Prosecution Insights
Last updated: August 16, 2026
Application No. 18/317,241

ANTI-LAG3 ANTIBODIES AND USES THEREOF

Final Rejection §DP
Filed
May 15, 2023
Priority
Oct 09, 2015 — provisional 62/239,524 +6 more
Examiner
OUSPENSKI, ILIA I
Art Unit
1644
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Regeneron Pharmaceuticals Inc.
OA Round
2 (Final)
78%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
98%
With Interview

Examiner Intelligence

Grants 78% — above average
78%
Career Allowance Rate
868 granted / 1120 resolved
+17.5% vs TC avg
Strong +20% interview lift
Without
With
+20.4%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
41 currently pending
Career history
1160
Total Applications
across all art units

Statute-Specific Performance

§101
3.8%
-36.2% vs TC avg
§103
9.5%
-30.5% vs TC avg
§102
20.4%
-19.6% vs TC avg
§112
38.2%
-1.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1120 resolved cases

Office Action

§DP
DETAILED ACTION 1. The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . 2. Applicant's amendment and remarks filed on 07/02/2026 are acknowledged. Claims 57-64 are pending. 3. The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP §§ 706.02(l)(1) - 706.02(l)(3) for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/process/file/efs/guidance/eTD-info-I.jsp. 4. Claims 57-64 stand rejected on the ground of nonstatutory double patenting as being unpatentable over the claims of U.S. Patents No. 10358495, 11692032, 10905784, 11511001, and 12230364 (all of record) for the reasons of record. Applicant has not substantively addressed the grounds of rejection over the claims of US ‘495 and ‘032, presented in section 7 of the previous office action, which are therefore maintained. Applicant argues, citing Ex parte Baurin, that US ‘784, ‘001 and ‘364 patents do not qualify as NSDP references to the present application because they have later filing dates. Applicant also asserts that US ‘784 and ‘364 have later expiration dates. In response, it is noted that the examiner has no authority to interpret case law other than as prescribed by the MPEP. MPEP § 804 provides decision charts for examiners to follow, to determine whether an NSDP rejection should be made, which do not instruct examiners to consider any dates associated with the subject application or the reference patents. MPEP Form Paragraph 8.33, cited in section 3 above, identifies two goals of the judicially created doctrine of NSDP: prevention of unjustified or improper extension of patent rights and prevention of possible harassment by multiple assignees. Both goals must be met to overcome the rejection. Further, Applicant’s interpretation of Ex Parte Baurin is ineffective to overcome the rejection at least for the following reasons: (i). Ex Parte Baurin is not currently a precedential Board decision. (ii). An order by USPTO Director was entered on 03/05/2026 in the Baurin application (USSN 17135529, Appeal 2024-002920) convening an Appeals Review Panel to reconsider the PTAB decision reversing an examiner’s double patenting rejection. (iii). In Ex parte Baumeister (USSN 17409019, Appeal 2026 000193), PTAB reaffirmed that ODP rejections may rely on commonly owned patents even when those patents have later effective filing dates and later expiration dates. Accordingly, the grounds of rejection presented in section 8 of the previous office action are maintained, and are incorporated by reference herein as if reiterated in full. 5. Claims 57-64 stand provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over the claims of the copending applications USSN 18/049609, 18/444124, 17/611073 and USSN 18/930913 (all of record) for the reasons of record. Applicant has not substantively addressed the grounds of rejection presented in section 9 of the previous office action, which are therefore maintained and incorporated by reference herein as if reiterated in full. This is a provisional nonstatutory double patenting rejection because the patentably indistinct claims have not in fact been patented. 6. Conclusion: no claim is allowed. 7. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. 8. Any inquiry concerning this communication or earlier communications from the examiner should be directed to ILIA I OUSPENSKI whose telephone number is (571)272-2920. The examiner can normally be reached 9 AM - 5:30 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Julie Wu can be reached at 571-272-5205. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ILIA I OUSPENSKI/ Primary Examiner, Art Unit 1644
Read full office action

Prosecution Timeline

May 15, 2023
Application Filed
Jan 06, 2026
Non-Final Rejection mailed — §DP
Jul 02, 2026
Response Filed
Jul 14, 2026
Final Rejection mailed — §DP (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12703728
INTERLEUKIN 29 MUTANT PROTEIN
3y 8m to grant Granted Aug 11, 2026
Patent 12698512
METHODS COMPRISING ONCOLYTIC VIRUSES EXPRESSING CD19T AND BISPECIFIC T CELL ENGAGERS
1y 9m to grant Granted Aug 04, 2026
Patent 12692316
ANTIBODIES TO CANINE INTERLEUKIN-4 RECEPTOR ALPHA
4y 1m to grant Granted Jul 28, 2026
Patent 12686712
ANTIBODY, RELATED USE, PHARMACEUTICAL COMPOSITION INCLUDING METHOD FOR DIAGNOSING FUNGAL INFECTIONS, FUNGAL INFECTION DIAGNOSIS KIT AND METHOD FOR TREATING FUNGAL INFECTIONS
3y 11m to grant Granted Jul 21, 2026
Patent 12686718
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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
78%
Grant Probability
98%
With Interview (+20.4%)
2y 8m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1120 resolved cases by this examiner. Grant probability derived from career allowance rate.

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