Office Action Predictor
Last updated: April 16, 2026
Application No. 18/432,949

D-AMPHETAMINE COMPOUNDS, COMPOSITIONS, AND PROCESSES FOR MAKING AND USING THE SAME

Final Rejection §112
Filed
Feb 05, 2024
Examiner
AULAKH, CHARANJIT
Art Unit
1621
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Zevra Therapeutics, INC.
OA Round
4 (Final)
81%
Grant Probability
Favorable
5-6
OA Rounds
2y 0m
To Grant
71%
With Interview

Examiner Intelligence

Grants 81% — above average
81%
Career Allow Rate
1407 granted / 1741 resolved
+20.8% vs TC avg
Minimal -9% lift
Without
With
+-9.4%
Interview Lift
resolved cases with interview
Fast prosecutor
2y 0m
Avg Prosecution
54 currently pending
Career history
1795
Total Applications
across all art units

Statute-Specific Performance

§101
1.9%
-38.1% vs TC avg
§103
15.2%
-24.8% vs TC avg
§102
21.0%
-19.0% vs TC avg
§112
42.7%
+2.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1741 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . According to paper filed on Nov. 20, 2025, the applicants have amended claims 1, 19 and 35. Claims 1-15, 17-31, 33-49 and 51-52 are pending in the application. Claim Objections In claims 1, 19 and 35, depression and obesity are listed twice. Response to Arguments Applicant's arguments filed on Nov. 20, 2025 have been fully considered but they are not persuasive regarding enablement rejection of claims 1-15, 18-31, 34-49 and 52 and indefiniteness rejection of claims 1, 19 and 35. The applicants have amended claims as well as filed a declaration to overcome written description rejection. The applicants have also filed terminal disclaimer to overcome ODP rejections. Regarding enablement rejection, the applicants argue on page 28 that the declaration lists several references to address this rejection. The examiner does not agree with this. There is no mention in the declaration for treating depression, bipolar disorders, schizophrenia, major depressive disorder, Tourette syndrome, nervous tics, lethargy and neural insult with amphetamine. The declaration does address treating other diseases with amphetamines mentioned in claims 1, 19 and 35. The examiner also does not agree with applicant’s arguments regarding indefiniteness rejection of claims 1, 19 and 35. The applicants admit that increasing neurotransmitter concentration is a narrow limitation. However, in the same claim, broader limitation followed by narrow limitation renders the claim indefinite as stated in the last office action. Conclusion The enablement rejection of claims 1-15, 18-31, 34-49 and 52 under 35 U.S.C. 112, 1st paragraph is maintained. The indefiniteness rejection of claims 1, 19 and 35 under 35 U.S.C. 112, 2nd paragraph is maintained. Allowable Subject Matter Claims 17, 33 and 51 are objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to CHARANJIT AULAKH whose telephone number is (571)272-0678. The examiner can normally be reached Monday-Friday 7:00-3:30. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Clinton A Brooks can be reached at 571-270-7682. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /CHARANJIT AULAKH/ Primary Examiner, Art Unit 1621
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Prosecution Timeline

Feb 05, 2024
Application Filed
Oct 17, 2024
Non-Final Rejection — §112
Jan 22, 2025
Response Filed
Jan 30, 2025
Final Rejection — §112
May 05, 2025
Request for Continued Examination
May 07, 2025
Response after Non-Final Action
May 18, 2025
Non-Final Rejection — §112
Nov 14, 2025
Applicant Interview (Telephonic)
Nov 14, 2025
Examiner Interview Summary
Nov 20, 2025
Response Filed
Dec 28, 2025
Final Rejection — §112
Mar 31, 2026
Request for Continued Examination
Apr 01, 2026
Response after Non-Final Action

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

5-6
Expected OA Rounds
81%
Grant Probability
71%
With Interview (-9.4%)
2y 0m
Median Time to Grant
High
PTA Risk
Based on 1741 resolved cases by this examiner. Grant probability derived from career allow rate.

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