Prosecution Insights
Last updated: July 17, 2026
Application No. 18/334,608

RIP1 Inhibitory Compounds and Methods for Making and Using the Same

Final Rejection §102
Filed
Jun 14, 2023
Priority
Sep 06, 2019 — provisional 62/897,223 +6 more
Examiner
MCDOWELL, BRIAN E
Art Unit
1624
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Rigel Pharmaceuticals Inc.
OA Round
4 (Final)
74%
Grant Probability
Favorable
5-6
OA Rounds
0m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 74% — above average
74%
Career Allowance Rate
833 granted / 1122 resolved
+14.2% vs TC avg
Strong +30% interview lift
Without
With
+30.4%
Interview Lift
resolved cases with interview
Typical timeline
2y 2m
Avg Prosecution
59 currently pending
Career history
1176
Total Applications
across all art units

Statute-Specific Performance

§101
0.3%
-39.7% vs TC avg
§103
23.4%
-16.6% vs TC avg
§102
19.3%
-20.7% vs TC avg
§112
51.0%
+11.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1122 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Status of Claims Claims 23, 24, 26-28, and 30-36 are pending in the instant application. Claims 26-28 and 30-36 are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being drawn to a nonelected invention, there being no allowable generic or linking claim. An action on the merits of claims 23-24 is contained herein. Status of Rejections 35 USC § 102 The rejection of claims 23-24 is maintained. Applicant’s arguments, see Remarks, filed 4/14/2026, with respect to the rejection set forth in the Non-Final Office Action mailed 10/16/2025, have been fully considered but are not found persuasive. To reiterate the rejection of record; claims 23-24 are rejected under 35 U.S.C. 102(a)(2) as being anticipated over Chen et al. (WO 2021/046407-previously mentioned of record). Chen et al. teach the following compound and compositions thereof which anticipate the claims (see page 216, compound I-178 of related provisional application 62/897223 and page 95 for compositions thereof): PNG media_image1.png 188 722 media_image1.png Greyscale which corresponds to compound I-I in the instant claims. Thus the claims are anticipated. Applicant has argued that both Chen and the instant application claim priority to the same provisional application 62/897223 and thus Chen does not qualify as prior art. The examiner respectfully disagrees. Applicants are reminded of the following regarding priority of the instant claims (see office action 11/5/2024): This application claims the benefit of earlier filed U.S. Provisional Application Nos. 62/897,223, filed on September 6, 2019; 62/932,404, filed on November 7, 2019; 63/001,016,filed on March 27, 2020; 63/004,290, filed on April 2, 2020; 63/004,319, filed April 2, 2020,and 63/004,301, filed on April 2, 2020. Benefit for provisional applications 62/897,223 and 62/932,404 is not accorded since subject matter disclosed within the instant application is not supported (e.g. the elected species and compounds embracing a benzoazepine core). The claims in a U.S. application are entitled to the benefit of a foreign priority date or the filing date of a provisional application if the corresponding foreign application or provisional application supports the claims in the manner required by 35 U.S.C. 112(a) or pre-AIA 35 U.S.C. 112, first paragraph. In re Ziegler, 992 F.2d 1197, 1200, 26 USPQ2d 1600, 1603 (Fed. Cir. 1993); Kawaiv.Metlesics, 480 F.2d 880, 178 USPQ 158 (CCPA 1973); In re Gosteli, 872 F.2d 1008, 10 USPQ2d 1614 (Fed. Cir. 1989). Note again that the claims have the earliest priority date of 3/27/2020 since all of the claimed species embracing a benzoazepine core are not supported in the provisional applications. Thus, Chen is still applicable as prior art the rejection is maintained. Conclusion No claims are allowed. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to BRIAN E MCDOWELL whose telephone number is (571)270-5755. The examiner can normally be reached on 8:30-6 MF. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Jeffrey Murray can be reached at 571-272-9023. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRIAN E MCDOWELL/Primary Examiner, Art Unit 1624
Read full office action

Prosecution Timeline

Show 2 earlier events
Jan 16, 2025
Response Filed
Mar 28, 2025
Final Rejection mailed — §102
Jun 24, 2025
Response after Non-Final Action
Jul 21, 2025
Request for Continued Examination
Jul 22, 2025
Response after Non-Final Action
Oct 16, 2025
Non-Final Rejection mailed — §102
Apr 14, 2026
Response Filed
May 18, 2026
Final Rejection mailed — §102 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

5-6
Expected OA Rounds
74%
Grant Probability
99%
With Interview (+30.4%)
2y 2m (~0m remaining)
Median Time to Grant
High
PTA Risk
Based on 1122 resolved cases by this examiner. Grant probability derived from career allowance rate.

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