Prosecution Insights
Last updated: October 04, 2026
Application No. 18/587,826

NOVEL CATIONIC POLYPHOSPHAZENE COMPOUND, POLYPHOSPHAZENES-DRUG CONJUGATE COMPOUND AND METHOD FOR PREPARING SAME

Non-Final OA §112
Filed
Feb 26, 2024
Priority
Mar 14, 2014 — RE 10-2014-0030564 +6 more
Examiner
KAUCHER, MARK S
Art Unit
1764
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Cnpharm Co. Ltd.
OA Round
2 (Non-Final)
72%
Grant Probability
Favorable
2-3
OA Rounds
2m
Est. Remaining
86%
With Interview

Examiner Intelligence

Grants 72% — above average
72%
Career Allowance Rate
730 granted / 1008 resolved
+7.4% vs TC avg
Moderate +14% lift
Without
With
+14.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 9m
Avg Prosecution
28 currently pending
Career history
1024
Total Applications
across all art units

Statute-Specific Performance

§101
0.9%
-39.1% vs TC avg
§103
42.9%
+2.9% vs TC avg
§102
23.4%
-16.6% vs TC avg
§112
20.3%
-19.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1008 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Continued Examination Under 37 CFR 1.114 A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on 2 /12/26 has been entered. Priority The petition under 37 1.55(e) has been granted. See Petition decision filed 5/29/26. Acknowledgment is made of applicant’s claim for foreign priority under 35 U.S.C. 119 (a)-(d). The certified copy has been filed in parent Application No. 15/125,543, filed on 9/12/16. Claim Objections Claims 1, 6, 10 and 12 are objected to because of the following informalities: In the seventh to last line of claim 1, tyrosinecontaining should be “tyrosine-containing”. In claims 6 and 10, the tildes (“~”) should be normal scripted not superscripted. Appropriate correction is required. Claim 12 is objected to because it does not end in a period. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 8 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 8 states that the spacer selected from “lysine ester, lysine-containing oligopeptide ester, amino-ethanol, …”, however the claimed structures can only be obtained by either a lysine ester or a lysine containing oligopeptide ester, therefore it is unclear how the claimed structures can be formed by e.g. amino-ethanol. Is the claim attempted to claim a mixture of compounds in addition to the claimed compounds (e.g. compounds with an amino-ethanol linker)? Further the way the claim is written raises questions as to if a mixture of polymers or a single polymer is being claimed. The claim states that the reaction yields “formula 19 and 20”, which suggests both are present. However, the claim also states that the spacer is selected from the group suggesting that the reaction yields formula 19 or 20. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to MARK S KAUCHER whose telephone number is (571)270-7340. The examiner can normally be reached M-F 8-6 PM EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Arrie Lanee Reuther can be reached at (571) 270-7026. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /MARK S KAUCHER/Primary Examiner, Art Unit 1764
Read full office action

Prosecution Timeline

Feb 26, 2024
Application Filed
Apr 11, 2025
Non-Final Rejection mailed — §112
Oct 14, 2025
Response Filed
Dec 08, 2025
Examiner Interview (Telephonic)
Dec 08, 2025
Examiner Interview Summary
Feb 12, 2026
Request for Continued Examination
Feb 15, 2026
Response after Non-Final Action
Aug 21, 2026
Non-Final Rejection mailed — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

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Patent 12741936
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2y 10m to grant Granted Sep 22, 2026
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Patent 12729293
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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
72%
Grant Probability
86%
With Interview (+14.0%)
2y 9m (~2m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1008 resolved cases by this examiner. Grant probability derived from career allowance rate.

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