Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA. Priority This application, filed 12/20/2023 Claims Priority from Provisional Application 63476846 , filed 12/22/2022. Status of Claims Claims 1, 12, 14, 17, 19, 21, 25, 33-34, 36, 39-40, 47, 51, 54, 58, 60, and 117-119 are pending as of the claim set filed on 3/4/24. Claims 2-11, 13, 15-16, 18, 20, 22-24, 26-32, 35, 37-38, 41-46, 48-50, 52-53, 55-57, 59, 61-116, and 120-136 have been canceled. Claims 1, 12, 14, 17, 19, 21, 25, 33-34, 36, 39-40, 47, 51, 54, 58, 60, and 117-119 were examined. Claims 12, 14, and 17 are rejected. Claims 1, 19, 21, 25, 33-34, 36, 39-40, 47, 51, 54, 58, 60, and 117-119 are allowed. Claim Rejections-35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b ) CONCLUSION.— The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the appl icant regards as his invention. Claims 12, 14, and 17 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 12 depends directly from claim 1 and refers to variables R 9 and R 10 . However, claim 1 doesn’t recite these variables. From the claims, it is uncertain if R 9 and R 10 actually refer to a subset of R 8 of claim 1 or not. The claim is indefinite, as claim 12 lacks antecedent basis for R 9 and R 10 . Claims 14 and 17 are similarly rejected as these claims depend directly from claim 12 and don’t provide further clarity. Reasons for Allowable Subject Matter The following is a statement of reasons for the indication of allowable subject matter: the claimed compounds are not taught or suggested by the prior art . Xie et. al., WO 2022174796 A1, cited in the IDS, English equivalent US 20240158369 A1 ; and Xie et. al., WO 2022174765 A1, cited in the IDS (Xie 2 ; English equivalent US 20240182447 ) represent the closest prior art. Xie teaches inhibitors of Wee1 kinase of the following structural formula: . Xie teaches the proviso compound of claim 60, and compound s wherein ring A is a heteroaryl ring. However, the compounds of claim 60 differ by the lack of the -N=S=O(R 1 R 2 ) substituent on ring A, which is required by the compounds taught by Xie. Xie 2 teaches Wee1 kinase inhibitors that share several structural features with compounds of instant claim 1, including a pyrimidine ring bonded via an amine group to a pyridine ring. However, the position corresponding to ring A of Xie 2 is occupied by a tricyclic ring, while ring A of claim 1 must be a mono- or bicyclic ring. Information Disclosure Statement The IDS filed on 1/11/24 has been considered. Correspondence Any inquiry concerning this communication or earlier communications from the examiner should be directed to FILLIN "Examiner name" \* MERGEFORMAT SARAH PIHONAK whose telephone number is FILLIN "Phone number" \* MERGEFORMAT (571)270-7710 . The examiner can normally be reached FILLIN "Work Schedule?" \* MERGEFORMAT Monday-Friday 9:00-5:30 EST . 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Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. FILLIN "Examiner Stamp" \* MERGEFORMAT SARAH . PIHONAK Primary Examiner Art Unit 1627 /SARAH PIHONAK/ Primary Examiner, Art Unit 1627