Prosecution Insights
Last updated: April 19, 2026
Application No. 18/433,770

CRYO-COLLECTION SYSTEMS AND RELATED METHODS AND HYPERPOLARIZER SYSTEMS

Non-Final OA §102
Filed
Feb 06, 2024
Examiner
ZEC, FILIP
Art Unit
3763
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
Polarean Inc.
OA Round
1 (Non-Final)
65%
Grant Probability
Favorable
1-2
OA Rounds
3y 1m
To Grant
79%
With Interview

Examiner Intelligence

Grants 65% — above average
65%
Career Allow Rate
649 granted / 998 resolved
-5.0% vs TC avg
Moderate +14% lift
Without
With
+14.1%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
31 currently pending
Career history
1029
Total Applications
across all art units

Statute-Specific Performance

§101
0.4%
-39.6% vs TC avg
§103
52.1%
+12.1% vs TC avg
§102
23.2%
-16.8% vs TC avg
§112
15.6%
-24.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 998 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . This action is in response to the preliminary amendment filed 2/06/2024. Claims 1-23 and 29 are pending while claims 24-28 and 30-33 are canceled. Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 23 and 29 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by U.S. Patent Application Publication 2002/0069650 to Hasson et al. (Hasson). In reference to claim 23, Hasson teaches a method of collecting hyperpolarized ¹²⁹Xe (par 0006 and 0082), comprising providing a cryo-collection system comprising a dewar (141, FIG. 14) with an internal liquid chamber (140, FIG. 14) chamber comprising liquid and an accumulator (50A, FIG. 14); flowing liquid nitrogen into the chamber to cool the accumulator to a sufficient temperature to freeze and collect hyperpolarized ¹²⁹Xe from a hyperpolarized noble gas mixture (par 0038-0041); then draining the liquid nitrogen from the chamber (via valve 37, FIG. 2B); then flowing heated water into the chamber to heat the collected hyperpolarized ¹²⁹Xe to a sufficient temperature to thaw the collected hyperpolarized ¹²⁹Xe (par 0098 and 0099); and then flowing the thawed hyperpolarized 129 Xe out of the accumulator into an enclosed flow path (par 0084, last sentence). In reference to claim 29, Hasson teaches a dewar for cryo-collection (FIG. 14), comprising a dewar body (141, FIG. 14) enclosing a chamber (50A, FIG. 14); and a drain port (par 0158; port allowing fluid communication between chamber 50A and a valve 28, FIG. 14) in the dewar body (141, FIG. 14) in fluid communication with the chamber (50A, FIG. 14). Allowable Subject Matter Claims 1-22 are allowed. REASONS FOR ALLOWANCE The following is an examiner’s statement of reasons for allowance: The prior art does not anticipate nor render obvious the combination set forth in the independent claim, and specifically does not show a cryo-collection system wherein the system is configured so that the coolant liquid and the heated liquid both serially drain from the chamber through the drain port. Any comments considered necessary by applicant must be submitted no later than the payment of the issue fee and, to avoid processing delays, should preferably accompany the issue fee. Such submissions should be clearly labeled “Comments on Statement of Reasons for Allowance.” Conclusion The prior art made of record and not relied upon is considered pertinent to applicant's disclosure. See attached PTO-892 for relevant prior art. Any inquiry concerning this communication or earlier communications from the examiner should be directed to FILIP ZEC whose telephone number is (571)270-5846. The examiner can normally be reached Mon - Fri; 9-5. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, JD Fletcher can be reached at 5712705054. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /FILIP ZEC/Primary Examiner, Art Unit 3763 1/23/2026
Read full office action

Prosecution Timeline

Feb 06, 2024
Application Filed
Jan 24, 2026
Non-Final Rejection — §102 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
65%
Grant Probability
79%
With Interview (+14.1%)
3y 1m
Median Time to Grant
Low
PTA Risk
Based on 998 resolved cases by this examiner. Grant probability derived from career allow rate.

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