Last updated: August 06, 2026

Application No. 18/461,179

INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF

Non-Final OA

Filed

Sep 05, 2023

Priority

Apr 17, 2020 — provisional 63/012,039 +13 more

Examiner

MCDOWELL, BRIAN E

Art Unit

1624

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

Pardes Biosciences Inc.

OA Round

3 (Non-Final)

Interview Optional

— +30.4% interview lift. Interview already conducted in this application's prosecution history. This examiner has a 74% grant rate with +30.4% interview lift. Since an interview has already been tried, recommend written response with narrowed claims based on precedent claim evolution patterns.

Based on 1124 resolved cases, 2023–2026

Examiner Intelligence

MCDOWELL, BRIAN E View full profile →

Grants 74% — above average

Career Allowance Rate

834 granted / 1124 resolved

+14.2% vs TC avg

Strong +30% interview lift

Without

With

+30.4%

Interview Lift

resolved cases with interview

Typical timeline

2y 2m

Avg Prosecution

69 currently pending

Career history

1177

Total Applications

across all art units

Statute-Specific Performance

§101

1.0%

-39.0% vs TC avg

§103

16.6%

-23.4% vs TC avg

§102

20.2%

-19.8% vs TC avg

§112

49.8%

+9.8% vs TC avg

Black line = Tech Center average estimate • Based on career data from 1124 resolved cases

Prosecution Timeline

Sep 05, 2023

Application Filed

Apr 22, 2025

Non-Final Rejection mailed

Oct 22, 2025

Response Filed

Dec 18, 2025

Final Rejection mailed

Jun 18, 2026

Request for Continued Examination

Jun 22, 2026

Response after Non-Final Action

Jul 22, 2026

Examiner Interview (Telephonic)

Jul 27, 2026

Non-Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

18/003,758

Patent 12698283

QUINOLINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS, AND METHODS OF USE THEREOF

3y 7m to grant Granted Aug 04, 2026

17/883,933

Patent 12691129

USE OF CAROTENOIDS IN THE TREATMENT OF SENESCENCE-RELATED DISEASES

3y 11m to grant Granted Jul 28, 2026

18/323,939

Patent 12673920

INHIBITORS OF NLRP3 INFLAMMASOME

3y 1m to grant Granted Jul 07, 2026

17/629,344

Patent 12667101

PICOLINAMIDE DERIVATIVES USEFUL AS AGRICULTURAL FUNGICIDES

4y 5m to grant Granted Jun 30, 2026

18/692,791

Patent 12668586

AHR INHIBITOR, USE THEREOF, AND PREPARATION METHOD THEREFOR

2y 3m to grant Granted Jun 30, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

3-4

Expected OA Rounds

74%

Grant Probability

99%

With Interview (+30.4%)

2y 2m (~0m remaining)

Median Time to Grant

High

PTA Risk

Based on 1124 resolved cases by this examiner. Grant probability derived from career allowance rate.