Last updated: July 17, 2026

Application No. 18/495,538

METHODS AND COMPOSITIONS TO REGULATE CHOLESTEROL EFFLUX TO PREVENT, TREAT, OR CURE MACULAR DEGENERATION

Non-Final OA

Filed

Oct 26, 2023

Priority

Apr 27, 2021 — provisional 63/180,201 +1 more

Examiner

SHIN, DANA H

Art Unit

1635

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

The Trustees of Columbia University in the City of New York

OA Round

1 (Non-Final)

This examiner grants 27% of cases after interview

— +27.5% interview lift. A telephonic interview to clarify the technical implementation could significantly improve the outcome.

Based on 1160 resolved cases, 2023–2026

Examiner Intelligence

SHIN, DANA H View full profile →

Grants only 27% of cases

Career Allowance Rate

314 granted / 1160 resolved

-32.9% vs TC avg

Strong +28% interview lift

Without

With

+27.5%

Interview Lift

resolved cases with interview

Typical timeline

3y 3m

Avg Prosecution

77 currently pending

Career history

1250

Total Applications

across all art units

Statute-Specific Performance

§101

6.0%

-34.0% vs TC avg

§103

37.1%

-2.9% vs TC avg

§102

5.6%

-34.4% vs TC avg

§112

19.3%

-20.7% vs TC avg

Black line = Tech Center average estimate • Based on career data from 1160 resolved cases

Prosecution Timeline

Oct 26, 2023

Application Filed

May 28, 2026

Non-Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

18/224,017

Patent 12667586

TREATMENTS FOR OCULAR SURFACE DISORDERS

2y 11m to grant Granted Jun 30, 2026

16/474,686

Patent 12624068

EXON SKIPPING BY PEPTIDE NUCLEIC ACID DERIVATIVES

6y 10m to grant Granted May 12, 2026

16/966,506

Patent 12617841

NUCLEIC ACID ANTIBODY CONSTRUCTS FOR USE AGAINST RESPIRATORY SYNCYTIAL VIRUS

5y 9m to grant Granted May 05, 2026

18/058,000

Patent 12612656

PARTICLE-BASED ISOLATION OF PROTEINS AND OTHER ANALYTES

3y 5m to grant Granted Apr 28, 2026

18/177,446

Patent 12582723

NOVEL POLYNUCLEOTIDES ENCODING A HUMAN FKRP PROTEIN

3y 0m to grant Granted Mar 24, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2

Expected OA Rounds

27%

Grant Probability

55%

With Interview (+27.5%)

3y 3m (~7m remaining)

Median Time to Grant

Low

PTA Risk

Based on 1160 resolved cases by this examiner. Grant probability derived from career allowance rate.