Last updated: July 17, 2026

Application No. 18/552,141

SYNTHETIC INTERMEMBRANE PROTEOLYSIS RECEPTORS FOR CUSTOM ANTIGEN-INDUCED TRANSCRIPTIONAL REGULATION

Non-Final OA

Filed

Sep 22, 2023

Priority

Mar 23, 2021 — provisional 63/164,995 +1 more

Examiner

NICKOL, GARY B

Art Unit

1643

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

The Regents of the University of California

OA Round

1 (Non-Final)

This examiner grants 44% of cases after interview

— +28.2% interview lift. A telephonic interview to clarify the technical implementation could significantly improve the outcome.

Based on 61 resolved cases, 2023–2026

Examiner Intelligence

NICKOL, GARY B View full profile →

Grants 44% of resolved cases

Career Allowance Rate

27 granted / 61 resolved

-15.7% vs TC avg

Strong +28% interview lift

Without

With

+28.2%

Interview Lift

resolved cases with interview

Typical timeline

3y 9m

Avg Prosecution

43 currently pending

Career history

100

Total Applications

across all art units

Statute-Specific Performance

§101

1.8%

-38.2% vs TC avg

§103

27.4%

-12.6% vs TC avg

§102

22.4%

-17.6% vs TC avg

§112

27.9%

-12.1% vs TC avg

Black line = Tech Center average estimate • Based on career data from 61 resolved cases

Prosecution Timeline

Sep 22, 2023

Application Filed

Apr 13, 2026

Non-Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

17/055,252

Patent 12679887

ANTI-INTERLEUKIN-17A ANTIBODY, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF

5y 8m to grant Granted Jul 14, 2026

17/914,027

Patent 12678461

CD28H DOMAIN-CONTAINING CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE

3y 9m to grant Granted Jul 14, 2026

18/271,946

Patent 12678494

Immunogenic Composition Comprising Multivalent Streptococcus Pneumoniae Polysaccharide-Protein Conjugates

3y 0m to grant Granted Jul 14, 2026

17/726,839

Patent 12674803

DIAGNOSIS OF BABESIA USING BABESIA RECOMBINANT PROTEINS

4y 2m to grant Granted Jul 07, 2026

19/205,170

Patent 12668627

NOVEL CYTOKINE-BASED THERAPIES AND METHODS

1y 1m to grant Granted Jun 30, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2

Expected OA Rounds

44%

Grant Probability

72%

With Interview (+28.2%)

3y 9m (~11m remaining)

Median Time to Grant

Low

PTA Risk

Based on 61 resolved cases by this examiner. Grant probability derived from career allowance rate.