Prosecution Insights
Last updated: April 19, 2026
Application No. 18/489,064

METHOD FOR ALLEVIATING DRY EYE DISEASE

Non-Final OA §102§103
Filed
Oct 18, 2023
Examiner
BOECKELMAN, JACOB A
Art Unit
1655
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Bioray Biotech Co. Ltd.
OA Round
1 (Non-Final)
36%
Grant Probability
At Risk
1-2
OA Rounds
3y 1m
To Grant
83%
With Interview

Examiner Intelligence

Grants only 36% of cases
36%
Career Allow Rate
86 granted / 237 resolved
-23.7% vs TC avg
Strong +46% interview lift
Without
With
+46.5%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
96 currently pending
Career history
333
Total Applications
across all art units

Statute-Specific Performance

§101
13.6%
-26.4% vs TC avg
§103
52.1%
+12.1% vs TC avg
§102
12.3%
-27.7% vs TC avg
§112
16.6%
-23.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 237 resolved cases

Office Action

§102 §103
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim 1 is rejected under 35 U.S.C. 102(a)(1) as being anticipated by Huang Hexing (CN115969889A). Regarding claims 1 and 4, Hexing discloses an application of the extract of the fruiting body of cordyceps militaris is characterized in that the extract is used for preparing a medicine for improving the blue light damage resistance effect; wherein the extract of the Cordyceps militaris sporocarp (aka fruiting body) is obtained by extracting a Cordyceps militaris sporocarp sample by using an ethanol water solution (see claim 1). With the broadest reasonable interpretation an ethanol aqueous extract would also be an ethanol extract when so broadly claimed as they both include ethanol. Hexing discloses orally administering the composition (see claims 6-8). Hexing does not disclose that the method is for alleviating dry eye disease, however discloses that the method is for improving damage caused to the eyes from blue light, which is known to cause dry eyes as a symptom and thus the patient populations would be the same. Additionally, the administration of the same ethanol extract of the fruiting bodies of the same species of fungi would inherently have the same effects. Claim Rejections - 35 USC § 103 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. This application currently names joint inventors. In considering patentability of the claims the examiner presumes that the subject matter of the various claims was commonly owned as of the effective filing date of the claimed invention(s) absent any evidence to the contrary. Applicant is advised of the obligation under 37 CFR 1.56 to point out the inventor and effective filing dates of each claim that was not commonly owned as of the effective filing date of the later invention in order for the examiner to consider the applicability of 35 U.S.C. 102(b)(2)(C) for any potential 35 U.S.C. 102(a)(2) prior art against the later invention. Claims 1-4 are rejected under 35 U.S.C. 103 as being unpatentable over Huang Hexing (CN115969889A) and Wei Chih-Hao (TW201932122A). Regarding claims 1 and 4, Hexing discloses an application of the extract of the fruiting body of cordyceps militaris is characterized in that the extract is used for preparing a medicine for improving the blue light damage resistance effect; wherein the extract of the Cordyceps militaris sporocarp (aka fruiting body) is obtained by extracting a Cordyceps militaris sporocarp sample by using an ethanol water solution (see claim 1). With the broadest reasonable interpretation an ethanol aqueous extract would also be an ethanol extract when so broadly claimed as they both include ethanol. Hexing discloses orally administering the composition (see claims 6-8). Hexing does not disclose that the method is for alleviating dry eye disease, however discloses that the method is for improving damage caused to the eyes from blue light, which is known to cause dry eyes as a symptom and thus the patient populations would be the same. Additionally, the administration of the same ethanol extract of the fruiting bodies of the same species of fungi would inherently have the same effects. Chih-Hao teaches that an ethanol extract of Cordyceps militaris is used for preparing eye-protection compositions (see abstract) and teaches that the extract is from the fruiting bodies (see page 3, para. 1-3) and teaches the composition is for treating dry eye syndrome (see page 4, para. 2-4). Therefore it would have been obvious to persons having ordinary skill in the art and before the effective filing date to use the invention taught by Hexing and/or Chih-Hao for a method of treating dry eye because that is exactly what the inventions are directed to. The same administration of the same components and to the same patient population would ultimately have the same effects. Additionally, it would have been obvious to use the method of treating dry eyes for the causes listed in claims 2 and 3 because Chih-Hao teaches the use of the same composition for treating dry eye syndrome and it is not so limited to any particular cause. The benefits of treating dry eyes would be made obvious to use for different causes of dry eyes because the symptom which is dry eye is the same in each case. There would have been a reasonable expectation of success in arriving at the instant invention given the prior art because both pieces of art are directed to the ethanol extracted Cordyceps militaris compositions which are given as a composition to protect eyes and to treat dry eyes. Conclusion No claims are allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to JACOB ANDREW BOECKELMAN whose telephone number is (571)272-0043. The examiner can normally be reached Monday-Friday 8am-5pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Terry McKelvey can be reached at 571-272-0775. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. JACOB A BOECKELMAN Examiner, Art Unit 1655 /TERRY A MCKELVEY/ Supervisory Patent Examiner, Art Unit 1655
Read full office action

Prosecution Timeline

Oct 18, 2023
Application Filed
Nov 17, 2025
Non-Final Rejection — §102, §103 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
36%
Grant Probability
83%
With Interview (+46.5%)
3y 1m
Median Time to Grant
Low
PTA Risk
Based on 237 resolved cases by this examiner. Grant probability derived from career allow rate.

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