Prosecution Insights
Last updated: August 01, 2026
Application No. 18/385,444

APPLICATION OF 10'(Z), 13'(E), 15'(E)-HEPTADECATRIENYL HYDROQUINONE (HQ17(3)) IN TREATING CORONAVIRUS INFECTION

Final Rejection §112
Filed
Oct 31, 2023
Priority
Aug 15, 2023 — TW 112130678
Examiner
VALLE, ERNESTO
Art Unit
1623
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
National Atomic Research Institute
OA Round
2 (Final)
61%
Grant Probability
Moderate
3-4
OA Rounds
7m
Est. Remaining
97%
With Interview

Examiner Intelligence

Grants 61% of resolved cases
61%
Career Allowance Rate
14 granted / 23 resolved
+0.9% vs TC avg
Strong +36% interview lift
Without
With
+35.7%
Interview Lift
resolved cases with interview
Typical timeline
3y 4m
Avg Prosecution
44 currently pending
Career history
79
Total Applications
across all art units

Statute-Specific Performance

§103
56.6%
+16.6% vs TC avg
§102
12.2%
-27.8% vs TC avg
§112
10.2%
-29.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 23 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Priority Acknowledgment is made of applicant's claim for foreign priority under 35 U.S.C. 119 (a)-(d). The certified copy has been filed in parent Application No. TAIWAN 112130678, filed on 08/15/2023. Information Disclosure Statement The information disclosure statement (IDS) submitted on 10/31/2023 was filed in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statements are being considered by the examiner. Status of claims Claims 1, and 3-11 are pending in this application and are currently under examination. Claims 1, 3, and 9 have been amended. Claim 2 has been cancelled by applicant without prejudice or disclaimer. Applicant’s arguments, filed 02/20/2026, have been fully considered. Rejections and/or objections not reiterated from previous office actions are hereby withdrawn. They constitute the complete set presently being applied to the instant application. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. Claim 6 is rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. Dependent claim 6 cites the limitation wherein the disease caused by the coronavirus infection is a respiratory disease caused by SARS-CoV or SARS-CoV-2, which is broader than the scope of limitations from independent claim 1 which does not encompass any respiratory disease caused by SARS-CoV or SARS-CoV2. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. This rejection may be overcome by amending the language of claim 6 to say “wherein the disease caused by the coronavirus infection is severe respiratory syndrome coronavirus SARS-CoV, Middle East Respiratory Syndrome coronavirus (MERS-CoV)”, or other intended respiratory conditions applicant is enabled by specification to encompass. Allowable Subject Matter The following is a statement of reasons for the indication of allowable subject matter: Applicants method of treating a coronavirus infection by administering the compound of formula 12 makes a contribution over the prior art of record of Furman (WO 2023/027951 Al). Furman discloses the compound of l0l(Z), 13 '(E), 15'(E) Heptadecatrienyl hydroquinone (pg. 170) which does satisfy the structural limitations of applicant’s compound of formula 12 but does not fairly teach or suggest it’s explicit use in a method of treatment of a coronavirus infection or disease in a subject in need thereof, more specifically, HCoV-229E alpha coronavirus, HCoV-NL63 alpha coronavirus, HCoV-HKUl beta coronavirus, HCoV-OC43 beta coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome coronavirus (MERS-CoV) or the novel coronavirus (SARS-CoV-2). Therefore the instant claims of 1, 4-5, and 7-11 are found allowable as of the current record. Conclusion Claims 1, 3-5, and 7-11 are allowable, claim 6 is rejected. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to ERNESTO VALLE JR whose telephone number is (703)756-5356. The examiner can normally be reached 0730-1700 M-F EST, 1st Friday off. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Adam C Milligan can be reached at 571-270-7674. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /E.V./Examiner, Art Unit 1623 /SAMANTHA L SHTERENGARTS/Primary Examiner, Art Unit 1623
Read full office action

Prosecution Timeline

Oct 31, 2023
Application Filed
Nov 24, 2025
Non-Final Rejection mailed — §112
Feb 20, 2026
Response Filed
Apr 29, 2026
Final Rejection mailed — §112
Jul 29, 2026
Request for Continued Examination
Jul 31, 2026
Response after Non-Final Action

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12673914
CONTINUOUS PROCESS FOR THE SYNTHESIS OF DIMETHYL CARBONATE OVER A CERIUM-BASED CATALYST FORMULATION
2y 11m to grant Granted Jul 07, 2026
Patent 12662460
COMPOSITIONS FOR USE FOR THE INHIBITION OF DIHYDROOROTATE DEHYDROGENASE
3y 12m to grant Granted Jun 23, 2026
Patent 12589092
POLYCYCLIC COMPOUND ACTING AS KINASE INHIBITOR
3y 9m to grant Granted Mar 31, 2026
Patent 12582628
METHODS FOR TREATING BREAST CANCER
3y 11m to grant Granted Mar 24, 2026
Patent 12564569
CARBOPLATIN COMPLEX AND PHARMACEUTICAL PREPARATION THEREOF
4y 0m to grant Granted Mar 03, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.
Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

3-4
Expected OA Rounds
61%
Grant Probability
97%
With Interview (+35.7%)
3y 4m (~7m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 23 resolved cases by this examiner. Grant probability derived from career allowance rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month