Prosecution Insights
Last updated: April 19, 2026
Application No. 18/310,465

SCREENING, MONITORING, AND TREATMENT FRAMEWORK FOR FOCUSED ULTRASOUND

Non-Final OA §112
Filed
May 01, 2023
Examiner
NGUYEN, HIEN NGOC
Art Unit
3797
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
West Virginia University
OA Round
3 (Non-Final)
52%
Grant Probability
Moderate
3-4
OA Rounds
4y 2m
To Grant
92%
With Interview

Examiner Intelligence

Grants 52% of resolved cases
52%
Career Allow Rate
403 granted / 767 resolved
-17.5% vs TC avg
Strong +40% interview lift
Without
With
+39.8%
Interview Lift
resolved cases with interview
Typical timeline
4y 2m
Avg Prosecution
62 currently pending
Career history
829
Total Applications
across all art units

Statute-Specific Performance

§101
6.5%
-33.5% vs TC avg
§103
49.9%
+9.9% vs TC avg
§102
10.8%
-29.2% vs TC avg
§112
24.7%
-15.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 767 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Continued Examination Under 37 CFR 1.114 A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on 11/03/25 has been entered. Claim Rejections - 35 USC § 112 The following is a quotation of the first paragraph of 35 U.S.C. 112(a): (a) IN GENERAL.—The specification shall contain a written description of the invention, and of the manner and process of making and using it, in such full, clear, concise, and exact terms as to enable any person skilled in the art to which it pertains, or with which it is most nearly connected, to make and use the same, and shall set forth the best mode contemplated by the inventor or joint inventor of carrying out the invention. The following is a quotation of the first paragraph of pre-AIA 35 U.S.C. 112: The specification shall contain a written description of the invention, and of the manner and process of making and using it, in such full, clear, concise, and exact terms as to enable any person skilled in the art to which it pertains, or with which it is most nearly connected, to make and use the same, and shall set forth the best mode contemplated by the inventor of carrying out his invention. Claims 1-25 are rejected under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, as failing to comply with the written description requirement. The claim(s) contains subject matter which was not described in the specification in such a way as to reasonably convey to one skilled in the relevant art that the inventor or a joint inventor, or for applications subject to pre-AIA 35 U.S.C. 112, the inventor(s), at the time the application was filed, had possession of the claimed invention. The specification insufficiently discloses how ultrasound treatment is determined to be appropriate for the patient to treat a disorder by screening a patient. No art rejection Response to Arguments Applicant's arguments filed 11/03/25 have been fully considered but they are not persuasive. Applicant argues it is clear that the inventors were in possession of the invention for the listed disorders using the claimed predictive model, with the specified output and training and therefore respectfully requested that this rejection be withdrawn. Applicant argues the specification describe predictive model, inputs, outputs and training process in ample detail to demonstrate to one of skill in the art that the inventors were in possession of the claimed invention at the time of filing. Applicant’s argument is not persuasive because the amendment does not address the issue raise by examiner. Examiner raised questions “how does screening for Parkinson make ultrasound appropriate for treatment? Does screening determine that a patient has pain, or addiction or Parkinson then use ultrasound treatment? If the screening indicates the patient don't have pain, addition or Parkinson then don't use ultrasound treatment? Pain, addiction and Parkinson can be treated by many other ways. As see in applicant’s specification paragraph [0065] there are other alternative treatment such as medications, transcranial magnetic stimulation, deep brain stimulation, biologicals, surgical intervention, changes of settings for an existing spinal cord stimulator, behavioral and social intervention, digital intervention via a portable device, mindfulness approaches, social media approaches, a care provider coming to the individual, directing an individual to go to a clinic, emergency room, or hospital, or directing the user to obtain additional testing. The specification does not disclose or provide examples how predictive model determine that ultrasound treatment is appropriate instead of using other treatment. The claims can overcome 112 rejection by having the specification discloses how predictive model determine that ultrasound treatment is appropriate instead of using other treatments and possibly having this information in the claims. Examiner consider “predictive model” to be a black box because the specification does not disclose how predictive model determine that ultrasound treatment is appropriate instead of using other treatments. The specification basically discloses having inputs (extracted features) into the predictive model (black box) then out the outputs that indicate use ultrasound for treatment or other treatments without describe sufficiently how predictive model (black box) able to determine that. The specification only discloses the type of algorithms use for predictive model and train model. Conclusion The prior art made of record and not relied upon is considered pertinent to applicant's disclosure. US 2018/0253840; US 2017/0203103; US 2015/0223877; US 2012/0265547; US 2009/0284378; US 2009/0157058; 2008/0004672; US 2010/0125206 (see [0008] and [0023]; predicting whether ultrasound insonation is likely to be effective in treating the symptoms of small vessel occlusion); US 2019/0307427 (see [0025]) and US 2018/0181704 (see [0189]). Any inquiry concerning this communication or earlier communications from the examiner should be directed to HIEN NGOC NGUYEN whose telephone number is (571)270-7031. The examiner can normally be reached Monday-Thursday 8:30am-6:30pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Keith Raymond can be reached at (571)270-1790. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /HIEN N NGUYEN/ Primary Examiner Art Unit 3793
Read full office action

Prosecution Timeline

May 01, 2023
Application Filed
Feb 11, 2025
Non-Final Rejection — §112
Mar 06, 2025
Interview Requested
Mar 20, 2025
Applicant Interview (Telephonic)
Mar 20, 2025
Examiner Interview Summary
May 02, 2025
Response Filed
Jun 30, 2025
Final Rejection — §112
Oct 02, 2025
Response after Non-Final Action
Nov 03, 2025
Request for Continued Examination
Nov 10, 2025
Response after Non-Final Action
Jan 27, 2026
Non-Final Rejection — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

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2y 5m to grant Granted Mar 10, 2026
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2y 5m to grant Granted Mar 03, 2026
Patent 12558574
METHOD AND SYSTEM FOR PARAMETERISING A HIGH-INTENSITY FOCUSED ULTRASOUND TREATMENT DEVICE
2y 5m to grant Granted Feb 24, 2026
Patent 12551729
MULTI-BEAM NEUROMODULATION TECHNIQUES
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Patent 12543959
DEVICE, SYSTEM AND METHOD FOR MONITORING OF PERIPHERAL ARTERIAL PERFUSION OF A SUBJECT
2y 5m to grant Granted Feb 10, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
52%
Grant Probability
92%
With Interview (+39.8%)
4y 2m
Median Time to Grant
High
PTA Risk
Based on 767 resolved cases by this examiner. Grant probability derived from career allow rate.

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