Prosecution Insights
Last updated: July 17, 2026
Application No. 18/532,794

METHODS AND APPARATUS FOR PERFORMING ELECTROCHEMICAL AND ENZYMATIC REACTIONS

Non-Final OA §112
Filed
Dec 07, 2023
Priority
Dec 07, 2022 — provisional 63/430,735
Examiner
RIPA, BRYAN D
Art Unit
Tech Center
Assignee
The University of British Columbia
OA Round
1 (Non-Final)
53%
Grant Probability
Moderate
1-2
OA Rounds
1y 2m
Est. Remaining
91%
With Interview

Examiner Intelligence

Grants 53% of resolved cases
53%
Career Allowance Rate
286 granted / 537 resolved
-6.7% vs TC avg
Strong +37% interview lift
Without
With
+37.4%
Interview Lift
resolved cases with interview
Typical timeline
3y 9m
Avg Prosecution
37 currently pending
Career history
571
Total Applications
across all art units

Statute-Specific Performance

§101
0.6%
-39.4% vs TC avg
§103
71.3%
+31.3% vs TC avg
§102
9.2%
-30.8% vs TC avg
§112
11.2%
-28.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 537 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Rejections - 35 USC § 112(b) The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 3 and 11 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 3 recited the limitations “the substrate” and “the enzyme” in lines 1-2 of the claim. However, claim 2 – the claim from which claim 3 depends – sets forth “a supply of enzymes and substrates” (see claim 2). As such, claim 2 seems to require a plurality of enzymes and substrates but claim 3 only refers to “the substrate” and “the enzyme” and so it is unclear if only a part of the early set forth enzymes and substrates are being further limited or if it is the entirety of the enzymes and substrates that are to be further limited. Claim 11 recites the limitation “the substrates” and “the enzymes” in lines 1-2 of the claim. However, there is insufficient antecedent basis for this limitation in the claim since claim 3 sets forth “the substrate” and “the enzyme” (see claim 3 at lines 1-2). Allowable Subject Matter Claims 1-20 would all be allowable if rewritten to overcome the rejection(s) under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), 2nd paragraph, set forth in this Office action. The following is a statement of reasons for the indication of allowable subject matter: The closest prior art is US Pub. No. 2021/0040017 to Berlinguette et al., (hereinafter referred to as “BERLINGUETTE”). While BERLINGUETTE teaches that it is known in the art to have an electrochemical cell with a metallic membrane cathode that is hydrogen selective (see BERLINGUETTE at Abstract and Fig. 1A), BERLINGUETTE is silent, nor would it fairly suggest, the method as claimed related to a coupled electrochemical and enzymatic reaction including the steps as claimed in independent claims 1 and 20. As such, it is the examiner’s opinion that the prior art neither teaches nor fairly suggests the methods as claimed. Conclusion The prior art made of record and not relied upon is considered pertinent to applicant's disclosure. US Pub. No. 2024/0102177 to Bau et al., teaching an electrochemical cofactor regeneration using earth abundant electrodes for biocatalytic applications US Pub. No. 2023/0183873 to Huang et al., teaching a method and apparatus for producing hydrogen peroxide using a metallic membrane cathode US Pub. No. 2023/0158459 to Berlinguette et al., teaching hydrogen permeable membranes, reactors, and related methods US Pub. No. 2017/0335473 to Armiger et al., teaching an improved electrochemical bioreactor module and use thereof Any inquiry concerning this communication or earlier communications from the examiner should be directed to Bryan D. Ripa whose telephone number is (571)270-7875. The examiner can normally be reached Mon-Fri 8:00AM-4:00PM ET. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, James Lin can be reached at (571) 272-8902. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRYAN D. RIPA/Primary Patent Examiner, Art Unit 1794
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Prosecution Timeline

Dec 07, 2023
Application Filed
Jun 17, 2026
Non-Final Rejection mailed — §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
53%
Grant Probability
91%
With Interview (+37.4%)
3y 9m (~1y 2m remaining)
Median Time to Grant
Low
PTA Risk
Based on 537 resolved cases by this examiner. Grant probability derived from career allowance rate.

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