Prosecution Insights
Last updated: April 19, 2026
Application No. 18/575,799

COMPOSITION COMPRISING HYDRANGENOL AS ACTIVE INGREDIENT FOR IMPROVING HAIR OR SCALP CONDITION

Non-Final OA §102§112
Filed
Dec 29, 2023
Examiner
CHEN, PO-CHIH
Art Unit
1621
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Cosmax Bio Co. Ltd.
OA Round
1 (Non-Final)
75%
Grant Probability
Favorable
1-2
OA Rounds
2y 7m
To Grant
88%
With Interview

Examiner Intelligence

Grants 75% — above average
75%
Career Allow Rate
553 granted / 740 resolved
+14.7% vs TC avg
Moderate +14% lift
Without
With
+13.8%
Interview Lift
resolved cases with interview
Typical timeline
2y 7m
Avg Prosecution
52 currently pending
Career history
792
Total Applications
across all art units

Statute-Specific Performance

§101
0.4%
-39.6% vs TC avg
§103
27.5%
-12.5% vs TC avg
§102
20.0%
-20.0% vs TC avg
§112
31.8%
-8.2% vs TC avg
Black line = Tech Center average estimate • Based on career data from 740 resolved cases

Office Action

§102 §112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAIL ACTION This office action is a response to a 371 application filed -----12/29/2023, which is a national stage application of PCT/KR2022/009464 filed 6/30/2022, which claims foreign priority to KR10-2021-0085806 filed 6/30/2021. As filed, claims 1-6 are pending, wherein claim 1 is an independent claim; and claims 7-13 are cancelled. Information Disclosure Statement The information disclosure statement (IDS) submitted on 12/29/2023 has been considered by the Examiner. Priority Receipt is acknowledged of certified copies of papers required by 37 CFR 1.55. Claim Rejections - 35 USC § 112(b) The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 6 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Regarding claim 6, the claim is dependent of claim 1, and claim 6 recites the phrase, “the health functional food” wherein the word, “the”, requires antecedent basis, and it is unclear where applicant has defined “a” health functional food in claim 1 or 6. Without antecedent basis, the claim is rendered indefinite. Claim Rejections - 35 USC § 112 fourth paragraph The following is a quotation of the fourth paragraph of 35 U.S.C. § 112: Subject to the following paragraph [concerning multiple dependent claims], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers (emphasis added). Claims 3 and 6 are rejected under the fourth paragraph of 35 U.S.C. § 112 and under 37 CFR § 1.75(c), as being of improper dependent form for failing to further limit the subject matter of a previous claim. Applicant is required to cancel the claim(s), or amend the claim(s) to place the claim(s) in proper dependent form, or rewrite the claim(s) in independent form. Regarding claim 3, the claim is dependent upon claim 1. The subject matter in claim 1 is drawn to a method of preventing, alleviating, or treating hair loss via hydrangenol of instant formula (1). The subject matter in claim 3 is drawn to a limited embodiment of the method. The scope of claim 3 is broader than scope of claim 1 because claim 3 includes species that are outside of the hair or scalp condition depicted in claim 1 (e.g. hair damage, etc. vs. hair loss). Because the scope of claim 3 is broader than claim 1, the claim failed to further limit the subject matter thereof, and fail to comply with the formal requirements set forth in the fourth paragraph of 35 U.S.C § 112. The Examiner suggests that the claims be amended in a manner such that the scope of claim 3 is commensurate with the scope of claim 1. Regarding claim 6, the claim is dependent upon claim 1. The subject matter in claim 1 is drawn to a method of preventing, alleviating, or treating hair loss via hydrangenol of instant formula (1). The subject matter in claim 6 is drawn to a limited embodiment of the method. The scope of claim 6 is broader than scope of claim 1 because claim 6 includes species that are outside of the hydrangenol of instant formula (1) (e.g. the health functional food, etc.). Because the scope of claim 6 is broader than claim 1, the claim failed to further limit the subject matter thereof, and fail to comply with the formal requirements set forth in the fourth paragraph of 35 U.S.C § 112. The Examiner suggests that the claims be amended in a manner such that the scope of claim 6 is commensurate with the scope of claim 1. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Foreign Patent No. KR10-2016-0081204 (see IDS filed 12/29/2023) and its machine-generated English translation, hereinafter Suk, as evidenced by “Chemical Constituents from leaves of Hydrangea serrata and Their Anti-photoaging Effects on UVB-Irradiated Human Fibroblast”, hereinafter Shin. Regarding claims 1-6, Suk, for instance, teaches a composition comprising an extract of Hydrangea Serrata as an active ingredient in a solid dosage form (e.g. tablets, pills, etc.) for preventing hair loss and promoting hair growth. The extract has shown to promote proliferation of dermal papilla cells. PNG media_image1.png 100 728 media_image1.png Greyscale (paragraph 0011 of the English translation) PNG media_image2.png 220 742 media_image2.png Greyscale (paragraph 0010 of the English translation) PNG media_image3.png 128 714 media_image3.png Greyscale (paragraph 0091 of the English translation) PNG media_image4.png 328 720 media_image4.png Greyscale (paragraph 0040 of the English translation) Although Suk did not explicitly teach hydrangenol for preventing hair loss and promoting hair growth, the Examiner finds that hydrangenol is identified as the main ingredient out of ten compounds isolated from Hydrangea Serrata extract, according to evidentiary reference Shin. Therefore, the Examiner finds that a person of ordinary skill in the art would read the abovementioned Suk and Shin publications and “at once envisage” that hydrangenol is present in the Hydrangea Serrata extract of Suk, thereby inherently preventing hair loss and promoting hair growth via promoting proliferation of dermal papilla cells. PNG media_image5.png 202 774 media_image5.png Greyscale (pg. 426, right column, PNG media_image6.png 240 252 media_image6.png Greyscale (pg. 426, Fig. 1) Although Suk, as evidenced by Shin, did not explicitly teach that hydrangenol inhibits 5α-reductase, increases the tensile strength of hair or alleviates roughness of hair cuticles, the Examiner finds that the abovementioned therapeutic activities are inherent features of hydrangenol as taught by Suk, as evidenced by Shin. According to MPEP 21121(I) and (II), the discovery of a previously unappreciated feature of hydrangenol, as taught by Suk and Shin, does not render the abovementioned therapeutic activities patentable to the Applicant. In addition, such inherent therapeutic activities did not have to recognized at the time of invention by Suk and Shin. All of which led to the abovementioned anticipation. Claim Objections Claims 2-5 are objected to because of the following informalities: Regarding claim 2, the claim recites the phrase, “wherein the hydrangenol is isolated”. Such expression can be clarified by reciting -- wherein the hydrangenol represented by Formula 1 is isolated --. Regarding claim 3, the claim recites the phrase, “wherein improving the hair or scalp condition includes: preventing or alleviating hair damage; promoting hair growth; or inhibiting, preventing, or alleviating hair loss”, which contains typographical error. Such typographical error can be corrected by reciting -- wherein the hydrangenol represented by Formula 1 prevents or alleviates hair damageor promotes hair growth Regarding claim 4, the claim recites the phrase, “wherein the hydrangenol inhibits 5α-reductase”. Such expression can be clarified by reciting -- wherein the hydrangenol represented by Formula 1 inhibits 5α-reductase --. Regarding claim 5, the claim recites the phrase, “wherein the hydrangenol increases the tensile strength of the hair and”. Such expression can be clarified by reciting -- wherein the hydrangenol represented by Formula 1 increases --. Appropriate correction is required. Conclusion Claims 1-6 are rejected. Claims 2-5 are objected. Claims 7-13 are cancelled. Telephone Inquiry Any inquiry concerning this communication or earlier communications from the examiner should be directed to PO-CHIH CHEN whose telephone number is (571)270-7243. The examiner can normally be reached Monday - Friday 10:00 am to 6:00 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Clinton Brooks can be reached at (571)270-7682. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /PO-CHIH CHEN/Primary Examiner, Art Unit 1621
Read full office action

Prosecution Timeline

Dec 29, 2023
Application Filed
Feb 21, 2026
Non-Final Rejection — §102, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
75%
Grant Probability
88%
With Interview (+13.8%)
2y 7m
Median Time to Grant
Low
PTA Risk
Based on 740 resolved cases by this examiner. Grant probability derived from career allow rate.

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