DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA. Information Disclosure Statement The information disclosure statement (IDS) submitted is in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statement is being considered by the examiner. Claim Objections Claims 1 and 43 are objected to because of the following informalities: Regarding claim 1 , it is recommended to amend the claim to recite “ a plane of a first sheet” and “ a plane of a second sheet” in lines 2 and 3, respectively. Regarding claim 1, it is recommended to amend the claim to recite “the first and second sheets overlie one another” in line 4 to correct for spelling. Regarding claim 43 , it is recommended to amend the claim to recite “ a plane of a first sheet” and “ a plane of a second sheet” in lines 2 and 4, respectively. Appropriate correction is required. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b ) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the appl icant regards as his invention. Claims 38 and 50 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Regarding claims 38 and 50 , the claims recite that the microneedles “ lie in a plane perpendicular to the plane of the first and second sheet and parallel to the direction of relative displacement between the first and second sheets ”. Claims 1 and 43, from which claims 38 and 50 depend, respectively, recite that the direction of displacement is parallel to the plane of the first and second sheets. As such, it is unclear how the microneedles can be both perpendicular to the plane of the first/second sheets and parallel to the direction of relative displacement. Allowable Subject Matter Claims 1, 28-37, 39-49, and 51-53 are allowed over the prior art of record. The following is an examiner’s statement of reasons for allowance: The claims in this application are allowed because the prior art of record fails to disclose either singly or in combination the claimed microneedle system and method of manufacturing the microneedle system. The closest prior art of record is Bertollo (US 20190314012 ). Regarding independent claims 1 and 43 , Bertollo fails to teach among all the limitations or render obvious at least some of the microneedles are folded out of the plane of the first or second sheet about a fold axis that extends parallel to the direction of relative displacement between the first and second arrays of microneedles , in combination with the total structure and function as claimed. Bertollo teaches a substantially similar microneedle system and associated method of manufacture (figs. 22a-d). Specifically, Bertollo discloses a first array of microneedles (see below) formed from and folded out of the plane of a first sheet (first section 814 in fig. 22a); a second array of microneedles (see below) formed from and folded out of the plane of a second sheet (second section 816 in fig. 22a); the first and second sheets overly one another (fig. 22a-d) and the second array of microneedles extends through an array of openings in the first sheet to be interspersed with the first array of microneedles (see the three openings formed by dotted line below; figs. 22a-b shows the second array below as extending through the openings) ; wherein the first array of microneedles is displaceable relative to the second array of microneedles in a direction parallel to the plane of the first and second sheets (fig. 22a-b shows the sections 814 and 816 moving horizontally which is a direction parallel to the plane of the sections 814 and 816). Bertollo further discloses that at least some of the microneedles are folded out of the plane of the first or second sheet about a fold axis (see below). However, as seen below, this fold axis is perpendicular to the direction of relative displacement between the first and second arrays of microneedles (see below), and not parallel , as required by the claim. Any comments considered necessary by applicant must be submitted no later than the payment of the issue fee and, to avoid processing delays, should preferably accompany the issue fee. Such submissions should be clearly labeled “Comments on Statement of Reasons for Allowance.” Conclusion The prior art made of record and not relied upon is considered pertinent to applicant's disclosure. See PTO-892 for additional references which disclose microneedles are formed from and folded out of first and second sheets and in which the first and second sheets overlie each other . 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