Prosecution Insights
Last updated: October 25, 2026
Application No. 18/581,289

PRECURSOR COMPOUNDS FOR PROVIDING RETINOIDS OF THE VATAMIN A5 PATHWAY AND USES THEREOF

Final Rejection §112§DOUBLEPATENT
Filed
Feb 19, 2024
Priority
Nov 17, 2016 — HU P1600629 +3 more
Examiner
YOO, SUN JAE
Art Unit
1621
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
UNIVERSITE DE STRASBOURG
OA Round
2 (Final)
71%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
72%
With Interview

Examiner Intelligence

Grants 71% — above average
71%
Career Allowance Rate
883 granted / 1241 resolved
+11.2% vs TC avg
Minimal +0% lift
Without
With
+0.3%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
95 currently pending
Career history
1320
Total Applications
across all art units

Statute-Specific Performance

§101
1.1%
-38.9% vs TC avg
§103
17.0%
-23.0% vs TC avg
§102
27.7%
-12.3% vs TC avg
§112
33.9%
-6.1% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1241 resolved cases

Office Action

§112 §DOUBLEPATENT
DETAILED ACTION Notice of Pre-AIA or AIA Status 1. The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Response to Amendment and Rebuttal Arguments 2. The amendment to the claims filed on August 7, 2026 have been fully considered. The amendments are sufficient to overcome the 35 USC 112b rejection of claim 10. 3. The amendments are not sufficient to overcome the 35 USC 112b rejection of claims 12 and 14. 4. The amendments to the claims and rebuttal arguments are not sufficient to overcome the obviousness-type double patenting rejection over US 12,029,715. Applicants rebuttal arguments have been considered, however, they are not found to be persuasive. Below are responses to the arguments. The claims were previously rejected as being unpatentable over claims of US 12,029,715. The claims of the patent are directed to methods for treatment of reducing the risk of a retinoid X receptor mediated signaling dysfunction (eg. vitamin A5 deficiency) comprising administering a compound of PNG media_image1.png 234 300 media_image1.png Greyscale with specific embodiments that are the present elected species. It was determined that the claims of the patent suggest to the skilled artisan to practice the present invention, and that the present claims are prima facie obvious. Applicants argue that the rejection does not identify particular claims as compared with the present claims. Moreover, Applicants argue that the rejection does not identify the difference and why that difference would have been obvious. These arguments have been considered, however, they are not found to be persuasive. The rejection does set forth and explain the content of claims 1-17 of the patent and how they make obvious claims 10-12 and 14-17 of the present application. See above. For this reason, it is maintained that the rejection is proper. Claims 10-12 and 14-17 remain rejected. Conclusion THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to SUN JAE YOO whose telephone number is (571)272-9074. The examiner can normally be reached Mon-Fri 8-5. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /SUN JAE YOO/Primary Examiner, Art Unit 1621
Read full office action

Prosecution Timeline

Feb 19, 2024
Application Filed
Aug 18, 2025
Response Filed
Jan 21, 2026
Applicant Interview (Telephonic)
Jan 21, 2026
Examiner Interview Summary
Jan 24, 2026
Response Filed
Apr 07, 2026
Non-Final Rejection mailed — §112, §DOUBLEPATENT
Aug 07, 2026
Response Filed
Oct 14, 2026
Final Rejection mailed — §112, §DOUBLEPATENT (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
71%
Grant Probability
72%
With Interview (+0.3%)
2y 8m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1241 resolved cases by this examiner. Grant probability derived from career allowance rate.

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