Last updated: August 06, 2026

Application No. 18/470,548

PCSK9 INHIBITORS AND METHODS OF USE THEREOF

Non-Final OA

Filed

Sep 20, 2023

Priority

Sep 23, 2022 — provisional 63/376,791 +2 more

Examiner

JACKSON, SHAWQUIA

Art Unit

1626

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

Astrazeneca AB

OA Round

1 (Non-Final)

Interview Optional

— -3.4% interview lift. Interview lift (-3.4%) is below the 15.0% threshold. A written response is recommended.

Based on 1822 resolved cases, 2023–2026

Examiner Intelligence

JACKSON, SHAWQUIA View full profile →

Grants 78% — above average

Career Allowance Rate

1420 granted / 1822 resolved

+17.9% vs TC avg

Minimal -3% lift

Without

With

+-3.4%

Interview Lift

resolved cases with interview

Typical timeline

2y 3m

Avg Prosecution

50 currently pending

Career history

1851

Total Applications

across all art units

Statute-Specific Performance

§101

2.6%

-37.4% vs TC avg

§103

15.0%

-25.0% vs TC avg

§102

18.0%

-22.0% vs TC avg

§112

50.7%

+10.7% vs TC avg

Black line = Tech Center average estimate • Based on career data from 1822 resolved cases

Prosecution Timeline

Sep 20, 2023

Application Filed

Mar 11, 2026

Non-Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

18/206,316

Patent 12692237

CONTINUOUS METHOD FOR PREPARING TRICYANOIMIDAZOLE

3y 1m to grant Granted Jul 28, 2026

18/611,683

Patent 12692242

METHOD FOR PREPARING FLURALANER

2y 4m to grant Granted Jul 28, 2026

18/369,177

Patent 12685311

NOVEL ENVIRONMENTALLY FRIENDLY BIOCIDAL QUATERNIZED AMINE COMPOUND

2y 10m to grant Granted Jul 21, 2026

18/590,523

Patent 12686668

LEUKOTRIENE SYNTHESIS INHIBITORS

2y 4m to grant Granted Jul 21, 2026

18/020,492

Patent 12668571

SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28

3y 4m to grant Granted Jun 30, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

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Prosecution Projections

1-2

Expected OA Rounds

78%

Grant Probability

74%

With Interview (-3.4%)

2y 3m (~0m remaining)

Median Time to Grant

Low

PTA Risk

Based on 1822 resolved cases by this examiner. Grant probability derived from career allowance rate.