Prosecution Insights
Last updated: April 19, 2026
Application No. 18/447,259

METHOD AND APPARATUS FOR DIAGNOSIS AND TREATMENT OF MICROVASCULAR DYSFUNCTION

Non-Final OA §102§112
Filed
Aug 09, 2023
Examiner
FLICK, JASON E
Art Unit
3783
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
Corflow Therapeutics AG
OA Round
1 (Non-Final)
80%
Grant Probability
Favorable
1-2
OA Rounds
3y 1m
To Grant
94%
With Interview

Examiner Intelligence

Grants 80% — above average
80%
Career Allow Rate
733 granted / 914 resolved
+10.2% vs TC avg
Moderate +14% lift
Without
With
+13.5%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
38 currently pending
Career history
952
Total Applications
across all art units

Statute-Specific Performance

§101
0.8%
-39.2% vs TC avg
§103
35.0%
-5.0% vs TC avg
§102
33.6%
-6.4% vs TC avg
§112
19.5%
-20.5% vs TC avg
Black line = Tech Center average estimate • Based on career data from 914 resolved cases

Office Action

§102 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Priority The examiner notes that the application claims benefit to multiple parent applications; specifically, 16/577962 (CON), 17/819580 (CIP), and 17/000240 (CIP). Of these three parent applications, it is noted that support for the claimed limitation of “instructions that, when executed, cause a user interface to display a representation of the sensor data and a change between the first flow rate and the second flow rate” is not present. As such, the instant application is given a priority date of 08/09/2023. Information Disclosure Statement The information disclosure statement (IDS), submitted on 08/09/2023, has been considered by the examiner. Drawings The drawings are objected to under 37 CFR 1.83(a). The drawings must show every feature of the invention specified in the claims. Therefore, the “user interface to display a representation of the sensor data and a change between the first flow rate and the second flow rate” (as recited in claim 1) must be shown or the feature(s) canceled from the claim(s). No new matter should be entered. Corrected drawing sheets in compliance with 37 CFR 1.121(d) are required in reply to the Office action to avoid abandonment of the application. Any amended replacement drawing sheet should include all of the figures appearing on the immediate prior version of the sheet, even if only one figure is being amended. The figure or figure number of an amended drawing should not be labeled as “amended.” If a drawing figure is to be canceled, the appropriate figure must be removed from the replacement sheet, and where necessary, the remaining figures must be renumbered and appropriate changes made to the brief description of the several views of the drawings for consistency. Additional replacement sheets may be necessary to show the renumbering of the remaining figures. Each drawing sheet submitted after the filing date of an application must be labeled in the top margin as either “Replacement Sheet” or “New Sheet” pursuant to 37 CFR 1.121(d). If the changes are not accepted by the examiner, the applicant will be notified and informed of any required corrective action in the next Office action. The objection to the drawings will not be held in abeyance. Specification The specification is objected to as failing to provide proper antecedent basis for the claimed subject matter. See 37 CFR 1.75(d)(1) and MPEP § 608.01(o). Correction of the following is required: The claimed subject matter of “at least one pressure sensor configured to generate sensor data corresponding to a change between a first pressure and a second pressure distal to the balloon” or “instructions that, when executed, cause a user interface to display a representation of the sensor data and a change between the first flow rate and the second flow rate” is not disclosed in the originally filed specification. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 1 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. [Claim 1] The claim recites the limitation of “at least one pressure sensor configured to generate sensor data corresponding to a change between a first pressure and a second pressure distal to the balloon” in the 4th and 5th lines of the claim. The examiner is unable to determine the metes and bounds of the claim, since it is unclear if this limitation refers to when the measurement is taken or where the measured pressures must be located. Furthermore, if the limitation refers to a location of measured pressure, it is unclear if both the “first pressure” and the “second pressure” must be “distal to the balloon,” or if only the “second pressure” is required to be “distal to the balloon.” For purposes of examination, it is interpreted that the limitation refers to a location of measured pressures and that both measured pressures are to be “distal to the balloon.” Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim 1 is rejected under 35 U.S.C. 102(a)(1) as being anticipated by Schwartz et al. (PGPub 2017/0189654). [Claim 1] Schwartz teaches a system (figure 1, item 10) for analyzing flow resistance in a blood vessel (paragraph [0041]), the system comprising: a catheter (figure 1, item 20) comprising a distal region, a proximal region, and a balloon (figure 1, item 22) disposed at the distal region (figure 1), the distal region of the catheter (figure 1, item 20) sized and shaped to be positioned in a blood vessel (figure 6); at least one pressure sensor (figure 6, items 100/102) configured to generate sensor data corresponding to a change between a first pressure and a second pressure distal to the balloon (see 112b interpretation above) (figure 1, item 22) (figure 6; paragraphs [0105], [0107]); a pump assembly (figure 1, item 40) coupled to the proximal region of the catheter (figure 1, item 20) (figure 1), the pump assembly (figure 1, item 40) comprising at least one reservoir (figure 1, item 44) containing injectate (paragraph [0097]), the pump assembly (figure 1, item 40) configured to pump injectate from the at least one reservoir (figure 1, item 44) through the catheter (figure 1, item 20) at a first flow rate and a second flow rate (paragraphs [0036], [0050], [0058], [0098]); and instructions that, when executed, cause a user interface (figure 14; “sample data lab displays”) to display a representation of the sensor data (figure 14, item “Pd”) and a change between the first flow rate and the second flow rate (figure 14, item “Q”) (figure 14; paragraphs [0064], [0066], [0146], [0147]). Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to JASON E FLICK whose telephone number is (571)270-7024. The examiner can normally be reached M-F 7 a.m.-3 p.m. Eastern Time. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Bhisma Mehta can be reached at 571-272-3383. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JASON E FLICK/Primary Examiner, Art Unit 3783 02/10/2026
Read full office action

Prosecution Timeline

Aug 09, 2023
Application Filed
Jan 23, 2026
Non-Final Rejection — §102, §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12582769
SYSTEMS AND METHODS FOR DETECTING DISRUPTIONS IN FLUID DELIVERY DEVICES
2y 5m to grant Granted Mar 24, 2026
Patent 12580076
MEDICAL DEVICE HAVING COMMMUNICATION FUNCTION AND COMMUNICATION SYSTEM
2y 5m to grant Granted Mar 17, 2026
Patent 12576204
SYSTEMS AND METHODS FOR DELIVERING A FLUID TO A PATIENT WITH REDUCED CONTAMINATION
2y 5m to grant Granted Mar 17, 2026
Patent 12564434
DEVICES AND METHODS FOR FLUID DISTRIBUTION FROM A CATHETER
2y 5m to grant Granted Mar 03, 2026
Patent 12564679
ADJUSTING MEDICAMENT DELIVERY PARAMETERS IN AN OPEN LOOP MEDICAMENT DELIVERY MODE
2y 5m to grant Granted Mar 03, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

AI Strategy Recommendation

Get an AI-powered prosecution strategy using examiner precedents, rejection analysis, and claim mapping.
Powered by AI — typically takes 5-10 seconds

Prosecution Projections

1-2
Expected OA Rounds
80%
Grant Probability
94%
With Interview (+13.5%)
3y 1m
Median Time to Grant
Low
PTA Risk
Based on 914 resolved cases by this examiner. Grant probability derived from career allow rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month