Prosecution Insights
Last updated: September 17, 2026
Application No. 18/574,867

NOVEL PLK1 PROTEIN DEGRADATION-INDUCING COMPOUND

Non-Final OA §102
Filed
Dec 28, 2023
Priority
Jun 30, 2021 — RE 10-2021-0085980 +1 more
Examiner
JAVANMARD, SAHAR
Art Unit
1622
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
UPPTHERA
OA Round
1 (Non-Final)
65%
Grant Probability
Moderate
1-2
OA Rounds
1m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 65% of resolved cases
65%
Career Allowance Rate
486 granted / 750 resolved
+4.8% vs TC avg
Strong +34% interview lift
Without
With
+34.1%
Interview Lift
resolved cases with interview
Typical timeline
2y 10m
Avg Prosecution
37 currently pending
Career history
784
Total Applications
across all art units

Statute-Specific Performance

§101
1.1%
-38.9% vs TC avg
§103
46.7%
+6.7% vs TC avg
§102
14.6%
-25.4% vs TC avg
§112
16.3%
-23.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 750 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Status of the Claims This Office Action is in response to Applicant's Restriction Requirement remarks filed on April 16, 2026. Claim(s) 1-4 are pending. Claim(s) 4 is withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Applicant's election of Group I drawn to a compound represented by Formula I without traverse of the restriction requirement in the reply is acknowledged. The requirement is deemed proper and is therefore made FINAL. Claim(s) 1-3 are examined herein insofar as they read on the elected invention and species. The elected species was found free of the art, therefore the search was expanded to a genus encompassing Formula I in its entirety. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale or otherwise available to the public before the effective filing date of the claimed invention. Claims 1-3 are rejected under 35 U.S.C. 102 (a)(1) as being anticipated by Mu (Biochemical and Biophysical Research Communications, 2020) of record. Mu teaches the following compounds and pharmaceutical compositions thereof as potentially useful therapeutics in the treatment of cancer (abstract; page 835, Figure 1). PNG media_image1.png 126 374 media_image1.png Greyscale HLB-4 is compound 2 in claim 2. HBL-5 is also embraced by Formula I of claim 1. Based on the foregoing reasons, the instant claims are deemed anticipated over the cited art. Pertinent Prior Art Not Cited CN 109879877-teaches the same two compounds above. Conclusion Claims 1-3 are not allowed. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Sahar Javanmard whose telephone number is (571)270-3280. The examiner can normally be reached on Monday-Friday, 9:00-5:00 EST. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, James Alstrum-Acevedo can be reached on 571-272-5548. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. /SAHAR JAVANMARD/Primary Examiner, Art Unit 1622
Read full office action

Prosecution Timeline

Dec 28, 2023
Application Filed
Jun 26, 2026
Non-Final Rejection mailed — §102 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12723044
HETEROCYCLIC SUBSTITUTED FUSED y-CARBOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF
3y 5m to grant Granted Sep 01, 2026
Patent 12715846
CRYSTAL FORM OF QUINOLINONE COMPOUND AND USE THEREOF
4y 2m to grant Granted Aug 25, 2026
Patent 12715847
ANTIBACTERIAL COMPOUNDS
3y 0m to grant Granted Aug 25, 2026
Patent 12708619
USE OF PRIDOPIDINE FOR TREATING ANXIETY AND DEPRESSION
3y 10m to grant Granted Aug 18, 2026
Patent 12709620
COMPOUND FOR ADJUSTING ACTIVITY OF NMDA RECEPTOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
3y 9m to grant Granted Aug 18, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.
Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2
Expected OA Rounds
65%
Grant Probability
99%
With Interview (+34.1%)
2y 10m (~1m remaining)
Median Time to Grant
Low
PTA Risk
Based on 750 resolved cases by this examiner. Grant probability derived from career allowance rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month