Prosecution Insights
Last updated: August 16, 2026
Application No. 18/563,449

METHOD FOR ACCELERATING ENZYME REACTION

Non-Final OA §103
Filed
Nov 22, 2023
Priority
May 28, 2021 — JP 2021-090160 +3 more
Examiner
OGDEN JR, NECHOLUS
Art Unit
1761
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Kao Corporation
OA Round
3 (Non-Final)
70%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
93%
With Interview

Examiner Intelligence

Grants 70% — above average
70%
Career Allowance Rate
728 granted / 1043 resolved
+4.8% vs TC avg
Strong +23% interview lift
Without
With
+23.3%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
42 currently pending
Career history
1074
Total Applications
across all art units

Statute-Specific Performance

§101
1.5%
-38.5% vs TC avg
§103
48.0%
+8.0% vs TC avg
§102
19.5%
-20.5% vs TC avg
§112
14.6%
-25.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1043 resolved cases

Office Action

§103
Continued Examination Under 37 CFR 1.114 A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on 7-1-2026 has been entered. Claim Rejections - 35 USC § 103 Claim(s) 12, 13 is/are rejected under 35 U.S.C. 103 as being unpatentable over JP 2015199941A. JP ‘941 discloses he liquid detergent composition of the present invention contains the compound (A) represented by the general formula (1) and the protease (B). According to the liquid detergent composition of the present invention, it is possible to clean stains on tableware or cooking utensils. <Compound (A) Represented by General Formula (1)> The compound (A) in the liquid detergent composition of the present invention is represented by the following general formula (1). This compound (A) moves to the vicinity of the protein in the oil phase together with a cleaning base such as protease (B), and is presumed to have a function of improving the cleaning performance for the protein in the soil substance. More specifically, the compound (A) enters the oil phase in the composite soiled substance from the aqueous phase with the cleaning base, and transports the cleaning base to the protein in the soiled material for cleaning. It is presumed that the effect of the base is more easily generated. ##STR2## (In the formula, R .sup.1 and R .sup.2 each independently represent a hydrogen atom or an alkyl group having 5 to 18 carbon atoms, and at least one of R .sup.1 and R .sup.2 is an alkyl group having 5 to 18 carbon atoms. A .sup.1 and A .sup.2 each independently represent an alkylene group having 2 or more and 4 or less carbon atoms, x and y each independently represents an integer of 0 or more and 6 or less, and M .sup.1 is: Represents a hydrogen atom or a cation.) R .sup.1 and R .sup.2 in the general formula (1) are each independently a hydrogen atom or an alkyl group having 5 to 18 carbon atoms. The number of carbon atoms of R .sup.1 and R .sup.2 is 5 or more, preferably 6 or more, from the viewpoint of improving the cleaning performance and from the viewpoint of improving the transfer performance from the aqueous phase to the oil phase in the composite dirt substance. Specific examples of R .sup.1 and R .sup.2 include various pentyl groups, various hexyl groups, various heptyl groups, various octyl groups, various nonyl groups, various decyl groups, various undecyl groups, various dodecyl groups, various tridecyl groups, and various tetradecyl groups (pages 2-3). Specific examples of the compound (A) include, for example, di (2-ethylhexyl) sodium sulfosuccinate, di (1,3-dimethylbutyl) sodium sulfosuccinate, dicyclohexylsodium sulfosuccinate, di (1- Methylheptyl) sodium sulfosuccinate, di (monooxyethylene-2-ethylhexyl) sodium sulfosuccinate, diisodecylsodium sulfosuccinate and the like. Among these, at least one selected from di (2-ethylhexyl) sodium sulfosuccinate and di (monooxyethylene-2-ethylhexyl) sodium sulfosuccinate is preferable, and di (2-propylheptyl) sodium sulfosuccinate is more preferred in the examples. The content of the compound (A) in the liquid detergent composition is preferably 0.05% by mass or more, more preferably from the viewpoint of improving the cleaning performance and from the viewpoint of improving the transfer performance from the aqueous phase to the oil phase. (pages 3-4). JP ‘941 further disclose an enzyme component (B), the protease (B) in the liquid detergent composition of the present invention is used for degrading proteins contained in dirt and improving cleaning performance. As the protease (B), a protease (alkaline protease) having an optimum pH from neutral to alkaline side is preferable. The content of the protease (B) in the liquid detergent composition is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and still more preferably 0.1% from the viewpoint of improving the cleaning performance. % By mass or more, more preferably 0.12% by mass or more, and preferably 0.5% by mass or less, more preferably 0.4% by mass or less, more preferably from the viewpoint of the balance between production cost and effect. Preferably it is 0.3 mass% or less, More preferably, it is 0.2 mass% or less. In the present invention, the content of protease (B) in the liquid detergent composition is the amount of enzyme protein, and the ratio of protease (B) described below to other components is based on the amount of enzyme protein. See also para 0010, 0012 and 0037; examples. As the surfactant (D), a nonionic surfactant can be used. The content of the surfactant (D) in the liquid detergent composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, still more preferably 1% by mass or more, and still more preferably 2%. As a solvent constituting the liquid detergent composition, water, ethanol, polyethylene glycol, polypropylene glycol, ethylene glycol and mixtures thereof. From the viewpoint of improving the stability of the composition, the amount of the solvent in the liquid detergent composition is preferably 10% by mass or more. In a liquid cleaning composition, the other component which can be used for a normal cleaning agent can be mix | blended. Examples include pH adjusters, alkali agents, enzyme stabilizers such as calcium salts and formic acid, fragrances, antibacterial agents, antifungal agents, and dyes. Moreover, the washing | cleaning method of the tableware or cooking utensil of this invention is a method of wash | cleaning without applying mechanical force using the said liquid detergent composition. According to the cleaning method of the present invention, it is not necessary to manually wash the dishes using a flexible material such as sponge, or even if it is hand-washed, it can be washed with the degree of light rinsing. In the present invention, “without applying mechanical force” means not applying mechanical force by a dishwasher or hand washing. That is, according to the cleaning method of the present invention, it is possible to perform cleaning with a force sufficient to bring rinsing water into contact with tableware or cooking utensils. (see entire document for precise line numbers due to translation). JP ‘941 disclose the specific sulfosuccinic branched alkyl ester (a); enzyme (b) and additional components such as nonionic surfactant and solvent (see above). The ratio of components are broadly defined and would readily be optimized to suggest the claimed proportions given that optimization is within the level of ordinary skill. The method of accelerating an enzyme reaction by contacting said enzyme on a substrate is suggested by broadly including said composition on hard surfaces as suggested by JP ‘941 where the skilled artisan would envision said enzymes and sulfosuccinic alkyl ester contacting dishware to suggest said reaction (see examples). One skilled in the art would further expect the compositions and methods of JP ‘941 to adhere to said articles and further suggest utilizing fibrous articles as an option to cleanse said articles (see above). With respect to the limitation of claim 25, where contacting said composition in a method of dishwashing, JP ‘941 is clear in their attempt to utilize said composition for non-mechanical cleansing, however, as the specification and teachings suggest and direct that said dishwashing and hand cleansing with sponges are optional and therefore would suggest to the skilled artisan that it is possible to cleanse by non-mechanical force but other methods are permissible. [W]hen a patent 'simply arranges old elements with each performing the same function it had been known to perform' and yields no more than one would expect from such an arrangement, the combination is obvious. [KSR Int'l Co. v.Teleflex Inc., 550 U.S. at 418 (quoting Sakraida v. Ag Pro, Inc., 425 U.S. 273,282 (1976).] “The normal desire of scientists or artisans to improve upon what is already generally known provides the motivation to determine where in a disclosed set of percentage ranges is the optimum combination of percentages” Peterson, 315 F.3d at 1330, 65 USPQ2d at 1382; In re Hoeschele, 406 F.2d 1403, 160 USPQ 809 (CCPA 1969) Merck & Co. Inc. v. Biocraft Laboratories Inc., 874 F.2d 804, 10 USPQ2d 1843 (Fed. Cir.), cert. denied, 493 U.S. 975 (1989); In re Kulling, 897 F.2d 1147, 14 USPQ2d 1056 (Fed. Cir. 1990); and In re Geisler, 116 F.3d 1465, 43 USPQ2d 1362 (Fed. Cir. 1997). Claim(s) 20 and 25 is/are rejected under 35 U.S.C. 103 as being unpatentable over JP 2015199941A in view of Okamura et al WO 2017204149 are withdrawn. Response to Arguments Applicant's arguments filed 7-1-2026 have been fully considered but they are not persuasive. Applicant argues that Tables 1 and 3 show better result of sulfosuccinates with branched alkyls at 9 or 10 versus those exemplified in JP ‘941. The examiner contends that the working examples of applicants specification are not commensurate in scope with the claims to proffer criticality against the prior art and the prima facie case of obviousness. Specifically, Tables 1 and 3 show a specific sodium bis 2-propylheptyl sulfosuccinate; with enzymes such as protease; adjunct ingredients and additional surfactant sodium dodecyl sulfate. The most comprehensive claims 12-13 are drawn to a singular or binary composition of an additional surfactant without enzymes to accelerate a reaction. Criticality cannot be established since the claims are not commensurate in scope. Whether the unexpected results are the result of unexpectedly improved results or a property not taught by the prior art, the “objective evidence of nonobviousness must be commensurate in scope with the claims which the evidence is offered to support.” In other words, the showing of unexpected results must be reviewed to see if the results occur over the entire claimed range. In re Clemens, 622 F.2d 1029, 1036, 206 USPQ 289, 296 (CCPA 1980) Allowable Subject Matter Claims 1, 3-4, 6, 9-11, 15-16, 19-21, 24-25 are allowed. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to NECHOLUS OGDEN JR whose telephone number is (571)272-1322. The examiner can normally be reached 8-4:30 EST M-F. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Angela Brown-Pettigrew can be reached at 571-272-1498. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /NECHOLUS OGDEN JR/Primary Examiner, Art Unit 1761
Read full office action

Prosecution Timeline

Show 3 earlier events
Feb 13, 2026
Applicant Interview (Telephonic)
Feb 18, 2026
Response Filed
Apr 01, 2026
Final Rejection mailed — §103
Jun 25, 2026
Applicant Interview (Telephonic)
Jun 25, 2026
Examiner Interview Summary
Jul 01, 2026
Request for Continued Examination
Jul 02, 2026
Response after Non-Final Action
Jul 15, 2026
Non-Final Rejection mailed — §103 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
70%
Grant Probability
93%
With Interview (+23.3%)
2y 8m (~0m remaining)
Median Time to Grant
High
PTA Risk
Based on 1043 resolved cases by this examiner. Grant probability derived from career allowance rate.

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