Prosecution Insights
Last updated: April 19, 2026
Application No. 18/386,643

PURIFICATION METHOD FOR SUCRALOSE-6-ETHYL ESTER

Non-Final OA §112
Filed
Nov 03, 2023
Examiner
MCINTOSH III, TRAVISS C
Art Unit
1693
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Anhui Jinhe Industrial Co. Ltd.
OA Round
1 (Non-Final)
73%
Grant Probability
Favorable
1-2
OA Rounds
2y 7m
To Grant
87%
With Interview

Examiner Intelligence

Grants 73% — above average
73%
Career Allow Rate
960 granted / 1312 resolved
+13.2% vs TC avg
Moderate +14% lift
Without
With
+13.9%
Interview Lift
resolved cases with interview
Typical timeline
2y 7m
Avg Prosecution
28 currently pending
Career history
1340
Total Applications
across all art units

Statute-Specific Performance

§101
3.5%
-36.5% vs TC avg
§103
14.8%
-25.2% vs TC avg
§102
24.3%
-15.7% vs TC avg
§112
31.3%
-8.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1312 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Specification The disclosure is objected to because of the following informalities: In Tables 1-8, applicants showed a comparison with a single boiling process and differing embodiments of multiple boiling steps as in embodiments 1-8 herein. However, the tables all read as having a “white oil untreated” group and “Embodiment 1”. These tables should have the “white oil untreated” group and “Embodiment 1” for table 1; “Embodiment 2” for table 2; “Embodiment 3” for Table 3, etc. Appropriate correction is required. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-10 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. The claims as drafted are a bit confusing and clarity is respectfully requested. Claim 1 provides “A purification method for sucralose-6-ethyl ester, with white oil used as an extractant in the chlorination section of the sucralose-6-ethyl ester preparation process, wherein the method comprises”. It is confusing as there is no recitation of a prior chlorination section, for example. The claim would be better read as: “A purification method for sucralose-6-ethyl ester, where white oil was used as an extractant in the chlorination section of the sucralose-6-ethyl ester preparation process, wherein the method comprises”. Likewise, the claim is confusing in the portions reading: “a secondary water boiling step: taking..”; “a phase separating extraction step: standing…”; “a recrystallizing purification step: evaporating…”; and “and a recycling step: separating…” wherein the claims would be better written as: “performing a secondary water boiling step: comprising taking”; “performing a phase separating extraction step: comprising standing…”; “performing a recrystallizing purification step: comprising evaporating…”; and “and performing a recycling step: comprising separating”. Claim 1 recites the limitation "standing the secondary water boiling mother liquor" in the phase separating extraction step. There is insufficient antecedent basis for this limitation in the claim. The claim should read “standing the secondary water boiled mother liquor”. All claims which depend from an indefinite claim are also indefinite. Ex parte Cordova, 10 U.S.P.Q. 2d 1949, 1952 (P.T.O. Bd. App. 1989). Conclusion The prior art made of record and not relied upon is considered pertinent to applicant's disclosure. CN 109180748A is drawn to similar methods herein but do not disclose the secondary water boiling step and forming the secondary water-boiled mother liquor for subsequent phase separation. Further, applicants have shown in embodiments 1-8 that the methods performed with the secondary boiling as claimed herein all show drastic reduction of the white oil content in the products produced compared to methods with only one water boiling step. This extra step, which is not suggested in the prior art, improves the purity of the final product due to the dramatic reduction in white oil content. Any inquiry concerning this communication or earlier communications from the examiner should be directed to TRAVISS C MCINTOSH III whose telephone number is (571)272-0657. The examiner can normally be reached Monday-Friday 9AM-5:30PM EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Scarlett Goon can be reached at 571-270-5241. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /TRAVISS C MCINTOSH III/ Primary Examiner, Art Unit 1693
Read full office action

Prosecution Timeline

Nov 03, 2023
Application Filed
Mar 07, 2026
Non-Final Rejection — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12600741
3-PHENOXYBENZOIC ACID-GLUCURONIC ACID CONJUGATE, AND PREPARATION METHOD AND USE THEREOF
2y 5m to grant Granted Apr 14, 2026
Patent 12595279
MODIFIED NUCLEOSIDE AND SYNTHETIC METHODS THEREOF
2y 5m to grant Granted Apr 07, 2026
Patent 12594286
Novel Immunodulating Small Molecules
2y 5m to grant Granted Apr 07, 2026
Patent 12590115
TECHNOLOGIES USEFUL FOR OLIGONUCLEOTIDE PREPARATION
2y 5m to grant Granted Mar 31, 2026
Patent 12583882
NEW EQUATORIALLY MODIFIED POLYMER LINKED MULTIMERS OF GUANSINE-3', 5'-CYCLIC MONOPHOSPHATES
2y 5m to grant Granted Mar 24, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

AI Strategy Recommendation

Get an AI-powered prosecution strategy using examiner precedents, rejection analysis, and claim mapping.
Powered by AI — typically takes 5-10 seconds

Prosecution Projections

1-2
Expected OA Rounds
73%
Grant Probability
87%
With Interview (+13.9%)
2y 7m
Median Time to Grant
Low
PTA Risk
Based on 1312 resolved cases by this examiner. Grant probability derived from career allow rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month