Prosecution Insights
Last updated: July 17, 2026
Application No. 18/447,907

BIOCOMPATIBLE OXYGEN-SENSITIVE MATERIALS

Non-Final OA §102§112
Filed
Aug 10, 2023
Priority
Aug 11, 2022 — provisional 63/397,209
Examiner
BERKELEY, EMILY R
Art Unit
1796
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Promega Corporation
OA Round
1 (Non-Final)
76%
Grant Probability
Favorable
1-2
OA Rounds
2m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 76% — above average
76%
Career Allowance Rate
314 granted / 413 resolved
+11.0% vs TC avg
Strong +28% interview lift
Without
With
+28.0%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
26 currently pending
Career history
437
Total Applications
across all art units

Statute-Specific Performance

§101
2.0%
-38.0% vs TC avg
§103
68.4%
+28.4% vs TC avg
§102
12.2%
-27.8% vs TC avg
§112
12.7%
-27.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 413 resolved cases

Office Action

§102 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . The applicant's election of Group I, claims 1-15, 17-19 and 21, without traverse in their reply dated 4/10/2026 is acknowledged. Claims 16, 20, and 23-47 were cancelled. Claim 22 wase withdrawn. Claims 1-15,17-19 and 21 are considered on the merits below. Information Disclosure Statement The Information Disclosure Statements filed on 3/13/2024 and 9/26/2024 are in compliance with the provisions of 37 CFR 1.97 and have been considered. An initialed copy of the Form 1449 is enclosed herewith. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-15, 17-19, and 21 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Regarding claim 1, the claim is indefinite because there are two compounds listed formula (I) and formula (II) without indicating an “and” or an “or” between them. It is unclear if both are required or just one. For examination purposes the examiner interprets there is an “or” between the limitations. Dependent claims follow the same reasoning. Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 1-7 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Huang et al. (US 2015/0323868 A1, provided on the IDS on 3/13/2024). Regarding claims 1, 2, 3, 4, 5, and 6, Huang describes a polysiloxane matrix (page 2 “Polysiloxane (A)…”) comprising: (a) a bis(trialkoxysilyl) monomer of formula (I): PNG media_image1.png 162 282 media_image1.png Greyscale R1, R1’, R1”, R2, R2', and R2"are independently selected from CH3, CH2CH3, (CH2)2CH3, wherein L is selected from C1-C6 alkyl, C1-C6 heteroalkyl, C2-C6 alkenyl, C2-C6 heteroalkenyl, C2-C6 alkynyl, C1-C6 heteroalkynyl, PNG media_image2.png 160 256 media_image2.png Greyscale wherein L' and L" are independently selected from, a covalent bond, C1-C6 alkyl or heteroalkyl, C2-C6 alkenyl or heteroalkenyl, C2-C6 alkynyl or heteroalkynyl, wherein L' and L2 are independently selected aryl or heteroaryl rings, wherein L' and L2 are linked by a covalent bond, and wherein L, L', L", and L' and L2 are optionally branched or substituted ([0034] PNG media_image3.png 410 432 media_image3.png Greyscale ); OR (b) a dialkyldialkoxysilane monomer of formula (II): PNG media_image4.png 90 158 media_image4.png Greyscale wherein R3, R3', R4, and R4'are independently selected from CH3, CH2CH3, and (CH2)2CH3. Regarding claim 7, Huang describes the polysiloxane matrix of claim 1, wherein the bis(trialkoxysilyl) monomer is 1,4- bis(trimethoxysilylethyl)benzene and the dialkyldialkoxysilane monomer is dimethyldimethoxysilane ([0033] “1,4-bis(trimethoxysilylmethyl)benzene,”). Allowable Subject Matter Claims 8-15, 17-19 and 21 would be allowable if rewritten to overcome the rejection(s) under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), 2nd paragraph, set forth in this Office action and to include all of the limitations of the base claim and any intervening claims. The following is a statement of reasons for the indication of allowable subject matter: Reference Huang et al. (US 2015/0323868 A1, provided on the IDS on 3/13/2024) describe most of the limitations of claim 1, however fail to teach or suggest the subject matter of claim 8: “A composition comprising the polysiloxane matrix of claim 1 and an oxygen-sensitive fluorophore”. None of the prior art discovered describes all the limitations alone or in combination, thus the prior art fails to teach or suggest all the limitations of claims 8-15, 17-19 and 21. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to EMILY R BERKELEY whose telephone number is (571)272-9831. The examiner can normally be reached M-Th 9-6. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Lyle Alexander can be reached at (571) 272-1254. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /LYLE ALEXANDER/Supervisory Patent Examiner, Art Unit 1797 /EMILY R. BERKELEY/ Examiner Art Unit 1796
Read full office action

Prosecution Timeline

Aug 10, 2023
Application Filed
Jun 05, 2026
Non-Final Rejection mailed — §102, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
76%
Grant Probability
99%
With Interview (+28.0%)
3y 1m (~2m remaining)
Median Time to Grant
Low
PTA Risk
Based on 413 resolved cases by this examiner. Grant probability derived from career allowance rate.

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