Last updated: July 17, 2026

Application No. 18/609,758

TIE2-BINDING AGENTS AND METHODS OF USE

Non-Final OA

Filed

Mar 19, 2024

Priority

Mar 24, 2020 — provisional 62/993,930 +2 more

Examiner

ALLEN, MARIANNE P

Art Unit

1647

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

Genentech Inc.

OA Round

1 (Non-Final)

This examiner grants 60% of cases after interview

— +18.2% interview lift. A telephonic interview to clarify the technical implementation could significantly improve the outcome.

Based on 996 resolved cases, 2023–2026

Examiner Intelligence

ALLEN, MARIANNE P View full profile →

Grants 60% of resolved cases

Career Allowance Rate

599 granted / 996 resolved

At TC average

Strong +18% interview lift

Without

With

+18.2%

Interview Lift

resolved cases with interview

Typical timeline

2y 10m

Avg Prosecution

43 currently pending

Career history

1045

Total Applications

across all art units

Statute-Specific Performance

§101

0.4%

-39.6% vs TC avg

§103

32.0%

-8.0% vs TC avg

§102

15.8%

-24.2% vs TC avg

§112

42.9%

+2.9% vs TC avg

Black line = Tech Center average estimate • Based on career data from 996 resolved cases

Prosecution Timeline

Mar 19, 2024

Application Filed

May 13, 2025

Response after Non-Final Action

Dec 10, 2025

Response after Non-Final Action

May 12, 2026

Non-Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

17/997,582

Patent 12679884

RED LIGHT-CONTROLLED PROTEIN DIMERIZATION SYSTEMS

3y 8m to grant Granted Jul 14, 2026

17/408,893

Patent 12662525

TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS

4y 10m to grant Granted Jun 23, 2026

17/727,120

Patent 12653863

FGF21 COMPOSITIONS FOR TREATMENT OR PREVENTION OF NEOVASCULARIZATION OF THE EYE AND METHODS THEREFOR

4y 1m to grant Granted Jun 16, 2026

14/128,681

Patent 12630609

TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS

12y 2m to grant Granted May 19, 2026

17/453,981

Patent 12617848

METHODS OF TREATING OCULAR PATHOLOGIES USING BIFUNCTIONAL MOLECULES THAT TARGET GROWTH FACTORS

4y 5m to grant Granted May 05, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2

Expected OA Rounds

60%

Grant Probability

78%

With Interview (+18.2%)

2y 10m (~6m remaining)

Median Time to Grant

Low

PTA Risk

Based on 996 resolved cases by this examiner. Grant probability derived from career allowance rate.