Prosecution Insights
Last updated: April 17, 2026
Application No. 18/493,531

METHODS TO INHIBIT OSTEOPOROSIS THROUGH IMPLANTATION

Non-Final OA §101
Filed
Oct 24, 2023
Examiner
RESTAINO, ANDREW PETER
Art Unit
3771
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
unknown
OA Round
1 (Non-Final)
73%
Grant Probability
Favorable
1-2
OA Rounds
2y 10m
To Grant
99%
With Interview

Examiner Intelligence

Grants 73% — above average
73%
Career Allow Rate
188 granted / 257 resolved
+3.2% vs TC avg
Strong +42% interview lift
Without
With
+42.2%
Interview Lift
resolved cases with interview
Typical timeline
2y 10m
Avg Prosecution
57 currently pending
Career history
314
Total Applications
across all art units

Statute-Specific Performance

§101
0.9%
-39.1% vs TC avg
§103
41.0%
+1.0% vs TC avg
§102
23.5%
-16.5% vs TC avg
§112
27.1%
-12.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 257 resolved cases

Office Action

§101
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Objections Claims 3 and 5 are objected to because of the following informalities: Claim 3 recites “upto” in line 1, however this is not grammatically correct, thus the Examiner suggests the line be amended to read “up to”; Claim 5 recites “wherein implanting the nitrogen” in line 1, although the line is understood by the Examiner to mean “wherein the step of implanting nitrogen” as the “implanting” step was previously defined, the Examiner suggests the line be amended to read “wherein the step of implanting nitrogen” for the purpose of maintaining consistent language throughout the claims; Appropriate correction is required. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Section 33(a) of the America Invents Act reads as follows: Notwithstanding any other provision of law, no patent may issue on a claim directed to or encompassing a human organism. Claim 1 is rejected under 35 U.S.C. 101 and section 33(a) of the America Invents Act as being directed to or encompassing a human organism. See also Animals - Patentability, 1077 Off. Gaz. Pat. Office 24 (April 21, 1987) (indicating that human organisms are excluded from the scope of patentable subject matter under 35 U.S.C. 101). Claim 1 positively requires a “bone”, which is a type of human tissue (i.e., a human organism); therefore, claim 1 is seen as being directed to a human organism. Allowable Subject Matter Claims 2 – 6 are allowed. The following is an examiner’s statement of reasons for allowance: the prior art alone or in combination with fails to disclose or make obvious the method of implanting nitrogen into a bone and then heating the bone with the implanted nitrogen. The closest prior art, Webster et al (US 2014/0302109 A1), discloses a method for treating a bone defect comprising the step of implanting nitrogen in a bone injury / defect (paragraphs [0009], [0017], [0019], and claim 1). However, Webster does not disclose or make obvious the method step of heating the bone with the implanted nitrogen. Furthermore, it would not have been obvious to one of ordinary skill in the art to modify the method of treating a bone defect of Webster to include the step of heating the bone because there is no motivation to do so. Additionally, no other references, or reasonable combination thereof, could be found which discloses or suggests these features in combination with other limitations in the claims. Any comments considered necessary by applicant must be submitted no later than the payment of the issue fee and, to avoid processing delays, should preferably accompany the issue fee. Such submissions should be clearly labeled “Comments on Statement of Reasons for Allowance.” Conclusion The prior art made of record and not relied upon is considered pertinent to applicant's disclosure: Chu et al (US 2009/0270422 A1) teaches a method of treating a bone defect with a compound including nitrogen. Contact Information Any inquiry concerning this communication or earlier communications from the examiner should be directed to Andrew Restaino whose telephone number is (571)272-4748. The examiner can normally be reached Mon - Fri 8:00 - 4:00 ET. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Elizabeth Houston can be reached at 571-272-7134. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /Andrew Restaino/Primary Examiner, Art Unit 3771
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Prosecution Timeline

Oct 24, 2023
Application Filed
Feb 06, 2026
Non-Final Rejection — §101 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
73%
Grant Probability
99%
With Interview (+42.2%)
2y 10m
Median Time to Grant
Low
PTA Risk
Based on 257 resolved cases by this examiner. Grant probability derived from career allow rate.

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