the first tubular connector is comprised of an elastomeric material (see [0040]) and the second tubular connector is not comprised of elastomeric material (see [0039]). Regarding claim 6, Watkins discloses a method for operating a bioreactor, comprising passing a drive shaft (18) into a tubular member (38, and optionally 22 and/or 34) that is at least partially disposed within a container (12), a first mixing element (36) being disposed on the tubular member so that first mixing element encircles the tubular member; and rotating the drive shaft so as to rotate the tubular member and the first mixing element within the container. Regarding claim 7, the mixing element is not disclosed to be removable from them tubular connector. See In re Dulberg, 289 F.2d 522, 523, 129 USPQ 348, 349 (CCPA 1961) concerning the obviousness of making parts removable. It would have been obvious for one of ordinary skill in the art before the effective filing date to have made the mixing element removable to facilitate, repair, cleaning, assembly and/or disassembly. Regarding claim 8, while blades are disclosed, it also would have been obvious for one of ordinary skill in the art before the effective filing date to have duplicated the entire set of blades, to improve mixing. See also In re Harza, 274 F.2d 669, 124 USPQ 378 (CCPA 1960) concerning the obviousness of duplicating parts. Regarding claim 9, the tubular member comprises a first tubular connector (18) and a second tubular connector (38) projecting from the first tubular connector. Regarding claim 10, the first tubular connector is more flexible than the second tubular connector (see [0030]). Regarding claims 11 and 12, one of ordinary skill in the art before the effective filing date would have understood from [0023], [0029] and [0044] and Fig. 3 to have discovered optimal or workable ranges for these recited numerical parameters. Regarding claim 13, the drive shaft is linear (see Fig. 3). Response to Arguments Applicant presents arguments concerning independent claim 1, but not concerning independent claim 6. Particularly, applicant argues that the “projecting from” limitation of independent claim 1 is not disclosed by Watkins; however, there is no corresponding limitation in independent claim 6 and applicant does not mention independent claim 6 at all other than acknowledging that claims 1-13 are rejected. Concerning the “projecting from” limitation of claim 1, the rejection is primarily based upon the embodiment of Fig. 3 of Watkins. Contrary to applicant’s remarks, tubular connector 34 couples to tubular connector 18 via 35, and extends upwardly away from 18, thereby projecting from 18. Likewise, tubular connector 38 couples to tubular connector 18 via 42 and extends downwardly away from 18, thereby projecting from 18. Conclusion THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to DAVID L SORKIN whose telephone number is (571)272-1148. The examiner can normally be reached 7am-3:30pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Claire X Wang can be reached at (571) 270-1051. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. DAVID L. SORKIN Examiner Art Unit 1774 /DAVID L SORKIN/Primary Examiner, Art Unit 1774
Read full office action

Prosecution Timeline

Apr 07, 2023
Application Filed
Aug 11, 2025
Non-Final Rejection — §103
Dec 15, 2025
Response Filed
Jan 05, 2026
Final Rejection — §103
Apr 08, 2026
Request for Continued Examination
Apr 10, 2026
Response after Non-Final Action

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12600060
DEVICE FOR PRODUCING AND CONDITIONING A MULTI-COMPONENT MIXTURE AND METHOD FOR OPERATING A DEVICE OF THIS KIND
2y 5m to grant Granted Apr 14, 2026
Patent 12599881
MIXER
2y 5m to grant Granted Apr 14, 2026
Patent 12599879
NANO CELL BLOCK MODULE FOR HOMOGENIZING A SOLUTION WITH A HIGH PRESSURE
2y 5m to grant Granted Apr 14, 2026
Patent 12594532
FOAM PITCHER
2y 5m to grant Granted Apr 07, 2026
Patent 12596312
TONER PROCESSING APPARATUS AND METHOD FOR PRODUCING TONER
2y 5m to grant Granted Apr 07, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
67%
Grant Probability
80%
With Interview (+12.5%)
3y 2m
Median Time to Grant
Moderate
PTA Risk
Based on 1170 resolved cases by this examiner. Grant probability derived from career allow rate.

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