Prosecution Insights
Last updated: July 17, 2026
Application No. 18/441,009

METHOD FOR QUANTITATIVELY DETECTING HYDROQUINONE

Non-Final OA §112
Filed
Feb 14, 2024
Priority
Jul 31, 2023 — CN 202310945671.4
Examiner
MUI, CHRISTINE T
Art Unit
Tech Center
Assignee
Anhui University
OA Round
1 (Non-Final)
78%
Grant Probability
Favorable
1-2
OA Rounds
3m
Est. Remaining
98%
With Interview

Examiner Intelligence

Grants 78% — above average
78%
Career Allowance Rate
1079 granted / 1379 resolved
+18.2% vs TC avg
Strong +20% interview lift
Without
With
+19.8%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
58 currently pending
Career history
1435
Total Applications
across all art units

Statute-Specific Performance

§101
0.3%
-39.7% vs TC avg
§103
81.0%
+41.0% vs TC avg
§102
13.7%
-26.3% vs TC avg
§112
2.4%
-37.6% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1379 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Status of Claims The claim set submitted on 14 FEBRUARY 2024 is acknowledged and considered. In the claim set, Claims 1-3 are presented and are considered on the merits below. Priority Receipt is acknowledged of certified copies of papers required by 37 CFR 1.55. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 1 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. In Claim 1, line 10, the claim recites ‘obtaining the fact’. It unclear to the Examiner how to ‘obtaining the fact’ is to be obtained. It is unclear to the Examiner what ‘obtaining the fact’ is supposed to be doing. Furthermore, it is unclear how this ‘obtaining’ is to be conducted? Is it thorough a visual verification, a mental steps, a pen and paper, just reading data? In Claim 1, in the ‘establishing’ steps, there is a working curve that is generated. However, it is unclear to the Examiner how in a step of ‘establishing a working curve’, and then looking at a linear relationship; how is then a quantitative detection of the hydroquinone determine? Establish a working curve is just that, only a curve is generated. How is one to relate a curve to a quantitative amount. Is there a calculating steps occurring? Furthermore, how is one to determine from a concentration of hydroquinone in the CAT clock reaction system to then determine a quantitative amount? Furthermore, what is meant by ‘achieving’ ? Is what is being performed in the ‘establishing’ step, an ‘achieving’ step is automatically done/performed? Dependent claims follow the same reasoning. Pertinent Prior Art JP 2007006880 A to FUJI discloses a method for measuring an enzyme, capable of giving a result on the spot, without requiring a waiting time due to an induction period, capable of continuously collecting and measuring a sample, and capable of following a change of a concentration of the enzyme in the sample with the lapse of time, and to provide an apparatus for measuring the same. The method for measuring the enzyme comprises utilizing autocatalytic reaction in which the enzyme acts as a catalyst and calculating an amount of the enzyme contained in a sample solution based on a time by which the reaction has rapidly proceeded, wherein the sample solution is mixed with a reagent participating in the autocatalytic reaction, so as to form a mixed solution, the mixed solution is poured into a channel at a prescribed flow rate, the autocatalytic reaction is made to arise in the channel, and the amount of the enzyme contained in the sample solution is calculated based on a state of a change of a color developed in the channel in accordance with the autocatalytic reaction. There is not mention of hydroquinone or the specific CAT clock. CN 113219024 A to ANHUI discloses a method for quantitatively detecting NaClO 4 , which is characterized in that: using a pH clock reaction system of "HCHO-NaHSO 3 -Na 2 SO 3 " as a detection solution, according to the different responses of the system to different concentrations of NaClO 4 , the induction Differences in time enable quantitative analysis of NaClO4 . The quantitative analysis method for NaClO 4 involved in the present invention has the characteristics of high accuracy, easy operation, convenience and quickness, and the like. While there is a mention of a clock system, the reference is silent in regards to hydroquinone and the specific clock in ANHUI is different than what is claimed. It would be non-sensical to merely choose the CAT clock in the instant invention to be used in the ANHUI reference as they are directed to detection of a different target. CN 114923750 A to ANHUI UNIVERSITY teaches the same pH clock reaction system of "HCHO-NaHSO 3 -Na 2 SO 3 " as a detection solution but for the detection of manganous chloride. J. Chem. Educ. 2019, 96, 4, 812–818 to LIMPANUPARB discloses a quantitative determination of compounds using clock system. This reference is merely a background on what clock system do, what they are made of and how they work. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to CHRISTINE T MUI whose telephone number is (571)270-3243. The examiner can normally be reached M-Th 5:30 -15:30 EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, LYLE ALEXANDER can be reached at (571) 272-1254. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. CTM /CHRISTINE T MUI/Primary Examiner, Art Unit 1797
Read full office action

Prosecution Timeline

Feb 14, 2024
Application Filed
Jun 25, 2026
Non-Final Rejection mailed — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12681013
MICROFLUIDIC FLOW CHANNEL STRUCTURE, DETECTION SYSTEM AND METHOD FOR USING SAME
3y 7m to grant Granted Jul 14, 2026
Patent 12678787
DIAGNOSTIC DETECTION CHIP DEVICES AND METHODS OF MANUFACTURE AND ASSEMBLY
3y 4m to grant Granted Jul 14, 2026
Patent 12674806
Endometriosis Biomarkers
3y 10m to grant Granted Jul 07, 2026
Patent 12674809
SPECIMEN ANALYSIS METHOD AND SPECIMEN ANALYZER
3y 6m to grant Granted Jul 07, 2026
Patent 12667846
MICROFLUIDIC DEVICE AND SAMPLE ANALYSIS METHOD
4y 10m to grant Granted Jun 30, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.
Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2
Expected OA Rounds
78%
Grant Probability
98%
With Interview (+19.8%)
2y 8m (~3m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1379 resolved cases by this examiner. Grant probability derived from career allowance rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month