Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
DETAILED ACTION
Status of the Claims
Claims 1, 6, 10-11, and 13-15 are pending and are examined on their merits.
Claim Objections
Claims 10 and 11 are objected to under 37 CFR 1.75(c) as being in improper form because a multiple dependent claim must be in the alternative (OR) form and not the inclusive (AND) form. See MPEP § 608.01(n).
Additionally, claims 10 and 11 each are dependent on claims 2 and 5, which have been canceled.
Claim Rejections - 35 USC § 112(d)
The following is a quotation of 35 U.S.C. 112(d):
(d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers.
The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph:
Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers.
Claims 10 and 11 rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends.
Claims 10 and 11 are rejected as being in improper form because a multiple dependent claim must be in the alternative (OR) form and not the inclusive (AND) form.
Additionally, claims 10 and 11 each are dependent on claims 2 and 5, which have been canceled.
Applicant may cancel the claims, amend the claims to place the claims in proper dependent form, rewrite the claims in independent form, or present a sufficient showing that the dependent claims comply with the statutory requirements.
Allowable Subject Matter
Claims 1, 6, 10-11, and 13-15 are free of the prior art.
Claims 1, 6, and 13-15 are allowed.
Applicant has developed compounds of Formula (I):
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157
235
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Said compounds act as inhibitors of CD73, a protein commonly overexpressed in cancer cells. Applicant’s compounds are free of the art.
The closest compounds in the art are each developed by applicant.
The compounds of U.S. Patent No. 12,110,294 differ from the instant compounds in the nitrogenous ring attached to the pyrimidine-2,4-dione:
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305
285
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The compounds of all of U.S. Patent No. 11,919,869, co-pending Application No. 19/075,160, and co-pending Application No. 17/997,594 and differ from the instant compounds in a similar manner:
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178
250
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148
202
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145
204
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As the modifications needed to get from any of these compounds to applicant’s compounds would not be obvious to one of ordinary skill in the art, claims 1, 6, 10-11, and 13-15 are free of the prior art.
Conclusion
Any inquiry concerning this communication or earlier communications from the examiner should be directed to Anthony Seitz whose telephone number is (703)756-4657. The examiner can normally be reached 7:30 AM ET - 5:00 PM ET M-F.
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/ANTHONY JOSEPH SEITZ/Examiner, Art Unit 1629
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