Last updated: July 17, 2026

Application No. 18/415,550

GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE

Non-Final OA

Filed

Jan 17, 2024

Priority

Jun 21, 2016 — provisional 62/352,968 +2 more

Examiner

MONTANARI, DAVID A

Art Unit

1632

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

Janssen Pharmaceuticals Inc.

OA Round

1 (Non-Final)

Interview Optional

— +49.4% interview lift. Examiner has a relatively high allowance rate (65%); +49.4% interview lift. A written response may suffice.

Based on 760 resolved cases, 2023–2026

Examiner Intelligence

MONTANARI, DAVID A View full profile →

Grants 65% — above average

Career Allowance Rate

494 granted / 760 resolved

+5.0% vs TC avg

Strong +49% interview lift

Without

With

+49.4%

Interview Lift

resolved cases with interview

Typical timeline

3y 9m

Avg Prosecution

37 currently pending

Career history

818

Total Applications

across all art units

Statute-Specific Performance

§101

1.6%

-38.4% vs TC avg

§103

53.8%

+13.8% vs TC avg

§102

10.3%

-29.7% vs TC avg

§112

28.1%

-11.9% vs TC avg

Black line = Tech Center average estimate • Based on career data from 760 resolved cases

Prosecution Timeline

Jan 17, 2024

Application Filed

Apr 29, 2026

Non-Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

17/241,947

Patent 12669506

CANCER DETECTION METHOD USING SENSE OF SMELL OF NEMATODE

5y 2m to grant Granted Jun 30, 2026

18/658,385

Patent 12662657

UNIVERSAL DONOR STEM CELLS AND RELATED METHODS

2y 1m to grant Granted Jun 23, 2026

17/752,505

Patent 12653840

METHODS FOR PRODUCTION OF PLATELETS FROM PLURIPOTENT STEM CELLS AND COMPOSITIONS THEREOF

4y 0m to grant Granted Jun 16, 2026

17/619,614

Patent 12636369

COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES FOR PROTEIN MODULATION AND USES THEREOF

4y 5m to grant Granted May 26, 2026

18/054,860

Patent 12637661

METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS

3y 6m to grant Granted May 26, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2

Expected OA Rounds

65%

Grant Probability

99%

With Interview (+49.4%)

3y 9m (~1y 3m remaining)

Median Time to Grant

Low

PTA Risk

Based on 760 resolved cases by this examiner. Grant probability derived from career allowance rate.