Prosecution Insights
Last updated: April 19, 2026
Application No. 18/340,054

USE OF FUBP1 INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

Non-Final OA §102
Filed
Jun 23, 2023
Examiner
SEAMAN, D MARGARET M
Art Unit
1625
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
INSERM
OA Round
3 (Non-Final)
77%
Grant Probability
Favorable
3-4
OA Rounds
2y 4m
To Grant
84%
With Interview

Examiner Intelligence

Grants 77% — above average
77%
Career Allow Rate
1063 granted / 1387 resolved
+16.6% vs TC avg
Moderate +8% lift
Without
With
+7.9%
Interview Lift
resolved cases with interview
Typical timeline
2y 4m
Avg Prosecution
20 currently pending
Career history
1407
Total Applications
across all art units

Statute-Specific Performance

§101
3.7%
-36.3% vs TC avg
§103
15.1%
-24.9% vs TC avg
§102
24.3%
-15.7% vs TC avg
§112
33.9%
-6.1% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1387 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . RCE papers were filed 01/22/2026. Election/Restrictions Claims 1-4 and 6-20 remain withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Election was made without traverse in the reply filed on 04/18/2025. Applicant is reminded that upon the cancelation of claims to a non-elected invention, the inventorship must be corrected in compliance with 37 CFR 1.48(a) if one or more of the currently named inventors is no longer an inventor of at least one claim remaining in the application. A request to correct inventorship under 37 CFR 1.48(a) must be accompanied by an application data sheet in accordance with 37 CFR 1.76 that identifies each inventor by his or her legal name and by the processing fee required under 37 CFR 1.17(i). Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim 5 remains rejected under 35 U.S.C. 102(a)(1) as being anticipated by WO2018013929. WO teaches compound VIII (GSK343) on page 15 and that the compounds of the invention have the ability to treat T cell exhaustion which includes treating chronic viral disease (e.g. HBV) (page 4 line 30). The WO teaches that the compound GSK343 which is compound VIII of the instant claim 5 treats HBV. The same patient population with the same condition being treated with the same drug with the same outcome means that the same drug (GSK343 which is the instant compound VIII) means that GSK343 must be treating HBV infection by reducing cccDNA and/or pgRNA in infected cells. This in inherency. This anticipates the instant claim 5. Conclusion Claim 5 is rejected. Claims 1-4 and 6-20 remain withdrawn. No claim is allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to D MARGARET M SEAMAN whose telephone number is (571)272-0694. The examiner can normally be reached M-F 8am-4pm Eastern. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Andrew Kosar can be reached at 571-272-0913. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /D MARGARET M SEAMAN/Primary Examiner, Art Unit 1625
Read full office action

Prosecution Timeline

Jun 23, 2023
Application Filed
May 13, 2025
Non-Final Rejection — §102
Sep 03, 2025
Response Filed
Sep 18, 2025
Final Rejection — §102
Dec 23, 2025
Response after Non-Final Action
Jan 22, 2026
Request for Continued Examination
Jan 28, 2026
Response after Non-Final Action
Jan 29, 2026
Non-Final Rejection — §102 (current)

Precedent Cases

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Patent 12590072
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Patent 12577207
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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
77%
Grant Probability
84%
With Interview (+7.9%)
2y 4m
Median Time to Grant
High
PTA Risk
Based on 1387 resolved cases by this examiner. Grant probability derived from career allow rate.

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