Prosecution Insights
Last updated: April 17, 2026
Application No. 18/509,447

METHOD FOR PRODUCING LIPOSOMES ENTRAPPING CYCLOSPORINE A

Non-Final OA §112
Filed
Nov 15, 2023
Examiner
LIPPERT, JOHN WILLIAM
Art Unit
1615
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
unknown
OA Round
1 (Non-Final)
55%
Grant Probability
Moderate
1-2
OA Rounds
3y 6m
To Grant
97%
With Interview

Examiner Intelligence

Grants 55% of resolved cases
55%
Career Allow Rate
74 granted / 134 resolved
-4.8% vs TC avg
Strong +42% interview lift
Without
With
+42.2%
Interview Lift
resolved cases with interview
Typical timeline
3y 6m
Avg Prosecution
68 currently pending
Career history
202
Total Applications
across all art units

Statute-Specific Performance

§101
1.6%
-38.4% vs TC avg
§103
58.9%
+18.9% vs TC avg
§102
8.9%
-31.1% vs TC avg
§112
24.5%
-15.5% vs TC avg
Black line = Tech Center average estimate • Based on career data from 134 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Summary Claims 1-9 are pending in this office action. All pending claims are under examination in this application. The Examiner called the attorney of record, Haris Bajwa, on October 17, 2025 and was informed that the application is currently being reassigned. No authorization could be obtained for an Examiner’s amendment. Therefore, the office is issuing a Non-Final Rejection. Priority The current application was filed on November 15, 2023 is a 371 of PCT/IB2022/054573 filed May 17, 2022, which in turn claims domestic priority to provisional patent application 63/189,229 filed on May 17, 2021. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-9 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 1 needs to use the lower-case form of cyclosporine A. Additionally, claim 1 needs a hyphen between alpha tocopherol (alpha-tocopherol). In a similar manner, claim 2 also needs to use the lower-case form of cyclosporine A. Furthermore, since the Applicant has defined the acronym for cyclosporine A (CsA) in claim 1. The acronym can be optionally used within the claim. Dependent claims 3-9 fail to cure the defect of claim 2. Claim 4 has the text “1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-PEG conjugate.” It should be written “1,2-distearoyl-sn-glycero-3-phosphoethanolamine-PEG conjugate.” Appropriate correction is required. Conclusion No claims are allowed. [No prior art was identified for rejection purposes. To proceed to allowance, the 35 U.S.C. §112(b) rejections must be resolved by the Applicant.] Any inquiry concerning this communication or earlier communications from the examiner should be directed to JOHN W LIPPERT III whose telephone number is (571)270-0862. The examiner can normally be reached Monday - Thursday 9:00 AM - 5:00 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Robert A Wax can be reached on 571-272-0623. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JOHN W LIPPERT III/Examiner, Art Unit 1615 /Robert A Wax/Supervisory Patent Examiner, Art Unit 1615
Read full office action

Prosecution Timeline

Nov 15, 2023
Application Filed
Oct 20, 2025
Non-Final Rejection — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12599557
LIPOSOMAL SUSTAINED-RELEASE COMPOSITIONS CONTAINING A THERAPEUTIC DRUG AND USE THEREOF
2y 5m to grant Granted Apr 14, 2026
Patent 12593841
ANTIMICROBIAL MIXTURE CONTAINING 4-(3-ETHOXY-4-HYDROXYPHENYL)BUTAN-2-ONE AND AN ARGINATE COMPOUND, AND COSMETIC COMPOSITION CONTAINING SAME
2y 5m to grant Granted Apr 07, 2026
Patent 12569415
GEL-TYPE COSMETIC
2y 5m to grant Granted Mar 10, 2026
Patent 12569438
NANOMATERIALS CONTAINING CONSTRAINED LIPIDS AND USES THEREOF
2y 5m to grant Granted Mar 10, 2026
Patent 12569448
MEMBRANE-BASED TWO COMPONENT THERAPEUTIC GAS RELEASE SYSTEM FOR ORAL ADMINISTRATION
2y 5m to grant Granted Mar 10, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
55%
Grant Probability
97%
With Interview (+42.2%)
3y 6m
Median Time to Grant
Low
PTA Risk
Based on 134 resolved cases by this examiner. Grant probability derived from career allow rate.

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