DETAILED ACTION
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
Status of the Claims
The Amendment filed January 20, 2026 has been entered. Claims 1, 4, and 6 have been amended; claims 10-21 are new; and claims 8-9 have been cancelled. Claims 1-7 and 10-21 are currently pending and examined herein.
Status of the Rejection
Applicant’s amendments to the Claims have overcome each objection previously set forth in the Non-Final Office Action mailed October 22, 2025.
New grounds of claim objection are necessitated by the amendment as outlined below.
New grounds of claim rejections under 35 U.S.C. § 112(a) are necessitated by the amendment as outlined below.
All 35 U.S.C. § 102 and 103 rejections from the previous office action are withdrawn in view of the Applicant’s amendment.
All double patenting rejections from the previous office action are withdrawn in view of the Applicant’s amendment.
New grounds of rejection under 35 U.S.C. § 103 are necessitated by the amendments as outlined below.
New grounds of double patenting objection are necessitated by the amendments as outlined below.
Information Disclosure Statement
The information disclosure statement (IDS) submitted on 12/18/2025 has been considered by the examiner.
Claim Objection
Claims 10-13 are objected to because of the following informalities:
Claim 10: please amend “diallylamine-acrylamide polymer” to –the diallylamine-acrylamide polymer--.
Claim 11: please amend “dimethylamine-ammonia-epichlorohydrin polymer” to –the dimethylamine-ammonia-epichlorohydrin polymer--.
Claim 12: please amend “allylamine-diallylamine polymer” to –the allylamine-diallylamine polymer--.
Claim 13: please amend “diallyldimethylammonium chloride polymer” to –the diallyldimethylammonium chloride polymer--.
Appropriate correction is required.
Claim Rejections - 35 USC § 112
The following is a quotation of the first paragraph of 35 U.S.C. 112(a):
(a) IN GENERAL.—The specification shall contain a written description of the invention, and of the manner and process of making and using it, in such full, clear, concise, and exact terms as to enable any person skilled in the art to which it pertains, or with which it is most nearly connected, to make and use the same, and shall set forth the best mode contemplated by the inventor or joint inventor of carrying out the invention.
The following is a quotation of the first paragraph of pre-AIA 35 U.S.C. 112:
The specification shall contain a written description of the invention, and of the manner and process of making and using it, in such full, clear, concise, and exact terms as to enable any person skilled in the art to which it pertains, or with which it is most nearly connected, to make and use the same, and shall set forth the best mode contemplated by the inventor of carrying out his invention.
Claim 4 is rejected under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, as failing to comply with the written description requirement. The claim(s) contains subject matter which was not described in the specification in such a way as to reasonably convey to one skilled in the relevant art that the inventor or a joint inventor, or for applications subject to pre-AIA 35 U.S.C. 112, the inventor(s), at the time the application was filed, had possession of the claimed invention.
Claim 4 recites “wherein the cationic polymer “further” comprises at least one selected from the group consisting of dimethylamine-epichlorohydrin polymer, polyethyleneimine, polyallylamine, polydiallylamine, and polymethyldiallylamine. The amended claim 1 recites the cationic polymer comprises at least one selected from the group consisting of diallylamine-acrylamide polymer, dimethylamine-ammonia-epichlorohydrin polymer, allylaminediallylamine polymer, and diallyldimethylammonium chloride polymer. Thus, in claim 4 the cationic polymer comprises at least one polymer selected from the group consisting of diallylamine-acrylamide polymer, dimethylamine-ammonia-epichlorohydrin polymer, allylaminediallylamine polymer, and diallyldimethylammonium chloride polymer, and at least another polymer selected from the group consisting of dimethylamine-epichlorohydrin polymer, polyethyleneimine, polyallylamine, polydiallylamine, and polymethyldiallylamine, which is not supported in the specification. The instant specification discloses “The specific alkaline solution may contain two or more cationic polymers” [para. 0072 in PGPub], and [para.0077-0079, 0083 in PGPub ] discloses the cationic polymer. However, the specification does not disclose that the specific combinations of the cationic polymer, which comprises at least one selected from the group of claim 1 and at least another one selected from the group of claim 4. Therefore, claim 4 is a new matter.
Claim Rejections - 35 USC § 103
The text of those sections of Title 35, U.S. Code not included in this action can be found in a prior Office action.
Claims 1-5, 7, and 10-21 are rejected under 35 U.S.C. 103 as being unpatentable over Onuma et al. (JP2016136135A, English translation, hereinafter Onuma’135), and in view of Onuma (US20200011850A1). Onuma’135 is provided in IDS filed on 10/24/2023.
Regarding claim 1, Onuma’135 teaches a sample analysis method (a method for analyzing a sample by capillary electrophoresis [abstract; Fig. 1]), comprising:
separating hemoglobin from a sample comprising the hemoglobin (separating hemoglobin in a sample by capillary electrophoresis [abstract]; the separation of hemoglobin includes separating at least one of HbS and HbA2, and preferably includes separating HbS and HbA2 [para. 0025]), in an alkaline solution by capillary electrophoresis (separating the hemoglobin in alkaline solution containing cationic polymer [abstract]),
wherein the alkaline solution comprises a cationic polymer (separating the hemoglobin in alkaline solution containing cationic polymer [abstract, para. 0033]; [para. 0016-0017] details the cationic polymer), and
the cationic polymer comprises at least one selected from the group consisting of diallylamine-acrylamide polymer (polyquaternium-7 which is copolymer of acrylamide and diallyldimethylammonium chloride [para. 0017]), dimethylamine-ammonia-epichlorohydrin polymer (cationic polymer having a quaternary ammonium base or a
group that can be ionized to a quaternary ammonium base includes dimethylamine-epichlorohydrin copolymer [para. 0017]), and diallyldimethylammonium chloride polymer (polyquaternium-6 which is poly(diallyldimethylammonium chloride) [para. 0017]).
Onuma’135 teaches separating hemoglobin from the sample containing the hemoglobin in the alkaline solution comprising the cationic polymer by capillary electrophoresis, thus is silent to separating albumin and γ-globulin from a sample comprising the albumin and the γ-globulin.
Onuma teaches a sample analysis method (a sample analysis method by capillary electrophoresis [abstract; Figs. 4-5]) for separating components contained in blood including hemoglobin (Hb), albumin (A1b), globulin (α1, α2, β, and γ globulins), and fibrinogen [para. 0046], in an alkaline solution by capillary electrophoresis (in the separation process [S5], a voltage may be applied after the anode is brought into contact with the second liquid stored in the sample reservoir 1, and the cathode is brought into contact with the first liquid stored in the electrophoresis liquid reservoir 3. It is preferable to use an alkaline solution containing a cationic polymer for the first liquid and the second liquid [para. 0068]). Onuma further teaches a cationic polymer described in Japanese Patent No. 6052927 may be used [para. 0064]. Onuma’135 is the Japanese Patent No. 6052927. Thus, Onuma teaches an analysis method for separating components including hemoglobin (Hb), albumin (A1b), globulin (α1, α2, β, and γ globulins), and fibrinogen contained in the blood, in an alkaline solution comprising a cationic polymer by capillary electrophoresis, and the cationic polymer is the same as that of Onuma’135. Therefore, the sample analysis methods in both Onuma’135 and Onuma are essentially the same, but are used to separate different components in the sample.
It would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to take sample analysis method of Onuma’135 to separate components including hemoglobin (Hb), albumin (A1b), globulin (α1, α2, β, and γ globulins), and fibrinogen contained in blood, as taught by Onuma, since Onuma teaches the same sample analysis method for separating and analyzing components including hemoglobin (Hb), albumin (A1b), globulin (α1, α2, β, and γ globulins), and fibrinogen contain in blood [para. 0046].
Since the disclosed sample analysis method can be used to separate a sample containing components including hemoglobin (Hb), albumin (A1b), globulin (α1, α2, β, and γ globulins), and fibrinogen [para. 0046 in Onuma], it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to take the sample analysis method that can separate components including hemoglobin (Hb), albumin (A1b), globulin (α1, α2, β, and γ globulins), and fibrinogen to separate a sample containing albumin and γ globulin. Choosing from a finite number of identified, predictable solutions, with a reasonable expectation for success, is likely to be obvious to a person of ordinary skill in the art. See MPEP § 2143(E).
Regarding claim 2, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein a weight average molecular weight of the cationic polymer is from 10,000 to 500,000 (the weight-average molecular weight of the cationic polymer is 10,000 or more from the viewpoint of improving the accuracy of analysis, and 500,000 or less from the viewpoint of preventing an increase in solution viscosity [para. 0018]).
Regarding claim 3, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein a weight average molecular weight of the cationic polymer is from 10,000 to 500,000 (the weight-average molecular weight of the cationic polymer is 10,000 or more from the viewpoint of improving the accuracy of analysis, and 500,000 or less from the viewpoint of preventing an increase in solution viscosity [para. 0018]).
Onuma’135 is silent to wherein a weight average molecular weight of the cationic polymer is from 15,000 to 150,000, but the disclosed molecular weight range of 10,000 to 500,000 overlaps with the claimed range.
It would have been obvious to have selected and utilized a cationic polymer with a weight average molecular weight within the disclosed range, as taught by Onuma’135, including those amounts that overlap within the claimed range, since one of ordinary skill in the art would reasonably expect any value within the taught range to be suitable given that Onuma’135 specifically teaches the range to be suitable for the cationic polymer from the viewpoint of improving the accuracy of analysis and preventing an increase in solution viscosity [para. 0018]. It has been held that obviousness exists where the claimed ranges overlap or lie inside ranges disclosed by the prior art. See MPEP 2144.05 (I).
Regarding claim 4, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 does not explicitly teach wherein the cationic polymer “further” comprises at least one selected from the group consisting of dimethylamine-epichlorohydrin polymer, polyethyleneimine, polyallylamine, polydiallylamine, and polymethyldiallylamine.
Onuma’135 does teach the cationic polymer can be used alone or in combination of two or more kinds [para. 0016]. Onuma’135 further teaches other examples of the cationic polymers include dimethylamine-epichlorohydrin polymer (dimethylamine-epichlorohydrin copolymer [para. 0017]), polyethyleneimine (examples of the cationic polymer having an imino group or a group that can be ionized to an imino group include polyethyleneimine [para. 0017]), polyallylamine (polyallylamine [para. 0017]), polydiallylamine (polydiallylamine [para. 0017]), and polymethyldiallylamine (polymethyldiallylamine [para. 0017]).
It would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to combine two or more kinds of cationic polymers such that the cationic polymer further comprises at least one selected from the group consisting of dimethylamine-epichlorohydrin polymer, polyethyleneimine, polyallylamine, polydiallylamine, and polymethyldiallylamine, as taught by Onuma’135, since Onuma’135 teaches the cationic polymer can be used in combination of two or more kinds. Furthermore, choosing from a finite number of identified alternative cationic polymers to be combined, predictable solutions, with a reasonable expectation for success, is likely to be obvious to a person of ordinary skill in the art. See MPEP § 2143(E).
Regarding claim 5, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein a content ratio of the cationic polymer with respect to a total mass of the alkaline solution is from 0.01 mass % to 10 mass % (the content of the cationic polymer in the alkaline solution is 0.01% (W/V) or more, 0.05% (W/V) or more, or 0.1% (W/V) or more from the viewpoint of improving the accuracy of analysis, and 10.0% (W/V) or less, 8.0% (W/V) or less, or 5.0% (W/V) or less from the viewpoint of preventing an increase in solution viscosity [para. 0021]).
Regarding claim 7, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein a pH of the alkaline solution is from 8.5 to 12.0 (the pH of the alkaline solution is preferably 8.5 or higher, or 9.5 or higher and it is preferably 12.0 or lower, or 11.0 or lower [para. 0020]).
Regarding claim 10, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein the cationic polymer comprises the diallylamine-acrylamide polymer (polyquaternium-7 which is copolymer of acrylamide and diallyldimethylammonium chloride [para. 0017]).
Regarding claim 11, modified Onuma’135 teaches the sample analysis method according to claim 1, wherein the cationic polymer comprises the dimethylamine-ammonia-epichlorohydrin polymer (cationic polymer having a quaternary ammonium base or a group that can be ionized to a quaternary ammonium base includes dimethylamine-epichlorohydrin copolymer [para. 0017]).
Regarding claim 12, modified Onuma’135 teaches the sample analysis method according to claim 1, and is silent to wherein the cationic polymer comprises allylamine-diallylamine polymer.
Onuma’135 does teach wherein examples of cationic polymers having primary to tertiary amino groups or groups that can be ionized to primary to tertiary amino groups include polyallylamine, polyvinylamine, polylysine, polyarginine, polyhistidine, polyornithine, polydiallylamine, and polymethyldiallylamine [para. 0017]. The cationic polymers can be used alone or in combination of two or more kinds [para. 0016].
Since Onuma’135 teaches that the polymer of allylamine and the polymer of diallyalamine are both suitable as the cationic polymer, and the cationic polymers can be used alone or in combination of two or more kinds, the skilled artisan would have been motivated to use the mixture of allylamine and diallyamine to form allylamine-diallylamine polymer since it is prima facie obvious to combine two compositions each of which is taught by the prior art to be useful for the same purpose, in order to form a third composition to be used for the very same purpose. Furthermore, the formed allylamine-diallylamine polymer is also a cationic polymer carrying a positive charge, and would perform the functions of the cationic polymers of the allylamine and the diallyamine.
Regarding claim 13, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein the cationic polymer comprises diallyldimethylammonium chloride polymer (polyquaternium-6 which is poly(diallyldimethylammonium chloride) [para. 0017]).
Regarding claim 14, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein the separating is performed in an electrophoresis chip (capillary electrophoresis chip in Fig.1 [para. 0013, 0046]) comprising a sample holding tank (sample reservoir 11 in Fig.1A [para. 0046]), an electrophoretic liquid holding tank (an electrophoresis buffer reservoir 12 in Fig.1A [para. 0046]), and a capillary flow path (capillary channel 10 in Fig.1A [para. 0046]), wherein the sample holding tank and the electrophoretic liquid holding tank are communicated with each other via the capillary flow path (see Fig.1A).
Regarding claim 15, modified Onuma’135 teaches the sample analysis method according to claim 14, and Onuma’135 teaches wherein a cross section of the capillary flow path is rectangular or circular (the cross-sectional shape of the capillary channel is not particularly limited and may be circular or rectangular [para. 0027]).
Regarding claim 16, modified Onuma’135 teaches the sample analysis method according to claim 14, and Onuma’135 teaches wherein a cross section of the capillary flow path is rectangular (the cross-sectional shape of the capillary channel is not particularly limited and may be circular or rectangular [para. 0027]).
Onuma’135 is silent to wherein the rectangular capillary flow path having a width and a height in a range of 1 µm to 1000 µm.
Onuma teaches capillary flow path having depth 0.04 mm×width 0.04 mm×length 30 mm [para. 0102]. Thus, Onuma teaches wherein the rectangular capillary flow path having a width and a height in a range of 1 µm to 1000 µm (depth 0.04 mm×width 0.04 mm; 0.04 mm is 40 µm).
It would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify the capillary flow path of modified Onuma’135 to a rectangular capillary flow path having a width of 40 µm and a height of 40 µm, as taught by Onuma, since Onuma teaches the dimensions of the width and the height of the capillary flow path suitable for sample analysis by capillary electrophoresis [para. 0102].
Regarding claim 17, modified Onuma’135 teaches the sample analysis method according to claim 14, and Onuma’135 teaches wherein a cross section of the capillary flow path is circular (capillary channel is a tube having an inner diameter of 100 µm or less [para. 0027]), a radius of which is in a range of 10 µm to 100 µm (the inner diameter of the capillary channel is 25 μm or more, and 100 μm or less [para. 0027]; thus the radius is in a range of 12.5 μm to 50 μm, falling within the claimed radius range).
Regarding claim 18, modified Onuma’135 teaches the sample analysis method according to claim 14, and Onuma’135 teaches wherein a length of the capillary flow path is in a range of 20 mm to 150 mm (the length of the capillary channel is 20 mm or more and 150 mm or less [para. 0027]).
Onuma’135 is silent to wherein the length of the capillary channel is in a range of 100 mm to 150 mm, but the disclose range of the length overlaps with the claimed length range.
It would have been obvious to have selected and utilized a capillary channel with a length within the disclosed length range, as taught by Onuma’135, including those amounts that overlap within the claimed range, since one of ordinary skill in the art would reasonably expect any value within the taught range to be suitable given that Onuma’135 specifically teaches the range to be suitable for the length of the capillary channel [para. 0027]. It has been held that obviousness exists where the claimed ranges overlap or lie inside ranges disclosed by the prior art. See MPEP 2144.05 (I).
Regarding claim 19, modified Onuma’135 teaches the sample analysis method according to claim 14, wherein the separating includes applying an electric voltage in a range of 500 V to 10000 V to the electrophoresis chip (Onuma’135 teaches the applied voltage is 1500 V [para. 0064]; Onuma also teaches the applied voltage is about 1500 V [para. 0114]).
Regarding claim 20, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein the cationic polymer is a polymer having a quaternary ammonium base (the cationic group may be a polymer having a quaternary ammonium base [para. 0016]; the cationic polymer having a quaternary ammonium base or a group that can be ionized to a quaternary ammonium base includes polyquaternium, dimethylamine-epichlorohydrin copolymer [para. 0017]).
Regarding claim 21, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma’135 teaches wherein the alkaline solution has a pH in a range of 8.5 to 12.0 (the pH of the alkaline solution is preferably 8.5 or higher, or 9.5 or higher and it is preferably 12.0 or lower, or 11.0 or lower [para. 0020]).
Claim 6 is rejected under 35 U.S.C. 103 as being unpatentable over Onuma’135 and Onuma, as applied to claim 1 above, and further in view of Shigemitsu et al. (JP2018072330A, English translation).
Regarding claim 6, modified Onuma’135 teaches the sample analysis method according to claim 1, and Onuma teaches wherein an electrophoresis time of the capillary electrophoresis in the separation is 35 sec [para. 0115].
Modified Onuma’135 is silent to wherein an electrophoresis time of the capillary electrophoresis in the separation is from 50 seconds to less than 250 seconds.
Shigemitsu teaches a sample analysis method for separating and analyzing components including hemoglobin (Hb), albumin (Alb), globulins (α1, α2, β, γ globulins), and fibrinogen contained in blood by a capillary electrophoresis [para. 0018-0019], wherein a cationic polymer is immobilized on inner walls of the sample section and the analysis section (claim 1), and examples of the cationic polymers include polyquaternium-6 (poly(diallyldimethylammonium chloride)) and polyquaternium-7 (copolymer of acrylamide and diallyldimethylammonium chloride) [para. 0043]. Shigemitsu further teaches electrophoresis was carried out for 60 seconds [para. 0087]. Note that polyquaternium-6 and polyquaternium-7 are, respectively, the diallyldimethylammonium chloride polymer and the diallylamine-acrylamide polymer of instant claim 1 above. Thus, Shigemitsu teaches a sample analysis method that can be used to separate albumin and γ globulin by capillary electrophoresis using the same cationic polymer and the electrophoresis time in the separation is 60 sec.
It would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention modify the electrophoresis time in modified Onuma’135 to 60 seconds, as taught by Shigemitsu, since Shigemitsu teaches a suitable alternative electrophoresis time of 60 seconds that can be used to separate albumin and γ globulin by capillary electrophoresis [para. 0018-0019, 0087].
Double Patenting Objection
A rejection based on double patenting of the “same invention” type finds its support in the language of 35 U.S.C. 101 which states that “whoever invents or discovers any new and useful process... may obtain a patent therefor...” (Emphasis added). Thus, the term “same invention,” in this context, means an invention drawn to identical subject matter. See Miller v. Eagle Mfg. Co., 151 U.S. 186 (1894); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Ockert, 245 F.2d 467, 114 USPQ 330 (CCPA 1957).
Applicant is advised that should claim 7 be found allowable, claim 21 will be objected to under 37 CFR 1.75 as being a substantial duplicate thereof. When two claims in an application are duplicates or else are so close in content that they both cover the same thing, despite a slight difference in wording, it is proper after allowing one claim to object to the other as being a substantial duplicate of the allowed claim. See MPEP § 608.01(m). In the instant case, the limitation of claim 21 is essentially the same as that recited in claim 7.
Response to Arguments
Applicant's arguments, see Remarks Pgs. 5-7, filed 1/20/2026, with respect to the 35 U.S.C. § 102(a)(1) and 35 U.S.C. § 103 rejections have been fully considered and all prior art rejections from the previous office action have been withdrawn in view of the amendment.
Applicant’s Argument #1:
Regarding claim 1, applicant argues at page 5 that Onuma's alkaline solution, however, does not include any of the specific cationic polymer listed in the amended claim 1.
Examiner’s Response #1:
Applicant’s arguments have been fully considered, but are moot in view of the new grounds of rejection for the amended claim 1 above.
Applicant’s Argument #2:
Regarding claims 2-7, Applicant argues at pages 5-6 that Onuma fails to disclose each and every limitation of the amended independent claim 1, on which claims 2-7 depend, and Onuma'359 fails to remedy the deficiencies in Onuma. Furthermore, Onuma'359 is directed to an analysis method for hemoglobin, which has physical properties significantly different from those of albumin or y-globulin recited in the present claims. Accordingly, from reading Onuma'359, one of ordinary skill in the art would have no reason to apply the methods for hemoglobin to reach the claimed method for albumin or y-globulin as set forth in the claims.
Examiner’s Response #2:
As outlined in the new grounds of rejection for the amended claim 1 above, the amended claim 1 is still unpatentable over the prior art. Note that Onuma'359 is not used in the new grounds of rejection for claims 2-7 in view of the amendment to claim 1.
Applicant’s Argument #3:
Regarding double patenting, applicant argues at page 6 that none of the claims of the copending Application No. 18/383,317 recite the amended feature: "the cationic polymer comprises at least one selected from the group consisting of diallylamine-acrylamide polymer, dimethylamine-ammonia-epichlorohydrin polymer, allylamine-diallylamine polymer, and diallyldimethylammonium chloride polymer."
Examiner’s Response #3:
Applicant’s arguments are convincing and all double patenting rejections from the previous office actions have been withdrawn.
Conclusion
Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a).
A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action.
Any inquiry concerning this communication or earlier communications from the examiner should be directed to SHIZHI QIAN whose telephone number is (571)272-3487. The examiner can normally be reached Monday-Thursday 8:00 am-5:00 pm.
If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Luan V Van can be reached on 571-272-8521. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300.
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/SHIZHI QIAN/Examiner, Art Unit 1795