Prosecution Insights
Last updated: April 19, 2026
Application No. 18/491,871

MODIFIED RELEASE FORMULATIONS OF PRIDOPIDINE

Non-Final OA §103§112
Filed
Oct 23, 2023
Examiner
PIPIC, ALMA
Art Unit
1617
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Prilenia Neurotherapeutics Ltd.
OA Round
4 (Non-Final)
55%
Grant Probability
Moderate
4-5
OA Rounds
3y 1m
To Grant
99%
With Interview

Examiner Intelligence

Grants 55% of resolved cases
55%
Career Allow Rate
380 granted / 696 resolved
-5.4% vs TC avg
Strong +57% interview lift
Without
With
+56.9%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
57 currently pending
Career history
753
Total Applications
across all art units

Statute-Specific Performance

§101
0.7%
-39.3% vs TC avg
§103
40.6%
+0.6% vs TC avg
§102
10.2%
-29.8% vs TC avg
§112
32.2%
-7.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 696 resolved cases

Office Action

§103 §112
-DETAILED ACTION- Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Continued Examination Under 37 CFR 1.114 A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant’s submission filed on January 13, 2026 has been entered. Priority This application is a CON of 16/115,105 filed on 08/28/2018, which is a CON of 14/601,920 filed on 01/21/2015, which claims benefit in provisional application 62/050,626 filed on 09/15/2014 and claims benefit in provisional application 61/930,358 filed on 01/22/2014. This application repeats a substantial portion of prior Application No. 16/115,105, filed 08/28/2018, and adds disclosure not presented in the prior application. Because this application names the inventor or at least one joint inventor named in the prior application, it may constitute a continuation-in-part of the prior application. Should applicant desire to claim the benefit of the filing date of the prior application, attention is directed to 35 U.S.C. 120, 37 CFR 1.78, and MPEP § 211 et seq. The presentation of a benefit claim may result in an additional fee under 37 CFR 1.17(w)(1) or (2) being required, if the earliest filing date for which benefit is claimed under 35 U.S.C. 120, 121, 365(c), or 386(c) and 1.78(d) in the application is more than six years before the actual filing date of the application. Claims 1-7 filed on October 23, 2023 do not have support in any of the priority documents. Thus, the effective filing date of claims 1-7 is October 23, 2023. Pages 27-29 of the specification describe a method of making pridopidine granules where all granulation ingredients are added to the granulator bowl and pre-blend for a sufficient time to ensure uniformity. Granulations liquid was added and blend. Tables 3.1, 3.2, and 3.3 describe the ingredients. The specification does not describe any other methods of making a granule or a tablet, including the claimed tablet. Claim Status Claims 1-7 are pending and examined. Claim 1 was amended. Withdrawn Claim Rejections - 35 USC § 103 Rejections of claims 1-3 and 5-7 over Waters (US 2013/0267552 Al Published October 10, 2013 - of record in IDS dated 01/28/2024), Staniforth (US 5,741,524 Date of Patent April 21, 1998), Singla (WO 2012/172461 Al Published December 20, 2012), and Nangia (US 2010/0316712 Al Publication Date December 16, 2010) and rejection of claim 4 over Waters, Staniforth, Singla, Nangia, and Ryoshi are withdrawn because the claims were amended to require the wet granulation step to exclude a rate controlling excipient, and this limitation would not have been obvious over the cited references. Arguments filed against these rejections are moot because rejections are withdrawn. Claim Rejections – 35 USC § 112 The following is a quotation of the first paragraph of 35 U.S.C. 112(a): (a) IN GENERAL.—The specification shall contain a written description of the invention, and of the manner and process of making and using it, in such full, clear, concise, and exact terms as to enable any person skilled in the art to which it pertains, or with which it is most nearly connected, to make and use the same, and shall set forth the best mode contemplated by the inventor or joint inventor of carrying out the invention. The following is a quotation of the first paragraph of pre-AIA 35 U.S.C. 112: The specification shall contain a written description of the invention, and of the manner and process of making and using it, in such full, clear, concise, and exact terms as to enable any person skilled in the art to which it pertains, or with which it is most nearly connected, to make and use the same, and shall set forth the best mode contemplated by the inventor of carrying out his invention. Claims 1-7 are rejected under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, as failing to comply with the written description requirement. The claim(s) contains subject matter which was not described in the specification in such a way as to reasonably convey to one skilled in the relevant art that the inventor or a joint inventor, or for applications subject to pre-AIA 35 U.S.C. 112, the inventor(s), at the time the application was filed, had possession of the claimed invention. Claim 1 was amended to require step (a) to exclude a rate controlling excipient in the wet granulation step. This limitation is new matter because it is not supported in the application as originally filed. Applicant’s reply does not state where the limitation is supported. Pages 27-29 of the specification describe a method of making pridopidine granules where all granulation ingredients are added to the granulator bowl and pre-blend for a sufficient time to ensure uniformity. Granulations liquid was added and blend. Tables 3.1, 3.2, and 3.3 describe the ingredients used to make the granule compositions. The specification does not describe any other methods of making a granule or a tablet, including the claimed tablet. Therefore, the newly added limitation is not supported in the application as filed. Claims 2-7 are rejected for new matter because the claims depend from claim 1. Conclusion No claims are allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Alma - Pipic whose telephone number is (571)270-7459. The examiner can normally be reached M-F 9:00am-5:00pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner's supervisor, Michael Hartley can be reached on 571-272-0616. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ALMA PIPIC/Primary Examiner, Art Unit 1617
Read full office action

Prosecution Timeline

Oct 23, 2023
Application Filed
Jul 09, 2024
Non-Final Rejection — §103, §112
Oct 06, 2024
Response Filed
Oct 22, 2024
Final Rejection — §103, §112
Apr 24, 2025
Response after Non-Final Action
Apr 24, 2025
Request for Continued Examination
Apr 28, 2025
Response after Non-Final Action
Aug 16, 2025
Final Rejection — §103, §112
Nov 04, 2025
Interview Requested
Nov 17, 2025
Examiner Interview Summary
Dec 17, 2025
Response after Non-Final Action
Dec 17, 2025
Response after Non-Final Action
Jan 13, 2026
Request for Continued Examination
Jan 13, 2026
Response after Non-Final Action
Jan 16, 2026
Response after Non-Final Action
Mar 20, 2026
Non-Final Rejection — §103, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

4-5
Expected OA Rounds
55%
Grant Probability
99%
With Interview (+56.9%)
3y 1m
Median Time to Grant
High
PTA Risk
Based on 696 resolved cases by this examiner. Grant probability derived from career allow rate.

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