Prosecution Insights
Last updated: April 19, 2026
Application No. 18/575,198

COMPOSITION FOR TREATMENT OF AUTOIMMUNE DISEASES COMPRISING LACTOBACILLUS SAKEI OR EXTRACELLULAR VESICLES DERIVED THEREFROM AS ACTIVE INGREDIENT

Non-Final OA §102
Filed
Dec 28, 2023
Examiner
DAVIS, BRIAN J
Art Unit
1614
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Liscure Biosciences Inc.
OA Round
2 (Non-Final)
85%
Grant Probability
Favorable
2-3
OA Rounds
1y 11m
To Grant
80%
With Interview

Examiner Intelligence

Grants 85% — above average
85%
Career Allow Rate
1317 granted / 1549 resolved
+25.0% vs TC avg
Minimal -5% lift
Without
With
+-4.8%
Interview Lift
resolved cases with interview
Fast prosecutor
1y 11m
Avg Prosecution
47 currently pending
Career history
1596
Total Applications
across all art units

Statute-Specific Performance

§101
4.0%
-36.0% vs TC avg
§103
16.0%
-24.0% vs TC avg
§102
19.4%
-20.6% vs TC avg
§112
43.6%
+3.6% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1549 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . 112 Rejections Withdrawn The rejection of claims 13-21 under 35 USC 112(a) or 35 USC 112 (pre-AIA ), first paragraph, outlined in the previous Office Action, has been overcome by inventor’s amendment. With respect to claims 18 and 19, the amendment cancels the claims. With respect to the remaining claims, the amendment narrows the scope of the claimed subject matter such that it is now enabled. 102 Rejections Withdrawn The rejection of claims 13, 14 and 20 under 35 USC 102(a)(1), outlined in the previous Office Action, has been overcome by inventor’s amendment. The amendment narrows the scope of the claimed subject matter such that it no longer reads on the cited art. Claim Rejections - 35 USC § 102, NEW In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim 21 is rejected under 35 U.S.C. 102(a)(1) as being clearly anticipated by Bioscience of Microbiota, Food and Health (2019), 38(1), pp. 23-29. The reference teaches a method of preparing a composition comprising a step of preparing membrane vesicles (i.e. extracellular vesicles) derived from a Lactobacillus sakei subspecies (abstract). The examiner notes that the intended use of the instant composition (“…for alleviating or treating an autoimmune disease…” can be given no patentable weight because where the claimed and prior art products are identical or substantially identical in structure or composition, or are produced by identical or substantially identical processes, a prima facie case of either anticipation or obviousness has been established. In the instant case, the instant claimed method step of preparing the composition is identical to that of the prior art method, and the composition thus prepared must necessarily exhibit the same properties. (MPEP 2112.01 (I).) This rejection should have been included in the previous Office Action. The examiner regrets the inconvenience to applicant. Allowable Subject Matter Claims 13-17, 20 and 22 are allowed. The following is a statement of reasons for the indication of allowable subject matter: The closest prior art remains the prior art of record. During the course of prosecution, inventor has narrowed the scope of the claimed subject matter such that it no longer reads on the cited art. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to BRIAN J DAVIS whose telephone number is (571)272-0638. The examiner can normally be reached M-F 8:30-5:00 PM EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Ali Soroush, can be reached at 571-272-9925. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRIAN J DAVIS/Primary Examiner, Art Unit 1614 2/3/2026
Read full office action

Prosecution Timeline

Dec 28, 2023
Application Filed
Sep 30, 2025
Non-Final Rejection — §102
Jan 02, 2026
Response Filed
Feb 03, 2026
Non-Final Rejection — §102 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
85%
Grant Probability
80%
With Interview (-4.8%)
1y 11m
Median Time to Grant
Moderate
PTA Risk
Based on 1549 resolved cases by this examiner. Grant probability derived from career allow rate.

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