Prosecution Insights
Last updated: April 19, 2026
Application No. 18/500,431

SYSTEMS AND METHODS FOR TREATING DISEASE THROUGH PERIPHERAL NERVE STIMULATION

Non-Final OA §103
Filed
Nov 02, 2023
Examiner
HULBERT, AMANDA K
Art Unit
3792
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
Cala Health Inc.
OA Round
3 (Non-Final)
84%
Grant Probability
Favorable
3-4
OA Rounds
3y 3m
To Grant
88%
With Interview

Examiner Intelligence

Grants 84% — above average
84%
Career Allow Rate
626 granted / 743 resolved
+14.3% vs TC avg
Minimal +4% lift
Without
With
+3.7%
Interview Lift
resolved cases with interview
Typical timeline
3y 3m
Avg Prosecution
32 currently pending
Career history
775
Total Applications
across all art units

Statute-Specific Performance

§101
3.3%
-36.7% vs TC avg
§103
39.3%
-0.7% vs TC avg
§102
27.9%
-12.1% vs TC avg
§112
22.7%
-17.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 743 resolved cases

Office Action

§103
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Continued Examination Under 37 CFR 1.114 A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on February 23, 2026 has been entered. Currently claims 15-21 and 35-42 are pending in this application. Response to Arguments Applicant's arguments filed February 23, 2026 have been fully considered but they are not persuasive inasmuch as they apply to the amended rejections required by the amendments to the claims. Examiner notes that Tai treats inflammatory bowel disease, which is an inflammatory condition. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. Claims 15-18, 36-37, and 42 are rejected under 35 U.S.C. 103 as being unpatentable over Tai (US 2013/0006322, as previously cited) in view of Hershey (US 2015/005852). Regarding claim 15 and 37, Tai discloses a wearable device for dual transcutaneous stimulation of a first peripheral nerve and a second peripheral nerve for treating inflammatory (e.g. two channel system; [0042] treatment of inflammatory gastrointestinal disorders; [0024]); a controller (e.g. controller 30 as shown in Figure 1); a first peripheral nerve effector, comprising at least one stimulation electrode configured to be positioned to transcutaneously modulate the first peripheral nerve (e.g. electrode 14 as shown in Figure 1); a second peripheral nerve effector, comprising at least one stimulation electrode configured to be positioned to transcutaneously modulate the second peripheral nerve (e.g. electrode 15 as shown in Figure 1); and deliver the first electrical stimulus to the first peripheral nerve through the first peripheral nerve effector and deliver the second electrical stimulus to the second peripheral nerve through the second peripheral nerve effector to reduce inflammatory disease symptoms based on the feedback information (e.g. delivery of stimulation via electrode 1 and 2 as shown in Figure 3), providing feedback information (e.g. feedback and adjustment capability of the system as described in [0042]), wherein the controller comprises a processor and a memory for receiving the feedback information from the sensor that, when executed by the processor, cause the device to: adjust one or more parameters of a first electrical stimulus and a second electrical stimulus based at least in part on the feedback information (e.g. adjustment capability of the system as described in [0042]), wherein the device is not configured for implantation within the patient (e.g. as shown in Figure 3; Title); and wherein the first electrical stimulus and the second electrical stimulus each have a frequency between 1 Hz and 100 Hz (e.g. stimulation using two channel system as described in [0042] wherein stimulation is between 1 and 500 Hz, and more specifically “1 to 50 Hz, 50 to 20 Hz or approximately 5 Hz”, which is in the range of 1 to 100 Hz (claim 15) and 5 to 200 HZ (claim 37) [0009]). While Tai does disclose generically using feedback to control the system, Tai does not expressly disclose a biomedical sensor or data input source including instructions for adjusting parameters based on the feedback information. Hershey discloses that it was well known in the art of stimulation to include a biomedical sensor to collect feedback information and adjust the parameters based on the feedback information (e.g. adjustment of stimulation based on sensed paramaters as disclosed in [0018]). It would have been obvious to one having ordinary skill in the art to include the biomedical sensor and feedback system of Hershey in the device of Tai since such a modification would provide the system with the predictable results of a reliable means of providing stimulation. Regarding claim 16, Tai additionally discloses wherein the first peripheral nerve is a tibial nerve (e.g. as described in [0030]). Tai does not expressly disclose a second peripheral nerve is a sapheous nerve, but the claim is an apparatus claim and the two nerves are close together, the device of Tai is capable of performing the functional limitation of stimulating the tibial nerve. Regarding claims 17-18, Tai additionally discloses stimulation between 10 Hz and 20 Hz and between 5 Hz and 30 Hz. (e.g. stimulation using two channel system as described in [0042] wherein stimulation is between 1 and 500 Hz, and more specifically “1 to 50 Hz, 50 to 20Hz or approximately 5 Hz”, which is in the range of 1 to 100 Hz, [0009]). Regarding claims 36 and 42, Hershey additionally disclose stimulating the vagus nerve (e.g. as disclosed in [0024] – [0030]) Claims 19-21 and 38-40 are rejected under 35 U.S.C. 103 as being unpatentable over Tai and Hershey in further view of Yoo (US 2015/0148878, as previously cited). Regarding claims 19-21 and 38-40, Tai discloses the claimed invention except the express mention that the feedback information comprises autonomic nervous system activity of the patient, heart rate variability, or information relating to inflammatory biomarker levels of the patient, but rather discloses the use of a wide variety of non-limiting physiological parameters such as blood pressure, acidic concentration, and/or temperature. Yoo teaches that it was well known in the art of stimulators for treating gastrointestinal problems to measure autonomic nervous system activity of the patient, heart rate variability, or information relating to inflammatory biomarker levels of the patient (e.g. sensor data that is processed by processor 58; [0346]). It would have been obvious to one having ordinary skill in the art at the time the invention was made to include the sense feedback data of Yoo in the device of Tai since such a modification would provide the system with the predictable results of a reliable means of controlling the stimulation. Claims 35 and 41 are rejected under 35 U.S.C. 103 as being unpatentable over Tai and Hershey in further view of Burnett (US 11,224,742). Regarding claim 35 and 41, Tai and Hershey disclose the claimed invention except the express mention of the disease is selected from colitis, rheumatoid arthritis, and multiple sclerosis. Burnett discloses that it was well known the art of electrical stimulation to treat various conditions to treat arthritis (e.g. as disclosed in Col. 6, lines 30-45). It would have been obvious to one having ordinary skill in the art to include the treatment of arthritis as taught by Burnett in the device of Tai and Hershey in order to provide the system with the predictable results of a reliable means of treating a wide variety of conditions. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to Amanda K Hulbert whose telephone number is (571)270-1912. The examiner can normally be reached Monday - Friday 9:00-5:00. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Unsu Jung can be reached at 571-272-8506. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /Amanda K Hulbert/ Primary Examiner, Art Unit 3792
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Prosecution Timeline

Nov 02, 2023
Application Filed
Jun 27, 2025
Non-Final Rejection — §103
Sep 30, 2025
Response Filed
Oct 07, 2025
Final Rejection — §103
Feb 23, 2026
Request for Continued Examination
Mar 14, 2026
Response after Non-Final Action
Mar 20, 2026
Non-Final Rejection — §103 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
84%
Grant Probability
88%
With Interview (+3.7%)
3y 3m
Median Time to Grant
High
PTA Risk
Based on 743 resolved cases by this examiner. Grant probability derived from career allow rate.

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