Prosecution Insights
Last updated: October 01, 2026
Application No. 18/447,057

METHOD AGAINST SNAKE ENVENOMATION

Final Rejection §102
Filed
Aug 09, 2023
Priority
Aug 11, 2022 — provisional 63/397,147
Examiner
ROZOF, TIMOTHY R
Art Unit
1625
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
National Tsing Hua University
OA Round
2 (Final)
73%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
96%
With Interview

Examiner Intelligence

Grants 73% — above average
73%
Career Allowance Rate
707 granted / 972 resolved
+12.7% vs TC avg
Strong +24% interview lift
Without
With
+23.6%
Interview Lift
resolved cases with interview
Fast prosecutor
2y 0m
Avg Prosecution
49 currently pending
Career history
998
Total Applications
across all art units

Statute-Specific Performance

§101
2.4%
-37.6% vs TC avg
§103
21.1%
-18.9% vs TC avg
§102
33.2%
-6.8% vs TC avg
§112
25.3%
-14.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 972 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION This is a response to Applicant’s communication filed on June 22, 2026. Application No. 18/447,057, is a U.S. Nonprovisional application filed August 9, 2023, and claim the on benefit of U.S. Provisional application No. 63/397,147, filed August 11, 2022. In an amendment filed June 22, 2026, Applicant added new claim 9. Claims 1-9 are pending. Rejection Withdrawn The rejection of claims 1-8 under 35 U.S.C. 102(a)(1) as being anticipated by Singh et al., A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants, 20(3) J. PHARMACOPUNCTURE 173-178 (2017), is withdrawn in view of Applicant’s June 22, 2026, Amendment & Remarks. New Rejection Necessitated by Applicant’s June 22, 2026, Amendment Claim Rejections - 35 USC § 102(a)(1) The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1-9 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Muhammad Hassham Hassan Bin Asad et al., Anti-venom potential of Pakistani medicinal plants: inhibition of anticoagulation activity of Naja naja karachiensis toxin, 105(10) Current Science 1419-1424 (2013). Asad discloses a method against snake envenomation of a neurotoxic venom (from Naja spp., i.e., Naja naja), comprising administering to a subject in need thereof a composition containing a flavonoid compound being isorhamnetin. See Asad et al., p. 1421, Medicinal plants, Apocynaceae, Botanical name, Rhazya stricta Dcne. Conclusion No claims are allowed. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Contact Information Any inquiry concerning this communication or earlier communications from the examiner should be directed to TIMOTHY R ROZOF whose telephone number is (571)270-5992. The examiner can normally be reached Monday - Friday, 9:00 a.m. -5:00 p.m.. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Andrew Kosar can be reached at (571) 272-0913. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /TIMOTHY R ROZOF/Primary Examiner, Art Unit 1625
Read full office action

Prosecution Timeline

Aug 09, 2023
Application Filed
Mar 24, 2026
Non-Final Rejection mailed — §102
Jun 22, 2026
Response Filed
Aug 10, 2026
Final Rejection mailed — §102 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
73%
Grant Probability
96%
With Interview (+23.6%)
2y 0m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 972 resolved cases by this examiner. Grant probability derived from career allowance rate.

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