DETAILED ACTION
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
Election/Restrictions
Claims 1, 5-8, 10, 12-18, 22, 24, 26-30, 35 are pending and cl. 36 and 37 are new.
Claim 14 is withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected species, there being no allowable generic or linking claim. Election was made without traverse in the reply filed on 09/19/2024.
Claims 1, 5-8, 10, 12-13, 15-18, 22, 24, 26-30, 35-37 along with the elected species of DOTAP (cl. 10), squalene (cl. 13), metal oxide and iron oxide (cl. 17, 18, respectively) and surfactant (cl. 27) and enterovirus (cl. 1) are examined here.
Priority
The claim to provisional application 63/246978, filed on 09/22/2021, via its CON of PCT/US2022/076787, with the filing date of 09/21/2022, is recognized. All examined claims enjoy the benefit of ‘978 filing date.
Information Disclosure Statement
The information disclosure statement (IDS) submitted on 6/22/2026 and its fee is filed after the mailing date of the first Office Action.
Some NPLs of the information disclosure statement filed 06/22/2026 fail to comply with the provisions of 37 CFR 1.97, 1.98 and MPEP § 609 because cite #s 3 and 5 fail to indicate the number of pages or relevant pages, e.g., Heuts is 19 pages, thus either 19 pages or 1-19 pg. needs to be noted in the IDS. Those cites have a strike-out line across them. It has been placed in the application file, but the information of crossed-off cites referred to therein has not been considered as to the merits. For Cite #4, only the English abstract is considered for the foreign language NPL. Applicant is advised that the date of any re-submission of any item of information contained in this information disclosure statement or the submission of any missing element(s) will be the date of submission for purposes of determining compliance with the requirements based on the time of filing the statement, including all certification requirements for statements under 37 CFR 1.97(e). See MPEP § 609.05(a).
Claim Interpretation
Claim 1 recites “wherein the RNA comprises a sequence that has at least 80% sequence identity to SEQ ID NO: 18.” The claim limitation is interpreted as “wherein the RNA comprises a sequence that has at least 80% sequence to the SEQ ID NO: 18,” and is interpreted as RNA having at least 80% sequence identity to the full sequence of SEQ ID NO: 18.
35 U.S.C. 112(b):
Rejection of cl. 21 and 23 is withdrawn, the claims are canceled.
35 U.S.C. 112(d)
Rejection of cl. 21, 23 and 25 is withdrawn, the claims are canceled.
Claim Rejections - 35 USC § 103
The rejection of claims 1, 5-8, 10, 12-13, 15-18, 22, 24, 26-30, 35 under 103 in view of Erasmus and Yan and other cited references is withdrawn due to claim amendments. However, upon further search and consideration the examined claims are rejected as noted below.
In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status.
The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action:
A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made.
The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows:
1. Determining the scope and contents of the prior art.
2. Ascertaining the differences between the prior art and the claims at issue.
3. Resolving the level of ordinary skill in the pertinent art.
4. Considering objective evidence present in the application indicating obviousness or nonobviousness.
This application currently names joint inventors. In considering patentability of the claims the examiner presumes that the subject matter of the various claims was commonly owned as of the effective filing date of the claimed invention(s) absent any evidence to the contrary. Applicant is advised of the obligation under 37 CFR 1.56 to point out the inventor and effective filing dates of each claim that was not commonly owned as of the effective filing date of the later invention in order for the examiner to consider the applicability of 35 U.S.C. 102(b)(2)(C) for any potential 35 U.S.C. 102(a)(2) prior art against the later invention.
Claims 1, 5-8, 10, 12-13, 15-18, 22, 24, 35-36 are rejected under 35 U.S.C. 103 as being unpatentable over Erasmus et al. (8/2020, Science Translation Med., 12, pg. 1-11, referred as Erasmus, shares co-inventors but outside of one yr. grace period, of record) and further in view of Zhang et al. (2018, Emerging Microbes and Infection, 7, pg. 1-9, referred as Zhang) and Yan et al. (2016, Vaccine, 34, 4196-4204, referred as Yan), as evidenced by sequence of EV-D68 strain (2014, GenBank®: KM851225.1, ncbi.nlm.nih.gov/nuccore/KM851225, accessed 03/05/25) and as evidenced by for cl. 1.
Regarding instant cl. 1, Erasmus discloses a virus-derived replicon RNA (repRNA of alphavirus, VEEV) vaccine for delivery of virus-like RNA particles incorporated with a lipid inorganic nanoparticle (LION) (pg. 1); discloses an ORF encoding a viral RNA-dependent RNA polymerase (see Fig. 1A, nsp4 is RdRp, relevant to instant cl. 1i), but with the structural protein genes replaced with an antigen-encoding gene (see Fig. 1A, pg. 1-2); demonstrated use of SARS-Covid-2 S protein(CoV2S) encoding sequence as an antigen-encoding gene (pg. 1-2); discloses LION, a highly stable cationic squalene emulsion with superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIO) embedded in squalene, a hydrophobic oil phase (pg. 2, see Fig. 1).
Fig. 1D of Erasmus
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Erasmus discloses a cationic lipid, DOTAP in figure above; discloses the hydrophobic core, a squalene oil phase; discloses Span60 (a sorbitan monostearate, a hydrophobic surfactant) and Tween 80 (a polysorbate, a hydrophilic surfactant) (pg. 7, relevant to instant cl. 1). The LION is designed to enhance vaccine stability (can be stored at room temperature for 7 days and withstands RNAse exposure, see Fig. 1) and for intracellular delivery (pg. 2). Erasmus discloses a key component of LION is the cationic lipid 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), which enables electrostatic association with RNA molecules on LION’s surface (pg. 3, see fig. above, relevant to instant cl. 1). Erasmus discloses dsDNA plasmid vector with sequence of nonstructural ORF of VEEV strain TC-83 with sequence encoding SARS-CoV-2-antigen ligated in the vector (pg. 6) and the vector was linearized and transcribed to produce RNA molecule (relevant to instant cl. 1).
Erasmus does not disclose a nucleic acid sequence encoding a D68 enterovirus structural protein and an enterovirus D68 3CD protease, wherein the virus structural protein is a substrate for the virus protease.
Zhang discloses a plasmid expression cassette expressing both 3CD and P1 of enterovirus-D68 strain (EV-D68, virus belonging to Picornaviridae family, pg. 1) used to transform a yeast strain to express 3CD protease protein and P1 polypeptide, which comprises three capsid subunit proteins (VP0, VP1, and VP3) of EV-D68 that co-assemble following cleavage by 3CD protease to form viral capsid shells (pg. 4, 1, relevant to instant cl. 1ii, 1iii). Zhang discloses production of neutralizing antibodies against the VP0, VP1 and VP3 antigens that protects mice against lethal EV-D68 infection (pg. 5, Fig. 3). Zhang discloses that the EV-D68 strain is associated with severe respiratory illness and neurological complications in children (abstract); and once a rare infection in US, in 2014, there were 1153 confirmed cases with 14 deaths, making it the largest and most widespread of EV-D68 outbreaks recorded in the world (pg. 2). Zhang discloses an EV-D68 strain US/MO/14-18947, with GenBank® ID: KM851225. Alignment of instant SEQ ID NO: 18 and sequence of EV-D68 strain (2014, GenBank®: KM851225.1, www.ncbi.nlm.nih.gov/nuccore/KM851225) is noted below (relevant to instant cl. 35). Further, Zhang demonstrates that passive transfer of anti-VLP sera protected all suckling mice against lethal infection while ones treated with control sera all died (pg. 6, Fig. 5, pg. 7).
Further, although Zhang discloses vector with P1, 3CD alone, and one with P1 and 3CD, it does not clearly demonstrate the vector with P1 and 3CD has improved activity/expression compared to P1 and 3CD alone, however Yan discloses that immunization with delivery vector comprising 3CD and P1 sequence of enterovirus results in improved survival as opposed to 3CD or P1 alone (pg. 4201, Fig. 6E).
Both Zhang and Yan disclose ability to insert any enteroviruses strain’s nucleic acid sequence encoding structural protein and its protease into a vector that is administered in vivo to produce an effective immune response against the expressed structural protein of enterovirus.
Zhang’s EV-D68 genomic sequence is not at least 80% identical (cl. 1(iii)) nor 100% identical (cl. 35) to instant SEQ ID NO: 18. Instant Fig. 12A illustrates a schematic of SEQ ID NO: 18, which at least comprises SEQ ID NO: 8 from position 1 to 7561 (the nsPs of VEEV) and from position 7561 to 12956 comprises a sequence of D68 structural protein P1 and 3CD protease with an IRES sequence in between (see schematic below).
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However Zhang’s EV-D68 sequence encodes D68 structural protein and 3CD protease (see pg. 2 of NCBI page, pos. 697-3279 encodes VP1-VP4, and pos. 5341-7260 encodes 3C-3D). Aligning just the structural proteins P1 and 3CD of instant SEQ ID NO: 18, based on Expasy®-based translation, and of Zhang’s EV-D68 (it’s translation product is noted on NCBI page 1-2), there is a 100% match between the proteins coded (see alignment below, except for the difference of starting methionine for SEQ ID NO: 18 3CD protease). Thus, instant SEQ ID NO: 18 substitutes the codon of Zhang’s EV-D68, thus varying the nucleotide sequences for the encoded protein, but the nucleotide sequences still encode the same proteins as Zhang’s EV-D68 structural protein and protease. Thus, insertion of instant 3CD and structural sequences would produce similar antigenic activity and/or titers as thought of Zhang’s, see Fig. 3C; thus instant claimed invention would not be patentably distinct even though the sequence are not 80% nor 100% identical or the claimed invention is an obvious variant of Zhang’s structural and protease proteins.
One of the KSR’s rationale for supporting conclusion of obviousness is “obvious to try,” requiring the following three findings: (1) a finding that at the relevant time, there had been a recognized problem or need in the art, which may include a design need or market pressure to solve a problem; (2) a finding that there had been a finite number of identified, predictable potential solutions to the recognized need or problem; (3) a finding that one of ordinary skill in the art could have pursued the known potential solutions with a reasonable expectation of success.
Zhang discloses the problem of lethality of EV-D68 and discloses a methodology to produce an antigenic vector to produce neutralization antibodies against a EV-D68 strain.
Therefore, It would have been obvious for one of ordinary skill in the art before the effective filing date of the claimed invention to have try to modify the VEEV plasmid vector in the LION/vector composition of Erasmus by incorporating a nucleotide sequences that encodes P1 structural protein antigen and 3CD protease from an EV-D68 genome as taught by Zhang and Yan to produce the LION/vector containing antigen nucleotide sequence of Erasmus. Because Erasmus teaches a very stable and effective vaccine composition comprising a VEEV plasmid vector in the LION/vector composition that can be maintained at room temperature, and Zhang demonstrates that immunization with delivery vector comprising 3CD and P1 sequences of EV-D68 results in improved survival of EV infected mice, and Yan demonstrates that both a vaccine vector with both 3CD and P1 of enterovirus is more effective than 3CD or P1 alone, a skilled artisan would reasonably expect success by trying a nucleotide sequence of any EV-D68 strain, i.e. such as that encodes for P1 structural protein and 3CD protease by GenBank® KX789234 nucleotide sequence, as taught by Zhang and incorporating the nucleotide sequences for the RNA antigen of the VEEV RNA construct incorporated within a LION particle of Erasmus for a stable vaccine that can be stored at room temperature for a reasonable duration and be used for immunization against debilitating EV-D68 virus. Thus, cl. 1 is obvious.
Regarding claim 5-7, Erasmus discloses LION has an intensity-weighted average diameter of 52 nm (pg. 3).
Regarding instant cl. 8, 10, Erasmus discloses the oil and aqueous phases were mixed and emulsified using a homogenizer, and a key component of LION is the cationic lipid 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), which enables electrostatic association with RNA molecules when combined by a simple 1:1 (v/v) mixing step (Fig. 1D, pg. 2, see figure above).
Regarding instant cl. 12, 13, as noted above, Erasmus discloses that hydrophobic core comprises the oil squalene (see fig. above, pg. 2).
Regarding instant cl. 15-18, the figure above of Erasmus illustrates inorganic iron oxide particles within the hydrophobic squalene (pg. 2).
Regarding instant cl. 22, 24, LION is comprised of squalene oil, Span60 (a sorbitan monostearate) (relevant to instant cl. 22) and Tween 80 (a polysorbate) (relevant to instant cl. 24).
Regarding instant cl. 36, Erasmus discloses alphavirus as Venezuelan equine encephalitis virus, strain T-83 (pg. 2, Fig. 1 legend).
Claim 37 is rejected under 35 U.S.C. 103 as being unpatentable over Erasmus et al. (8/2020, Science Translation Med., 12, pg. 1-11, referred as Erasmus, in IDS) and Zhang et al. (2018, Emerging Microbes and Infection, 7, pg. 1-9) as applied to claims 1, 5-8, 10, 12-13, 15-18, 22-25 above, and further, as evidenced by sequence of VEEV, strain TC-83 of GenBank® L01443.1 (2004, ncbi.nlm.nih.gov/nuccore/323714, accessed 3/5/2025, of record).
Erasmus discloses a plasmid vector comprising nonstructural ORF of VEEV, as evidenced by sequence of VEEV, strain TC-83 of GenBank® L01443.1, and has ~99.9% identity to instant SEQ ID NO: 8, see action of 03/20/2025, pg. 13 for rej. of prior cl. 34, and see alignment on pg. 18-24. The 4 nt. is a different codon usage within the nsP1 peptide, however the encoded NSP-1 peptide is the same. Therefore a skilled artisan would reasonably expect success by trying to utilize different codons to express the same VEEV nsP1 protein.
Claims 26-30 are rejected under 35 U.S.C. 103 as being unpatentable over Erasmus et al. (8/2020, Science Translation Med., 12, pg. 1-11, referred as Erasmus, in IDS) and Zhang et al. (2018, Emerging Microbes and Infection, 7, pg. 1-9) as applied to claims 1, 5-8, 10, 12-13, 15-18, 22, 24, 35-36 above, and further in view of Vargas et al. (2019, J. of Materials Chem., 7, 695-708).
The disclosures of Erasmus and Zhang are noted above. It should be noted that Erasmus teaches iron oxide nanoparticle embedded in the hydrophobic oil phase (pg. 2, relevant to cl. 26 limitation “wherein the hydrophobic core further comprises one or more inorganic particles”).
Erasmus and Zhang do not disclose composition with a phosphate-terminated lipid of instant claims 26-30, or recited surfactant of instant claims 29-30.
Vargas discloses various hybrid lipid nanoparticles (HLNPs) for biomedical applications, and notes various inorganic particles that can be associated with the nanoparticle, gold, silver, palladium; and iron oxide; and each has a benefit, for e.g. iron oxide, forming a super paramagnetic iron oxide particles (SPIONs) for magnetic field-guided drug delivery system (pg. 695-696, relevant to instant cl. 26); further discloses that the nanoparticles can be categorized into five types based on the localization of the nanoparticles within the lipid assembly, one being liposomes with surface bound nanoparticles or liposomes with core-encapsulated nanoparticles (pg. 696, relevant to cl. 26); discloses the use of surfactants, such as phospholipids, to stabilize the solid lipid core (pg. 702, relevant to cl. 29); discloses the use of TOPO ligands on CdSe/ZnS quantum dots for improved fluorescent imaging in cells (pg. 702, relevant to instant claims 26, 27 and 28); discloses oleic acid capped maghemite SPIONs embedded in DPPC liposomes for release of AMF-triggered release of fluorescent dyes (pg. 700, relevant to instant cl. 30).
One of the KSR rationale that may be used to support a conclusion of obviousness is that there is some teaching, suggestion, or motivation in the prior art that would have led one of ordinary skill to modify the prior art reference or to combine prior art reference teachings to arrive at the claimed invention. Therefore, It would have been prima facie obvious for one of ordinary skill in the art before the effective filing date of the claimed invention to have modified the nanoparticles containing heterologous construct of repRNA/LION particle and enterovirus capsid/protease sequence of Erasmus and Zhang in view of Vargas and arrive at the claimed invention with a reasonable expectation of success. Because Erasmus teaches a very stable and effective vaccine composition comprising a VEEV plasmid vector in the LION/vector composition that can be maintained at room temperature, and Zhang demonstrates that immunization with delivery vector comprising 3CD and P1 sequences of EV-D68 results in improved survival, and Vargas teaching of using phospholipids for improved stabilization, and use of TOPO ligands with inorganic particles for improved imaging, a skilled artisan would reasonably expect success by modifying the repRNA/LION composition of Erasmus with addition of phospholipids for improved nanoparticle stability and addition of TOPO with disclosed inorganic particles and/or oleic acid surfactant for improved imaging as disclosed by Vargas. Thus, cl. 26-30 are obvious.
Response to Arguments
Due to the claim amendments the rejection of examined claims is withdrawn. However, upon further consideration, a new ground(s) of rejection is made, see above.
The Remarks of 6/22/2026 argue the following:
The Remarks argue that no reasonable expectation of success is established (pg. 8), and notes the methodology of Yan using DNA plasmids and thus “to arrive at the RNA structural arrangements recited in amended claim 1, one of skill in the art would be left exploring countless strains and clades of enterovirus” (pg. 9).
The Remarks argue, concerning rejection of cl. 33 and 35, that Zhang does not cure deficiencies of Erasmus or Yan, since the sequence of strain of EV-D68 (KM851225) does not match the claimed sequence identity (pg. 11-12).
Further, the Remarks indicate unexpected results: first the Remarks notes isolation of a specific clade’s VP1 and protease variant sequence and indicate that non-human primate immunization “produced 50% neutralization titers within 7 days” and this was not the case for the RNA constructs that did not have the same RNA structure, citing specification par. 172-173 and Fig. 13-14. Fig. 14 compares EVD68repRNA with CCHFV repRNA (Crimean-Congo Hemorrhagic Fever Virus”.
The arguments are not persuasive.
Here the action provides sufficient rationale for a reasonable expectation of success. Zhang provides the methodology that regardless of strain that it would be obvious to try by a skilled artisan to isolate the structural protein and protease sequence of any enterovirus, as taught by Zhang, and reasonably expect success in designing a LION/vector with antigenic sequence based on cited references. Here, because there are numerous numbers of antigens possible, a skilled artisan would reasonably expect success in producing vector expressing antigen as a vaccine.
It is understood that viruses undergo mutations due to evolution and the expression of some mutations are beneficial while other aren’t under principles of Mendelian genetics. Patel et al. (2016, PLoS One, 11, e0166336, pg. 1-22) discloses categorizing different EV-D68 strains into various clades (A, B, and C) due to point mutations arising within a strain, and then generated EV-D68 vaccines based on different EV-D68 strains (see Fig. 1A for evolutionary tree showing three major clades of EV-D68, pg. 4.; and intramuscular immunization with EV-D68 strains, pg. 7). Thus it is not novel to categorizing strains into clades and see their effects on generating vaccines. Further, Zhang’s cross-neutralization study notes that EV-D68 antisera strongly neutralized one heterologous strain (US/KV/14-18953) but not to other enteroviruses (EV-A71/G082, CV-A16/SZ05), pg. 5. Thus, variance in strains is known. However, the Remarks do not provide clear rationale why the different VP1 amino acid sequence, i.e. claimed invention, will result in improved antigenic activity and is not obvious over the VP1 antigenic sequence of Zhang. Further, Expasy based translation of the structural protein P1 and 3CD of instant SEQ ID NO: 18 and its alignment with Zhang’s strains resulted in 100% identity between the structural P1 and the protease 3CD proteins.
Regarding the unexpected results, first, the results noted are not commensurate with claimed invention. Here, the results do not compare between different species of the genus of at least 80% of the SEQ ID NO: 18. The results are of 100% identity of SEQ ID NO: 18. Second, the claimed invention is to any alphavirus RdRp but the results uses a specific VEEV RdRp (see Ex. 2, pg. 62-63: the “VEEV replicon mRNA backbone is set forth in SEQ ID NO: 8”). Third, the results do not provide comparison to a EV-D68 strain to demonstrate that the instant claimed D68 based on differential analysis of amino acid sequence is unexpected to other EV-D68 strains. The results compare it to another virus entirely (CCHFV), which is not even in Picornavirus family.
Thus, the examined claims are rejected.
Conclusion
Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a).
A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action.
Any inquiry concerning this communication or earlier communications from the examiner should be directed to KEYUR A. VYAS whose telephone number is (571)272-0924. The examiner can normally be reached M-F 9am - 4 pm (EST).
Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice.
If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Jennifer Dunston can be reached on 571-272-2916. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300.
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/KEYUR A VYAS/Examiner, Art Unit 1637
/Jennifer Dunston/Supervisory Patent Examiner, Art Unit 1637
Alignment between instant SEQ ID NO: 8 (Db) and VEEV GenBank® L01443.1 (Qy), relevant to instant cl. 37 .
Query Match 99.9%; Score 7553.6; DB 1; Length 7561;
Best Local Similarity 99.9%;
Matches 7556; Conservative 0; Mismatches 4; Indels 0; Gaps 0;
Qy 1 ATAGGCGGCGCATGAGAGAAGCCCAGACCAATTACCTACCCAAAATGGAGAAAGTTCACG 60
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1 ATAGGCGGCGCATGAGAGAAGCCCAGACCAATTACCTACCCAAAATGGAGAAAGTTCACG 60
Qy 61 TTGACATCGAGGAAGACAGCCCATTCCTCAGAGCTTTGCAGCGGAGCTTCCCGCAGTTTG 120
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 61 TTGACATCGAGGAAGACAGCCCATTCCTCAGAGCTTTGCAGCGGAGCTTCCCGCAGTTTG 120
Qy 121 AGGTAGAAGCCAAGCAGGTCACTGATAATGACCATGCTAATGCCAGAGCGTTTTCGCATC 180
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 121 AGGTAGAAGCCAAGCAGGTCACTGATAATGACCATGCTAATGCCAGAGCGTTTTCGCATC 180
Qy 181 TGGCTTCAAAACTGATCGAAACGGAGGTGGACCCATCCGACACGATCCTTGACATTGGAA 240
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 181 TGGCTTCAAAACTGATCGAAACGGAGGTGGACCCATCCGACACGATCCTTGACATTGGAA 240
Qy 241 GTGCGCCCGCCCGCAGAATGTATTCTAAGCACAAGTATCATTGTATCTGTCCGATGAGAT 300
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 241 GTGCGCCCGCCCGCAGAATGTATTCTAAGCACAAGTATCATTGTATCTGTCCGATGAGAT 300
Qy 301 GTGCGGAAGATCCGGACAGATTGTATAAGTATGCAACTAAGCTGAAGAAAAACTGTAAGG 360
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 301 GTGCGGAAGATCCGGACAGATTGTATAAGTATGCAACTAAGCTGAAGAAAAACTGTAAGG 360
Qy 361 AAATAACTGATAAGGAATTGGACAAGAAAATGAAGGAGCTCGCCGCCGTCATGAGCGACC 420
|||||||||||||||||||||||||||||||||||||||| |||||||||||||||||||
Db 361 AAATAACTGATAAGGAATTGGACAAGAAAATGAAGGAGCTGGCCGCCGTCATGAGCGACC 420
Qy 421 CTGACCTGGAAACTGAGACTATGTGCCTCCACGACGACGAGTCGTGTCGCTACGAAGGGC 480
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 421 CTGACCTGGAAACTGAGACTATGTGCCTCCACGACGACGAGTCGTGTCGCTACGAAGGGC 480
Qy 481 AAGTCGCTGTTTACCAGGATGTATACGCGGTTGACGGACCGACAAGTCTCTATCACCAAG 540
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 481 AAGTCGCTGTTTACCAGGATGTATACGCGGTTGACGGACCGACAAGTCTCTATCACCAAG 540
Qy 541 CCAATAAGGGAGTTAGAGTCGCCTACTGGATAGGCTTTGACACCACCCCTTTTATGTTTA 600
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 541 CCAATAAGGGAGTTAGAGTCGCCTACTGGATAGGCTTTGACACCACCCCTTTTATGTTTA 600
Qy 601 AGAACTTGGCTGGAGCATATCCATCATACTCTACCAACTGGGCCGACGAAACCGTGTTAA 660
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 601 AGAACTTGGCTGGAGCATATCCATCATACTCTACCAACTGGGCCGACGAAACCGTGTTAA 660
Qy 661 CGGCTCGTAACATAGGCCTATGCAGCTCTGACGTTATGGAGCGGTCACGTAGAGGGATGT 720
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 661 CGGCTCGTAACATAGGCCTATGCAGCTCTGACGTTATGGAGCGGTCACGTAGAGGGATGT 720
Qy 721 CCATTCTTAGAAAGAAGTATTTGAAACCATCCAACAATGTTCTATTCTCTGTTGGCTCGA 780
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 721 CCATTCTTAGAAAGAAGTATTTGAAACCATCCAACAATGTTCTATTCTCTGTTGGCTCGA 780
Qy 781 CCATCTACCACGAGAAGAGGGACTTACTGAGGAGCTGGCACCTGCCGTCTGTATTTCACT 840
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 781 CCATCTACCACGAGAAGAGGGACTTACTGAGGAGCTGGCACCTGCCGTCTGTATTTCACT 840
Qy 841 TACGTGGCAAGCAAAATTACACATGTCGGTGTGAGACTATAGTTAGTTGCGACGGGTACG 900
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 841 TACGTGGCAAGCAAAATTACACATGTCGGTGTGAGACTATAGTTAGTTGCGACGGGTACG 900
Qy 901 TCGTTAAAAGAATAGCTATCAGTCCAGGCCTGTATGGGAAGCCTTCAGGCTATGCTGCTA 960
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 901 TCGTTAAAAGAATAGCTATCAGTCCAGGCCTGTATGGGAAGCCTTCAGGCTATGCTGCTA 960
Qy 961 CGATGCACCGCGAGGGATTCTTGTGCTGCAAAGTGACAGACACATTGAACGGGGAGAGGG 1020
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 961 CGATGCACCGCGAGGGATTCTTGTGCTGCAAAGTGACAGACACATTGAACGGGGAGAGGG 1020
Qy 1021 TCTCTTTTCCCGTGTGCACGTATGTGCCAGCTACATTGTGTGACCAAATGACTGGCATAC 1080
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1021 TCTCTTTTCCCGTGTGCACGTATGTGCCAGCTACATTGTGTGACCAAATGACTGGCATAC 1080
Qy 1081 TGGCAACAGATGTCAGTGCGGACGACGCGCAAAAACTGCTGGTTGGGCTCAACCAGCGTA 1140
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1081 TGGCAACAGATGTCAGTGCGGACGACGCGCAAAAACTGCTGGTTGGGCTCAACCAGCGTA 1140
Qy 1141 TAGTCGTCAACGGTCGCACCCAGAGAAACACCAATACCATGAAAAATTACCTTTTGCCCG 1200
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1141 TAGTCGTCAACGGTCGCACCCAGAGAAACACCAATACCATGAAAAATTACCTTTTGCCCG 1200
Qy 1201 TAGTGGCCCAGGCATTTGCTAGGTGGGCAAAGGAATATAAGGAAGATCAAGAAGATGAAA 1260
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1201 TAGTGGCCCAGGCATTTGCTAGGTGGGCAAAGGAATATAAGGAAGATCAAGAAGATGAAA 1260
Qy 1261 GGCCACTAGGACTACGAGATAGACAGTTAGTCATGGGGTGTTGTTGGGCTTTTAGAAGGC 1320
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1261 GGCCACTAGGACTACGAGATAGACAGTTAGTCATGGGGTGTTGTTGGGCTTTTAGAAGGC 1320
Qy 1321 ACAAGATAACATCTATTTATAAGCGCCCGGATACCCAAACCATCATCAAAGTGAACAGCG 1380
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1321 ACAAGATAACATCTATTTATAAGCGCCCGGATACCCAAACCATCATCAAAGTGAACAGCG 1380
Qy 1381 ATTTCCACTCATTCGTGCTGCCCAGGATAGGCAGTAACACATTGGAGATCGGGCTGAGAA 1440
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1381 ATTTCCACTCATTCGTGCTGCCCAGGATAGGCAGTAACACATTGGAGATCGGGCTGAGAA 1440
Qy 1441 CAAGAATCAGGAAAATGTTAGAGGAGCACAAGGAGCCGTCACCTCTCATTACCGCCGAGG 1500
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1441 CAAGAATCAGGAAAATGTTAGAGGAGCACAAGGAGCCGTCACCTCTCATTACCGCCGAGG 1500
Qy 1501 ACGTACAAGAAGCTAAGTGCGCAGCCGATGAGGCTAAGGAGGTGCGTGAAGCCGAGGAGT 1560
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1501 ACGTACAAGAAGCTAAGTGCGCAGCCGATGAGGCTAAGGAGGTGCGTGAAGCCGAGGAGT 1560
Qy 1561 TGCGCGCAGCTCTACCACCTTTGGCAGCTGATGTTGAGGAGCCCACTCTGGAAGCCGATG 1620
|||||||||||||||||||||||||||||||||||||||||||||||||||| || || |
Db 1561 TGCGCGCAGCTCTACCACCTTTGGCAGCTGATGTTGAGGAGCCCACTCTGGAGGCAGACG 1620
Qy 1621 TCGACTTGATGTTACAAGAGGCTGGGGCCGGCTCAGTGGAGACACCTCGTGGCTTGATAA 1680
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1621 TCGACTTGATGTTACAAGAGGCTGGGGCCGGCTCAGTGGAGACACCTCGTGGCTTGATAA 1680
Qy 1681 AGGTTACCAGCTACGATGGCGAGGACAAGATCGGCTCTTACGCTGTGCTTTCTCCGCAGG 1740
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1681 AGGTTACCAGCTACGATGGCGAGGACAAGATCGGCTCTTACGCTGTGCTTTCTCCGCAGG 1740
Qy 1741 CTGTACTCAAGAGTGAAAAATTATCTTGCATCCACCCTCTCGCTGAACAAGTCATAGTGA 1800
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1741 CTGTACTCAAGAGTGAAAAATTATCTTGCATCCACCCTCTCGCTGAACAAGTCATAGTGA 1800
Qy 1801 TAACACACTCTGGCCGAAAAGGGCGTTATGCCGTGGAACCATACCATGGTAAAGTAGTGG 1860
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1801 TAACACACTCTGGCCGAAAAGGGCGTTATGCCGTGGAACCATACCATGGTAAAGTAGTGG 1860
Qy 1861 TGCCAGAGGGACATGCAATACCCGTCCAGGACTTTCAAGCTCTGAGTGAAAGTGCCACCA 1920
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1861 TGCCAGAGGGACATGCAATACCCGTCCAGGACTTTCAAGCTCTGAGTGAAAGTGCCACCA 1920
Qy 1921 TTGTGTACAACGAACGTGAGTTCGTAAACAGGTACCTGCACCATATTGCCACACATGGAG 1980
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1921 TTGTGTACAACGAACGTGAGTTCGTAAACAGGTACCTGCACCATATTGCCACACATGGAG 1980
Qy 1981 GAGCGCTGAACACTGATGAAGAATATTACAAAACTGTCAAGCCCAGCGAGCACGACGGCG 2040
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1981 GAGCGCTGAACACTGATGAAGAATATTACAAAACTGTCAAGCCCAGCGAGCACGACGGCG 2040
Qy 2041 AATACCTGTACGACATCGACAGGAAACAGTGCGTCAAGAAAGAACTAGTCACTGGGCTAG 2100
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2041 AATACCTGTACGACATCGACAGGAAACAGTGCGTCAAGAAAGAACTAGTCACTGGGCTAG 2100
Qy 2101 GGCTCACAGGCGAGCTGGTGGATCCTCCCTTCCATGAATTCGCCTACGAGAGTCTGAGAA 2160
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2101 GGCTCACAGGCGAGCTGGTGGATCCTCCCTTCCATGAATTCGCCTACGAGAGTCTGAGAA 2160
Qy 2161 CACGACCAGCCGCTCCTTACCAAGTACCAACCATAGGGGTGTATGGCGTGCCAGGATCAG 2220
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2161 CACGACCAGCCGCTCCTTACCAAGTACCAACCATAGGGGTGTATGGCGTGCCAGGATCAG 2220
Qy 2221 GCAAGTCTGGCATCATTAAAAGCGCAGTCACCAAAAAAGATCTAGTGGTGAGCGCCAAGA 2280
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2221 GCAAGTCTGGCATCATTAAAAGCGCAGTCACCAAAAAAGATCTAGTGGTGAGCGCCAAGA 2280
Qy 2281 AAGAAAACTGTGCAGAAATTATAAGGGACGTCAAGAAAATGAAAGGGCTGGACGTCAATG 2340
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2281 AAGAAAACTGTGCAGAAATTATAAGGGACGTCAAGAAAATGAAAGGGCTGGACGTCAATG 2340
Qy 2341 CCAGAACTGTGGACTCAGTGCTCTTGAATGGATGCAAACACCCCGTAGAGACCCTGTATA 2400
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2341 CCAGAACTGTGGACTCAGTGCTCTTGAATGGATGCAAACACCCCGTAGAGACCCTGTATA 2400
Qy 2401 TTGACGAAGCTTTTGCTTGTCATGCAGGTACTCTCAGAGCGCTCATAGCCATTATAAGAC 2460
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2401 TTGACGAAGCTTTTGCTTGTCATGCAGGTACTCTCAGAGCGCTCATAGCCATTATAAGAC 2460
Qy 2461 CTAAAAAGGCAGTGCTCTGCGGGGATCCCAAACAGTGCGGTTTTTTTAACATGATGTGCC 2520
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2461 CTAAAAAGGCAGTGCTCTGCGGGGATCCCAAACAGTGCGGTTTTTTTAACATGATGTGCC 2520
Qy 2521 TGAAAGTGCATTTTAACCACGAGATTTGCACACAAGTCTTCCACAAAAGCATCTCTCGCC 2580
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2521 TGAAAGTGCATTTTAACCACGAGATTTGCACACAAGTCTTCCACAAAAGCATCTCTCGCC 2580
Qy 2581 GTTGCACTAAATCTGTGACTTCGGTCGTCTCAACCTTGTTTTACGACAAAAAAATGAGAA 2640
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2581 GTTGCACTAAATCTGTGACTTCGGTCGTCTCAACCTTGTTTTACGACAAAAAAATGAGAA 2640
Qy 2641 CGACGAATCCGAAAGAGACTAAGATTGTGATTGACACTACCGGCAGTACCAAACCTAAGC 2700
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2641 CGACGAATCCGAAAGAGACTAAGATTGTGATTGACACTACCGGCAGTACCAAACCTAAGC 2700
Qy 2701 AGGACGATCTCATTCTCACTTGTTTCAGAGGGTGGGTGAAGCAGTTGCAAATAGATTACA 2760
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2701 AGGACGATCTCATTCTCACTTGTTTCAGAGGGTGGGTGAAGCAGTTGCAAATAGATTACA 2760
Qy 2761 AAGGCAACGAAATAATGACGGCAGCTGCCTCTCAAGGGCTGACCCGTAAAGGTGTGTATG 2820
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2761 AAGGCAACGAAATAATGACGGCAGCTGCCTCTCAAGGGCTGACCCGTAAAGGTGTGTATG 2820
Qy 2821 CCGTTCGGTACAAGGTGAATGAAAATCCTCTGTACGCACCCACCTCAGAACATGTGAACG 2880
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2821 CCGTTCGGTACAAGGTGAATGAAAATCCTCTGTACGCACCCACCTCAGAACATGTGAACG 2880
Qy 2881 TCCTACTGACCCGCACGGAGGACCGCATCGTGTGGAAAACACTAGCCGGCGACCCATGGA 2940
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2881 TCCTACTGACCCGCACGGAGGACCGCATCGTGTGGAAAACACTAGCCGGCGACCCATGGA 2940
Qy 2941 TAAAAACACTGACTGCCAAGTACCCTGGGAATTTCACTGCCACGATAGAGGAGTGGCAAG 3000
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2941 TAAAAACACTGACTGCCAAGTACCCTGGGAATTTCACTGCCACGATAGAGGAGTGGCAAG 3000
Qy 3001 CAGAGCATGATGCCATCATGAGGCACATCTTGGAGAGACCGGACCCTACCGACGTCTTCC 3060
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3001 CAGAGCATGATGCCATCATGAGGCACATCTTGGAGAGACCGGACCCTACCGACGTCTTCC 3060
Qy 3061 AGAATAAGGCAAACGTGTGTTGGGCCAAGGCTTTAGTGCCGGTGCTGAAGACCGCTGGCA 3120
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3061 AGAATAAGGCAAACGTGTGTTGGGCCAAGGCTTTAGTGCCGGTGCTGAAGACCGCTGGCA 3120
Qy 3121 TAGACATGACCACTGAACAATGGAACACTGTGGATTATTTTGAAACGGACAAAGCTCACT 3180
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3121 TAGACATGACCACTGAACAATGGAACACTGTGGATTATTTTGAAACGGACAAAGCTCACT 3180
Qy 3181 CAGCAGAGATAGTATTGAACCAACTATGCGTGAGGTTCTTTGGACTCGATCTGGACTCCG 3240
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3181 CAGCAGAGATAGTATTGAACCAACTATGCGTGAGGTTCTTTGGACTCGATCTGGACTCCG 3240
Qy 3241 GTCTATTTTCTGCACCCACTGTTCCGTTATCCATTAGGAATAATCACTGGGATAACTCCC 3300
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3241 GTCTATTTTCTGCACCCACTGTTCCGTTATCCATTAGGAATAATCACTGGGATAACTCCC 3300
Qy 3301 CGTCGCCTAACATGTACGGGCTGAATAAAGAAGTGGTCCGTCAGCTCTCTCGCAGGTACC 3360
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3301 CGTCGCCTAACATGTACGGGCTGAATAAAGAAGTGGTCCGTCAGCTCTCTCGCAGGTACC 3360
Qy 3361 CACAACTGCCTCGGGCAGTTGCCACTGGAAGAGTCTATGACATGAACACTGGTACACTGC 3420
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3361 CACAACTGCCTCGGGCAGTTGCCACTGGAAGAGTCTATGACATGAACACTGGTACACTGC 3420
Qy 3421 GCAATTATGATCCGCGCATAAACCTAGTACCTGTAAACAGAAGACTGCCTCATGCTTTAG 3480
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3421 GCAATTATGATCCGCGCATAAACCTAGTACCTGTAAACAGAAGACTGCCTCATGCTTTAG 3480
Qy 3481 TCCTCCACCATAATGAACACCCACAGAGTGACTTTTCTTCATTCGTCAGCAAATTGAAGG 3540
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3481 TCCTCCACCATAATGAACACCCACAGAGTGACTTTTCTTCATTCGTCAGCAAATTGAAGG 3540
Qy 3541 GCAGAACTGTCCTGGTGGTCGGGGAAAAGTTGTCCGTCCCAGGCAAAATGGTTGACTGGT 3600
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3541 GCAGAACTGTCCTGGTGGTCGGGGAAAAGTTGTCCGTCCCAGGCAAAATGGTTGACTGGT 3600
Qy 3601 TGTCAGACCGGCCTGAGGCTACCTTCAGAGCTCGGCTGGATTTAGGCATCCCAGGTGATG 3660
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3601 TGTCAGACCGGCCTGAGGCTACCTTCAGAGCTCGGCTGGATTTAGGCATCCCAGGTGATG 3660
Qy 3661 TGCCCAAATATGACATAATATTTGTTAATGTGAGGACCCCATATAAATACCATCACTATC 3720
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3661 TGCCCAAATATGACATAATATTTGTTAATGTGAGGACCCCATATAAATACCATCACTATC 3720
Qy 3721 AGCAGTGTGAAGACCATGCCATTAAGCTTAGCATGTTGACCAAGAAAGCTTGTCTGCATC 3780
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3721 AGCAGTGTGAAGACCATGCCATTAAGCTTAGCATGTTGACCAAGAAAGCTTGTCTGCATC 3780
Qy 3781 TGAATCCCGGCGGAACCTGTGTCAGCATAGGTTATGGTTACGCTGACAGGGCCAGCGAAA 3840
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3781 TGAATCCCGGCGGAACCTGTGTCAGCATAGGTTATGGTTACGCTGACAGGGCCAGCGAAA 3840
Qy 3841 GCATCATTGGTGCTATAGCGCGGCAGTTCAAGTTTTCCCGGGTATGCAAACCGAAATCCT 3900
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3841 GCATCATTGGTGCTATAGCGCGGCAGTTCAAGTTTTCCCGGGTATGCAAACCGAAATCCT 3900
Qy 3901 CACTTGAAGAGACGGAAGTTCTGTTTGTATTCATTGGGTACGATCGCAAGGCCCGTACGC 3960
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3901 CACTTGAAGAGACGGAAGTTCTGTTTGTATTCATTGGGTACGATCGCAAGGCCCGTACGC 3960
Qy 3961 ACAATCCTTACAAGCTTTCATCAACCTTGACCAACATTTATACAGGTTCCAGACTCCACG 4020
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 3961 ACAATCCTTACAAGCTTTCATCAACCTTGACCAACATTTATACAGGTTCCAGACTCCACG 4020
Qy 4021 AAGCCGGATGTGCACCCTCATATCATGTGGTGCGAGGGGATATTGCCACGGCCACCGAAG 4080
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4021 AAGCCGGATGTGCACCCTCATATCATGTGGTGCGAGGGGATATTGCCACGGCCACCGAAG 4080
Qy 4081 GAGTGATTATAAATGCTGCTAACAGCAAAGGACAACCTGGCGGAGGGGTGTGCGGAGCGC 4140
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4081 GAGTGATTATAAATGCTGCTAACAGCAAAGGACAACCTGGCGGAGGGGTGTGCGGAGCGC 4140
Qy 4141 TGTATAAGAAATTCCCGGAAAGCTTCGATTTACAGCCGATCGAAGTAGGAAAAGCGCGAC 4200
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4141 TGTATAAGAAATTCCCGGAAAGCTTCGATTTACAGCCGATCGAAGTAGGAAAAGCGCGAC 4200
Qy 4201 TGGTCAAAGGTGCAGCTAAACATATCATTCATGCCGTAGGACCAAACTTCAACAAAGTTT 4260
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4201 TGGTCAAAGGTGCAGCTAAACATATCATTCATGCCGTAGGACCAAACTTCAACAAAGTTT 4260
Qy 4261 CGGAGGTTGAAGGTGACAAACAGTTGGCAGAGGCTTATGAGTCCATCGCTAAGATTGTCA 4320
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4261 CGGAGGTTGAAGGTGACAAACAGTTGGCAGAGGCTTATGAGTCCATCGCTAAGATTGTCA 4320
Qy 4321 ACGATAACAATTACAAGTCAGTAGCGATTCCACTGTTGTCCACCGGCATCTTTTCCGGGA 4380
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4321 ACGATAACAATTACAAGTCAGTAGCGATTCCACTGTTGTCCACCGGCATCTTTTCCGGGA 4380
Qy 4381 ACAAAGATCGACTAACCCAATCATTGAACCATTTGCTGACAGCTTTAGACACCACTGATG 4440
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4381 ACAAAGATCGACTAACCCAATCATTGAACCATTTGCTGACAGCTTTAGACACCACTGATG 4440
Qy 4441 CAGATGTAGCCATATACTGCAGGGACAAGAAATGGGAAATGACTCTCAAGGAAGCAGTGG 4500
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4441 CAGATGTAGCCATATACTGCAGGGACAAGAAATGGGAAATGACTCTCAAGGAAGCAGTGG 4500
Qy 4501 CTAGGAGAGAAGCAGTGGAGGAGATATGCATATCCGACGACTCTTCAGTGACAGAACCTG 4560
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4501 CTAGGAGAGAAGCAGTGGAGGAGATATGCATATCCGACGACTCTTCAGTGACAGAACCTG 4560
Qy 4561 ATGCAGAGCTGGTGAGGGTGCATCCGAAGAGTTCTTTGGCTGGAAGGAAGGGCTACAGCA 4620
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4561 ATGCAGAGCTGGTGAGGGTGCATCCGAAGAGTTCTTTGGCTGGAAGGAAGGGCTACAGCA 4620
Qy 4621 CAAGCGATGGCAAAACTTTCTCATATTTGGAAGGGACCAAGTTTCACCAGGCGGCCAAGG 4680
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4621 CAAGCGATGGCAAAACTTTCTCATATTTGGAAGGGACCAAGTTTCACCAGGCGGCCAAGG 4680
Qy 4681 ATATAGCAGAAATTAATGCCATGTGGCCCGTTGCAACGGAGGCCAATGAGCAGGTATGCA 4740
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4681 ATATAGCAGAAATTAATGCCATGTGGCCCGTTGCAACGGAGGCCAATGAGCAGGTATGCA 4740
Qy 4741 TGTATATCCTCGGAGAAAGCATGAGCAGTATTAGGTCGAAATGCCCCGTCGAAGAGTCGG 4800
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4741 TGTATATCCTCGGAGAAAGCATGAGCAGTATTAGGTCGAAATGCCCCGTCGAAGAGTCGG 4800
Qy 4801 AAGCCTCCACACCACCTAGCACGCTGCCTTGCTTGTGCATCCATGCCATGACTCCAGAAA 4860
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4801 AAGCCTCCACACCACCTAGCACGCTGCCTTGCTTGTGCATCCATGCCATGACTCCAGAAA 4860
Qy 4861 GAGTACAGCGCCTAAAAGCCTCACGTCCAGAACAAATTACTGTGTGCTCATCCTTTCCAT 4920
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4861 GAGTACAGCGCCTAAAAGCCTCACGTCCAGAACAAATTACTGTGTGCTCATCCTTTCCAT 4920
Qy 4921 TGCCGAAGTATAGAATCACTGGTGTGCAGAAGATCCAATGCTCCCAGCCTATATTGTTCT 4980
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4921 TGCCGAAGTATAGAATCACTGGTGTGCAGAAGATCCAATGCTCCCAGCCTATATTGTTCT 4980
Qy 4981 CACCGAAAGTGCCTGCGTATATTCATCCAAGGAAGTATCTCGTGGAAACACCACCGGTAG 5040
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 4981 CACCGAAAGTGCCTGCGTATATTCATCCAAGGAAGTATCTCGTGGAAACACCACCGGTAG 5040
Qy 5041 ACGAGACTCCGGAGCCATCGGCAGAGAACCAATCCACAGAGGGGACACCTGAACAACCAC 5100
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5041 ACGAGACTCCGGAGCCATCGGCAGAGAACCAATCCACAGAGGGGACACCTGAACAACCAC 5100
Qy 5101 CACTTATAACCGAGGATGAGACCAGGACTAGAACGCCTGAGCCGATCATCATCGAAGAGG 5160
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5101 CACTTATAACCGAGGATGAGACCAGGACTAGAACGCCTGAGCCGATCATCATCGAAGAGG 5160
Qy 5161 AAGAAGAGGATAGCATAAGTTTGCTGTCAGATGGCCCGACCCACCAGGTGCTGCAAGTCG 5220
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5161 AAGAAGAGGATAGCATAAGTTTGCTGTCAGATGGCCCGACCCACCAGGTGCTGCAAGTCG 5220
Qy 5221 AGGCAGACATTCACGGGCCGCCCTCTGTATCTAGCTCATCCTGGTCCATTCCTCATGCAT 5280
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5221 AGGCAGACATTCACGGGCCGCCCTCTGTATCTAGCTCATCCTGGTCCATTCCTCATGCAT 5280
Qy 5281 CCGACTTTGATGTGGACAGTTTATCCATACTTGACACCCTGGAGGGAGCTAGCGTGACCA 5340
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5281 CCGACTTTGATGTGGACAGTTTATCCATACTTGACACCCTGGAGGGAGCTAGCGTGACCA 5340
Qy 5341 GCGGGGCAACGTCAGCCGAGACTAACTCTTACTTCGCAAAGAGTATGGAGTTTCTGGCGC 5400
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5341 GCGGGGCAACGTCAGCCGAGACTAACTCTTACTTCGCAAAGAGTATGGAGTTTCTGGCGC 5400
Qy 5401 GACCGGTGCCTGCGCCTCGAACAGTATTCAGGAACCCTCCACATCCCGCTCCGCGCACAA 5460
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5401 GACCGGTGCCTGCGCCTCGAACAGTATTCAGGAACCCTCCACATCCCGCTCCGCGCACAA 5460
Qy 5461 GAACACCGTCACTTGCACCCAGCAGGGCCTGCTCGAGAACCAGCCTAGTTTCCACCCCGC 5520
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5461 GAACACCGTCACTTGCACCCAGCAGGGCCTGCTCGAGAACCAGCCTAGTTTCCACCCCGC 5520
Qy 5521 CAGGCGTGAATAGGGTGATCACTAGAGAGGAGCTCGAGGCGCTTACCCCGTCACGCACTC 5580
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5521 CAGGCGTGAATAGGGTGATCACTAGAGAGGAGCTCGAGGCGCTTACCCCGTCACGCACTC 5580
Qy 5581 CTAGCAGGTCGGTCTCGAGAACCAGCCTGGTCTCCAACCCGCCAGGCGTAAATAGGGTGA 5640
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5581 CTAGCAGGTCGGTCTCGAGAACCAGCCTGGTCTCCAACCCGCCAGGCGTAAATAGGGTGA 5640
Qy 5641 TTACAAGAGAGGAGTTTGAGGCGTTCGTAGCACAACAACAATGACGGTTTGATGCGGGTG 5700
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5641 TTACAAGAGAGGAGTTTGAGGCGTTCGTAGCACAACAACAATGACGGTTTGATGCGGGTG 5700
Qy 5701 CATACATCTTTTCCTCCGACACCGGTCAAGGGCATTTACAACAAAAATCAGTAAGGCAAA 5760
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5701 CATACATCTTTTCCTCCGACACCGGTCAAGGGCATTTACAACAAAAATCAGTAAGGCAAA 5760
Qy 5761 CGGTGCTATCCGAAGTGGTGTTGGAGAGGACCGAATTGGAGATTTCGTATGCCCCGCGCC 5820
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5761 CGGTGCTATCCGAAGTGGTGTTGGAGAGGACCGAATTGGAGATTTCGTATGCCCCGCGCC 5820
Qy 5821 TCGACCAAGAAAAAGAAGAATTACTACGCAAGAAATTACAGTTAAATCCCACACCTGCTA 5880
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5821 TCGACCAAGAAAAAGAAGAATTACTACGCAAGAAATTACAGTTAAATCCCACACCTGCTA 5880
Qy 5881 ACAGAAGCAGATACCAGTCCAGGAAGGTGGAGAACATGAAAGCCATAACAGCTAGACGTA 5940
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5881 ACAGAAGCAGATACCAGTCCAGGAAGGTGGAGAACATGAAAGCCATAACAGCTAGACGTA 5940
Qy 5941 TTCTGCAAGGCCTAGGGCATTATTTGAAGGCAGAAGGAAAAGTGGAGTGCTACCGAACCC 6000
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 5941 TTCTGCAAGGCCTAGGGCATTATTTGAAGGCAGAAGGAAAAGTGGAGTGCTACCGAACCC 6000
Qy 6001 TGCATCCTGTTCCTTTGTATTCATCTAGTGTGAACCGTGCCTTTTCAAGCCCCAAGGTCG 6060
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6001 TGCATCCTGTTCCTTTGTATTCATCTAGTGTGAACCGTGCCTTTTCAAGCCCCAAGGTCG 6060
Qy 6061 CAGTGGAAGCCTGTAACGCCATGTTGAAAGAGAACTTTCCGACTGTGGCTTCTTACTGTA 6120
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6061 CAGTGGAAGCCTGTAACGCCATGTTGAAAGAGAACTTTCCGACTGTGGCTTCTTACTGTA 6120
Qy 6121 TTATTCCAGAGTACGATGCCTATTTGGACATGGTTGACGGAGCTTCATGCTGCTTAGACA 6180
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6121 TTATTCCAGAGTACGATGCCTATTTGGACATGGTTGACGGAGCTTCATGCTGCTTAGACA 6180
Qy 6181 CTGCCAGTTTTTGCCCTGCAAAGCTGCGCAGCTTTCCAAAGAAACACTCCTATTTGGAAC 6240
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6181 CTGCCAGTTTTTGCCCTGCAAAGCTGCGCAGCTTTCCAAAGAAACACTCCTATTTGGAAC 6240
Qy 6241 CCACAATACGATCGGCAGTGCCTTCAGCGATCCAGAACACGCTCCAGAACGTCCTGGCAG 6300
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6241 CCACAATACGATCGGCAGTGCCTTCAGCGATCCAGAACACGCTCCAGAACGTCCTGGCAG 6300
Qy 6301 CTGCCACAAAAAGAAATTGCAATGTCACGCAAATGAGAGAATTGCCCGTATTGGATTCGG 6360
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6301 CTGCCACAAAAAGAAATTGCAATGTCACGCAAATGAGAGAATTGCCCGTATTGGATTCGG 6360
Qy 6361 CGGCCTTTAATGTGGAATGCTTCAAGAAATATGCGTGTAATAATGAATATTGGGAAACGT 6420
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6361 CGGCCTTTAATGTGGAATGCTTCAAGAAATATGCGTGTAATAATGAATATTGGGAAACGT 6420
Qy 6421 TTAAAGAAAACCCCATCAGGCTTACTGAAGAAAACGTGGTAAATTACATTACCAAATTAA 6480
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6421 TTAAAGAAAACCCCATCAGGCTTACTGAAGAAAACGTGGTAAATTACATTACCAAATTAA 6480
Qy 6481 AAGGACCAAAAGCTGCTGCTCTTTTTGCGAAGACACATAATTTGAATATGTTGCAGGACA 6540
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6481 AAGGACCAAAAGCTGCTGCTCTTTTTGCGAAGACACATAATTTGAATATGTTGCAGGACA 6540
Qy 6541 TACCAATGGACAGGTTTGTAATGGACTTAAAGAGAGACGTGAAAGTGACTCCAGGAACAA 6600
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6541 TACCAATGGACAGGTTTGTAATGGACTTAAAGAGAGACGTGAAAGTGACTCCAGGAACAA 6600
Qy 6601 AACATACTGAAGAACGGCCCAAGGTACAGGTGATCCAGGCTGCCGATCCGCTAGCAACAG 6660
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6601 AACATACTGAAGAACGGCCCAAGGTACAGGTGATCCAGGCTGCCGATCCGCTAGCAACAG 6660
Qy 6661 CGTATCTGTGCGGAATCCACCGAGAGCTGGTTAGGAGATTAAATGCGGTCCTGCTTCCGA 6720
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6661 CGTATCTGTGCGGAATCCACCGAGAGCTGGTTAGGAGATTAAATGCGGTCCTGCTTCCGA 6720
Qy 6721 ACATTCATACACTGTTTGATATGTCGGCTGAAGACTTTGACGCTATTATAGCCGAGCACT 6780
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6721 ACATTCATACACTGTTTGATATGTCGGCTGAAGACTTTGACGCTATTATAGCCGAGCACT 6780
Qy 6781 TCCAGCCTGGGGATTGTGTTCTGGAAACTGACATCGCGTCGTTTGATAAAAGTGAGGACG 6840
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6781 TCCAGCCTGGGGATTGTGTTCTGGAAACTGACATCGCGTCGTTTGATAAAAGTGAGGACG 6840
Qy 6841 ACGCCATGGCTCTGACCGCGTTAATGATTCTGGAAGACTTAGGTGTGGACGCAGAGCTGT 6900
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6841 ACGCCATGGCTCTGACCGCGTTAATGATTCTGGAAGACTTAGGTGTGGACGCAGAGCTGT 6900
Qy 6901 TGACGCTGATTGAGGCGGCTTTCGGCGAAATTTCATCAATACATTTGCCCACTAAAACTA 6960
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6901 TGACGCTGATTGAGGCGGCTTTCGGCGAAATTTCATCAATACATTTGCCCACTAAAACTA 6960
Qy 6961 AATTTAAATTCGGAGCCATGATGAAATCTGGAATGTTCCTCACACTGTTTGTGAACACAG 7020
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 6961 AATTTAAATTCGGAGCCATGATGAAATCTGGAATGTTCCTCACACTGTTTGTGAACACAG 7020
Qy 7021 TCATTAACATTGTAATCGCAAGCAGAGTGTTGAGAGAACGGCTAACCGGATCACCATGTG 7080
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7021 TCATTAACATTGTAATCGCAAGCAGAGTGTTGAGAGAACGGCTAACCGGATCACCATGTG 7080
Qy 7081 CAGCATTCATTGGAGATGACAATATCGTGAAAGGAGTCAAATCGGACAAATTAATGGCAG 7140
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7081 CAGCATTCATTGGAGATGACAATATCGTGAAAGGAGTCAAATCGGACAAATTAATGGCAG 7140
Qy 7141 ACAGGTGCGCCACCTGGTTGAATATGGAAGTCAAGATTATAGATGCTGTGGTGGGCGAGA 7200
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7141 ACAGGTGCGCCACCTGGTTGAATATGGAAGTCAAGATTATAGATGCTGTGGTGGGCGAGA 7200
Qy 7201 AAGCGCCTTATTTCTGTGGAGGGTTTATTTTGTGTGACTCCGTGACCGGCACAGCGTGCC 7260
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7201 AAGCGCCTTATTTCTGTGGAGGGTTTATTTTGTGTGACTCCGTGACCGGCACAGCGTGCC 7260
Qy 7261 GTGTGGCAGACCCCCTAAAAAGGCTGTTTAAGCTTGGCAAACCTCTGGCAGCAGACGATG 7320
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7261 GTGTGGCAGACCCCCTAAAAAGGCTGTTTAAGCTTGGCAAACCTCTGGCAGCAGACGATG 7320
Qy 7321 AACATGATGATGACAGGAGAAGGGCATTGCATGAAGAGTCAACACGCTGGAACCGAGTGG 7380
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7321 AACATGATGATGACAGGAGAAGGGCATTGCATGAAGAGTCAACACGCTGGAACCGAGTGG 7380
Qy 7381 GTATTCTTTCAGAGCTGTGCAAGGCAGTAGAATCAAGGTATGAAACCGTAGGAACTTCCA 7440
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7381 GTATTCTTTCAGAGCTGTGCAAGGCAGTAGAATCAAGGTATGAAACCGTAGGAACTTCCA 7440
Qy 7441 TCATAGTTATGGCCATGACTACTCTAGCTAGCAGTGTTAAATCATTCAGCTACCTGAGAG 7500
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7441 TCATAGTTATGGCCATGACTACTCTAGCTAGCAGTGTTAAATCATTCAGCTACCTGAGAG 7500
Qy 7501 GGGCCCCTATAACTCTCTACGGCTAACCTGAATGGACTACGACATAGTCTAGTCCGCCAA 7560
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 7501 GGGCCCCTATAACTCTCTACGGCTAACCTGAATGGACTACGACATAGTCTAGTCCGCCAA 7560
Alignment between SEQ ID NO: 18 (Db) and enterovirus D68 strain US/MO/14-18947 partial genome (ncbi.nlm.nih.gov/nuccore/KM851225) (Relevant to instant cl. 35)
Result Query
No. Score Match Length DB ID Description
----------------------------------------------------------------------------
1 1609.4 22.0 12956 1 NASEQ2_03052025_113200
c 2 25.8 0.4 12956 1 NASEQ2_03052025_113200
ALIGNMENTS
RESULT 1
NASEQ2_03052025_113200
Query Match 22.0%; Score 1609.4; DB 1; Length 12956;
Best Local Similarity 76.3%;
Matches 1979; Conservative 0; Mismatches 616; Indels 0; Gaps 0;
Qy 697 ATGGGAGCTCAGGTTACTAGACAACAAACTGGCACTCATGAAAATGCCAACATTGCCACA 756
||||| |||||||| || || || ||||| || |||||||||||||||||||| || ||
Db 7562 ATGGGTGCTCAGGTAACCAGGCAGCAAACCGGTACTCATGAAAATGCCAACATAGCTACT 7621
Qy 757 AATGGATCTCATATCACATACAATCAGATAAACTTTTACAAGGATAGCTATGCGGCTTCA 816
||||| || ||||| || |||||||| || || || ||||||||||| || || || ||
Db 7622 AATGGCTCCCATATTACGTACAATCAAATCAATTTCTACAAGGATAGTTACGCTGCGTCC 7681
Qy 817 GCCAGCAAGCAGGATTTTTCACAGGACCCATCAAAATTCACTGAACCAGTAGTGGAAGGT 876
|| |||||||| || ||||| || || || || ||||| ||||| |||||
Db 7682 GCTTCTAAGCAGGACTTCAGTCAGGATCCTAGCAAGTTTACGGAACCCGTAGTTGAAGGC 7741
Qy 877 TTAAAAGCAGGGGCGCCAGTTTTGAAATCTCCTAGTGCTGAGGCATGTGGCTACAGTGAT 936
| || |||||||| || || | || || || ||||| ||||| || || ||| |||
Db 7742 CTTAAGGCAGGGGCACCTGTCCTTAAGTCACCGAGTGCGGAGGCTTGCGGTTACTCTGAC 7801
Qy 937 AGAGTATTACAGCTCAAATTAGGAAATTCAGCTATTGTCACCCAGGAAGCAGCGAACTAC 996
||||| | ||||| || | || || || || || || || |||||||| || |||||
Db 7802 CGAGTACTGCAGCTTAAGCTCGGGAACTCTGCCATAGTTACGCAGGAAGCGGCAAACTAT 7861
Qy 997 TGCTGCGCTTATGGTGAATGGCCCAATTACTTACCAGACCATGAAGCAGTAGCCATTGAT 1056
|||||||| || || || ||||| || ||| | ||||||||||| || || || || ||
Db 7862 TGCTGCGCGTACGGGGAGTGGCCGAACTACCTGCCAGACCATGAGGCGGTCGCTATAGAC 7921
Qy 1057 AAACCTACACAACCAGAAACTGCTACAGATAGATTCTACACTTTGAAATCAGTCAAATGG 1116
|| || |||||||| || || || || ||| | ||||| ||| | ||| || ||||||
Db 7922 AAGCCAACACAACCTGAGACAGCCACGGATCGGTTCTATACTCTTAAAAGCGTAAAATGG 7981
Qy 1117 GAAACTGGAAGCACAGGATGGTGGTGGAAACTACCCGATGCACTGAATAATATAGGCATG 1176
|| ||||| |||||||||||||||||| || || ||||| || || ||||| || |||
Db 7982 GAGACTGGCTCCACAGGATGGTGGTGGAAGCTCCCAGATGCCCTTAACAATATCGGGATG 8041
Qy 1177 TTTGGACAGAATGTGCAGCATCACTACCTATATAGATCTGGTTTCTTGATTCATGTGCAG 1236
||||| |||||||| || || || ||||| ||| | ||| ||| | ||||| || |||
Db 8042 TTTGGCCAGAATGTTCAACACCATTACCTGTATCGCAGTGGCTTCCTCATTCACGTCCAG 8101
Qy 1237 TGTAATGCCACAAAATTCCATCAAGGTGCCTTATTAGTGGTAGCAATTCCAGAACATCAG 1296
|||||||||||||| || ||||| || || | | ||||| || || ||||| ||||||
Db 8102 TGTAATGCCACAAAGTTTCATCAGGGGGCTCTCCTTGTGGTGGCGATCCCAGAGCATCAG 8161
Qy 1297 AGGGGAGCGCACAACACCAACACTAGCCCAGGGTTTGATGATATAATGAAAGGTGAAGAA 1356
||||| || || || || || ||||| || || || ||||||||||||||||| || |||
Db 8162 AGGGGTGCACATAATACTAATACTAGTCCTGGTTTCGATGATATAATGAAAGGGGAGGAA 8221
Qy 1357 GGAGGGACCTTCAATCATCCATATGTCCTTGATGATGGAACATCATTGGCTTGTGCGACG 1416
|||||||| || |||||||| |||||||| ||||| || || |||||||| |||||||||
Db 8222 GGAGGGACGTTTAATCATCCTTATGTCCTGGATGACGGGACCTCATTGGCGTGTGCGACG 8281
Qy 1417 ATATTTCCACATCAGTGGATAAATCTGAGAACCAACAATTCAGCAACAATTGTTCTTCCC 1476
|| || || || |||||||| ||||| | ||||| || || || || || |||||
Db 8282 ATCTTCCCTCACCAGTGGATTAATCTCCGGACCAATAACAGTGCGACTATCGTACTTCCA 8341
Qy 1477 TGGATGAATGCTGCTCCAATGGATTTCCCACTTAGACATAATCAGTGGACGCTAGCAATA 1536
|||||||| || ||||| |||||||| || || || |||||||||||||| | || ||
Db 8342 TGGATGAACGCGGCTCCGATGGATTTTCCCCTGAGGCATAATCAGTGGACATTGGCTATT 8401
Qy 1537 ATACCAGTGGTGCCATTAGGCACGCGTACAACATCAAGTATGGTCCCAATAACAGTTTCA 1596
|| || || || || | || || | || || ||||| || ||||| || ||
Db 8402 ATTCCGGTCGTACCCCTGGGTACTAGAACCACTAGCTCAATGGTTCCCATAACTGTATCT 8461
Qy 1597 ATCGCTCCAATGTGTTGTGAGTTTAATGGACTTAGACACGCCATTACTCAAGGTGTCCCA 1656
|| || |||||||| ||||| |||||||| || | ||||| || || ||||| || ||
Db 8462 ATTGCGCCAATGTGCTGTGAATTTAATGGGCTCCGGCACGCTATCACACAAGGCGTTCCT 8521
Qy 1657 ACATACCTTTTACCAGGCTCGGGACAATTCCTAACAACTGATGATCATAGCTCTGCACCA 1716
|| || || || |||||||| || || ||||| || |||||||| |||||||| |||||
Db 8522 ACGTATCTCTTGCCAGGCTCAGGTCAGTTCCTCACTACTGATGACCATAGCTCCGCACCT 8581
Qy 1717 GCTCTCCCGTGTTTCAACCCAACTCCAGAAATGCATATCCCAGGGCAGGTCCGTAACATG 1776
|| ||||| ||||| |||||||| || || ||||||||||||||||| ||||| ||||||
Db 8582 GCCCTCCCCTGTTTTAACCCAACACCCGAGATGCATATCCCAGGGCAAGTCCGAAACATG 8641
Qy 1777 CTAGAAGTGGTCCAAGTGGAATCAATGATGGAGATTAATAACACAGAAAGTGCAGTTGGC 1836
|| || || || || || ||||| ||||||||||| ||||||||||| ||||| || ||
Db 8642 CTTGAGGTTGTTCAGGTAGAATCTATGATGGAGATCAATAACACAGAGAGTGCGGTAGGG 8701
Qy 1837 ATGGAGCGTCTTAAGGTTGATATATCAGCATTGACAGATGTCGATCAATTGTTATTCAAC 1896
|||||||| ||||||||||| || || |||||||| ||||| || ||| | || || |||
Db 8702 ATGGAGCGCCTTAAGGTTGACATCTCCGCATTGACCGATGTTGACCAACTTTTGTTTAAC 8761
Qy 1897 ATTCCACTGGACATACAGTTGGATGGGCCACTTAGAAACACTTTAGTAGGAAACATATCT 1956
||||| ||||| |||||| | ||||| || | | ||||| || || ||||| || ||
Db 8762 ATTCCCCTGGATATACAGCTCGATGGCCCCTTGCGGAACACGTTGGTCGGAAATATCTCC 8821
Qy 1957 AGATATTACACTCATTGGTCTGGATCCCTAGAAATGACGTTTATGTTTTGTGGCAGCTTC 2016
|| || |||||||||||||| || || |||||||| ||||||||||| ||||| |||
Db 8822 AGGTACTACACTCATTGGTCCGGCAGTCTCGAAATGACATTTATGTTTTGCGGCAGTTTC 8881
Qy 2017 ATGGCAGCGGGAAAATTAATCCTGTGCTATACTCCTCCAGGTGGATCATGCCCGACAACC 2076
||||||||||| ||| | |||||||| ||||| || ||||| || || || || ||
Db 8882 ATGGCAGCGGGCAAACTGATCCTGTGTTATACACCCCCAGGCGGTAGTTGTCCAACGACG 8941
Qy 2077 AGAGAGACCGCCATGTTAGGTACACATATTGTTTGGGATTTTGGATTACAATCTAGTGTA 2136
||||||| || ||| | || |||||||| || ||||||||||| || ||||| ||
Db 8942 CGAGAGACGGCGATGCTCGGCACACATATAGTGTGGGATTTTGGCTTGCAATCCTCAGTT 9001
Qy 2137 ACCCTGATAATACCTTGGATTAGTGGATCCCACTACAGGATGTTTAATAATGATGCTAAG 2196
||||| || ||||| ||||| || || ||| || || ||||| || ||||| |||||
Db 9002 ACCCTCATCATACCGTGGATAAGCGGCAGCCATTATAGAATGTTCAACAATGACGCTAAA 9061
Qy 2197 TCAACTAATGCCAACGTTGGCTATGTCACTTGTTTTATGCAGACCAATCTGATAGTCCCT 2256
|| || ||||| || || ||||| || || ||||||||||| ||||| || || |||
Db 9062 AGTACGAACGCCAATGTGGGATATGTGACCTGCTTTATGCAGACGAATCTCATCGTACCT 9121
Qy 2257 AGTGAATCCTCTGACACGTGTTCCTTGATAGGGTTCATAGCAGCAAAAGATGATTTCTCC 2316
||| ||||| ||||| || |||||||| |||||||| ||||| || ||||||
Db 9122 TCTGAGTCCTCAGACACATGCAGTTTGATAGGTTTCATAGCCGCAAAGGACGATTTCAGT 9181
Qy 2317 CTCAGATTAATGAGAGACAGCCCTGACATTGGACAACTAGACCATTTACATGCAGCAGAG 2376
|| ||| | ||| | ||||| || |||||||| ||||| || || | ||||| || |||
Db 9182 CTTAGACTTATGCGGGACAGTCCGGACATTGGTCAACTGGATCACCTTCATGCTGCGGAG 9241
Qy 2377 GCAGCCTACCAGATCGAGAGCATCATCAAAACAGCGACCGACACTGTGAAAAGTGAGATT 2436
||||| || |||||||| || || ||||| || |||||||| || || |||||
Db 9242 GCAGCATATCAGATCGAATCAATAATTAAAACTGCTACCGACACAGTCAAGTCCGAGATA 9301
Qy 2437 AATGCTGAACTTGGTGTGGTCCCTAGCTTAAATGCAGTTGAAACAGGTGCAACTTCTAAC 2496
|| |||||||| || || ||||| || | |||||||| ||||| || || ||||||||
Db 9302 AACGCTGAACTGGGCGTCGTCCCGAGTCTTAATGCAGTGGAAACCGGAGCCACTTCTAAT 9361
Qy 2497 ACTGAACCAGAAGAAGCCATACAAACTCGCACAGTGATAAATCAGCACGGTGTATCCGAG 2556
||||| ||||||||||| || |||||||| || ||||| || || ||||||||| ||||
Db 9362 ACTGAGCCAGAAGAAGCAATTCAAACTCGAACTGTGATCAACCAACACGGTGTAAGCGAG 9421
Qy 2557 ACTCTAGTGGAGAATTTTCTCAGTAGAGCAGCTTTGGTATCAAAGAGAAGTTTTGAATAC 2616
||| | || || ||||| ||| ||||| || ||||||||||| ||||||||||| ||
Db 9422 ACTTTGGTAGAAAATTTCCTCTCCAGAGCCGCCTTGGTATCAAAAAGAAGTTTTGAGTAT 9481
Qy 2617 AAAGATCATACTTCGTCTACAGCACGAGCAGACAAGAACTTTTTCAAATGGACAATTAAC 2676
||||| || || ||||||||||| |||||||||||||| || |||||||| || ||
Db 9482 AAAGACCACACGAGCTCTACAGCACGCGCAGACAAGAACTTCTTTAAATGGACGATAAAT 9541
Qy 2677 ACCAGATCCTTTGTACAGTTAAGAAGAAAATTAGAATTATTCACATACCTTAGATTTGAT 2736
|||||| ||||||||| | | || ||||| || | ||||||||||| |||||||
Db 9542 ACCAGAAGTTTTGTACAGCTCCGCAGGAAATTGGAGCTCTTCACATACCTCCGATTTGAC 9601
Qy 2737 GCTGAGATCACTATACTCACAACTGTAGCAGTGAATGGTAGTGGTAATAATACATACGTG 2796
|| || || || || | || || || || || ||||||||||| ||||| || |||||
Db 9602 GCGGAAATAACAATTTTGACCACAGTTGCGGTTAATGGTAGTGGAAATAACACGTACGTA 9661
Qy 2797 GGTCTTCCTGACTTGACACTTCAAGCAATGTTTGTACCCACTGGTGCTCTTACCCCAGAA 2856
|| | ||||| ||||||| || || |||||||| || |||||||| || || || ||
Db 9662 GGCTTGCCTGATCTGACACTGCAGGCCATGTTTGTCCCTACTGGTGCACTCACTCCGGAG 9721
Qy 2857 AAGCAGGACTCATTCCACTGGCAGTCAGGCAGTAATGCTAGTGTATTCTTTAAAATCTCC 2916
|| |||||||| ||||| |||||| || ||||| || ||||| |||||||||
Db 9722 AAACAGGACTCCTTCCATTGGCAGAGCGGGTCAAATGCGTCAGTGTTCTTCAAAATCTCC 9781
Qy 2917 GACCCCCCAGCCAGAATAACCATACCTTTTATGTGCATTAACTCAGCATACTCAGTTTTT 2976
|| ||||| || || || || || || |||||||| || || || || ||||||
Db 9782 GATCCCCCCGCGAGGATCACTATTCCCTTTATGTGTATAAATAGCGCCTATAGCGTTTTT 9841
Qy 2977 TATGATGGCTTTGCCGGATTTGAGAAAAACGGTCTGTATGGAATAAATCCAGCTGACACT 3036
|| |||||||||||||| ||||| || || || |||| || || ||||| || || ||
Db 9842 TACGATGGCTTTGCCGGCTTTGAAAAGAATGGGTTGTACGGGATTAATCCGGCCGATACG 9901
Qy 3037 ATTGGTAACTTATGTGTTAGAATAGTGAATGAACACCAACCAGTTGGTTTCACAGTGACC 3096
|| |||||| | ||||| | ||||| || |||||||| ||||| |||||||| || |||
Db 9902 ATAGGTAACCTGTGTGTACGCATAGTTAACGAACACCAGCCAGTGGGTTTCACTGTAACC 9961
Qy 3097 GTTAGGGTTTACATGAAGCCTAAACACATAAAAGCATGGGCACCACGACCACCACGAACT 3156
||| | || |||||||| ||||| ||||| || || ||||||||| | ||||| ||||
Db 9962 GTTCGAGTGTACATGAAACCTAAGCACATCAAGGCTTGGGCACCAAGGCCACCGAGAACC 10021
Qy 3157 CTGCCATATATGAGTATTGCAAATGCAAATTACAAAGGTAAAGAAAGAGCACCAAATGCG 3216
|| ||||| ||||| ||||| ||||||||||| || || ||||| |||||||| || |||
Db 10022 CTCCCATACATGAGCATTGCTAATGCAAATTATAAGGGAAAAGAGAGAGCACCGAACGCG 10081
Qy 3217 CTCAGTGCTATAATTGGCAATAGAGACAGTGTCAAAACCATGCCTCATAATATAGTGAAC 3276
| ||| || || |||||| | ||| ||||| || ||||| ||||||||||| ||
Db 10082 TTGTCTGCAATTATCGGCAATCGGGACTCAGTCAAGACTATGCCACATAATATAGTCAAT 10141
Qy 3277 ACTGGTCCAGGCTTC 3291
|| | || || |
Db 10142 ACCTGACCCCTCTCC 10156
Alignment of instant SEQ ID NO: 18’s pos. from 7561-10147 following Expasy® based translation (Qy) compared to structural protein (VP1-VP4)of KM851225.1 (Db, pos. 697-3279).
Match 100.0%; Score 4568; DB 1; Length 861;
Best Local Similarity 100.0%;
Matches 861; Conservative 0; Mismatches 0; Indels 0; Gaps 0;
Qy 1 MGAQVTRQQTGTHENANIATNGSHITYNQINFYKDSYAASASKQDFSQDPSKFTEPVVEG 60
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1 MGAQVTRQQTGTHENANIATNGSHITYNQINFYKDSYAASASKQDFSQDPSKFTEPVVEG 60
Qy 61 LKAGAPVLKSPSAEACGYSDRVLQLKLGNSAIVTQEAANYCCAYGEWPNYLPDHEAVAID 120
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 61 LKAGAPVLKSPSAEACGYSDRVLQLKLGNSAIVTQEAANYCCAYGEWPNYLPDHEAVAID 120
Qy 121 KPTQPETATDRFYTLKSVKWETGSTGWWWKLPDALNNIGMFGQNVQHHYLYRSGFLIHVQ 180
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 121 KPTQPETATDRFYTLKSVKWETGSTGWWWKLPDALNNIGMFGQNVQHHYLYRSGFLIHVQ 180
Qy 181 CNATKFHQGALLVVAIPEHQRGAHNTNTSPGFDDIMKGEEGGTFNHPYVLDDGTSLACAT 240
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 181 CNATKFHQGALLVVAIPEHQRGAHNTNTSPGFDDIMKGEEGGTFNHPYVLDDGTSLACAT 240
Qy 241 IFPHQWINLRTNNSATIVLPWMNAAPMDFPLRHNQWTLAIIPVVPLGTRTTSSMVPITVS 300
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 241 IFPHQWINLRTNNSATIVLPWMNAAPMDFPLRHNQWTLAIIPVVPLGTRTTSSMVPITVS 300
Qy 301 IAPMCCEFNGLRHAITQGVPTYLLPGSGQFLTTDDHSSAPALPCFNPTPEMHIPGQVRNM 360
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 301 IAPMCCEFNGLRHAITQGVPTYLLPGSGQFLTTDDHSSAPALPCFNPTPEMHIPGQVRNM 360
Qy 361 LEVVQVESMMEINNTESAVGMERLKVDISALTDVDQLLFNIPLDIQLDGPLRNTLVGNIS 420
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 361 LEVVQVESMMEINNTESAVGMERLKVDISALTDVDQLLFNIPLDIQLDGPLRNTLVGNIS 420
Qy 421 RYYTHWSGSLEMTFMFCGSFMAAGKLILCYTPPGGSCPTTRETAMLGTHIVWDFGLQSSV 480
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 421 RYYTHWSGSLEMTFMFCGSFMAAGKLILCYTPPGGSCPTTRETAMLGTHIVWDFGLQSSV 480
Qy 481 TLIIPWISGSHYRMFNNDAKSTNANVGYVTCFMQTNLIVPSESSDTCSLIGFIAAKDDFS 540
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 481 TLIIPWISGSHYRMFNNDAKSTNANVGYVTCFMQTNLIVPSESSDTCSLIGFIAAKDDFS 540
Qy 541 LRLMRDSPDIGQLDHLHAAEAAYQIESIIKTATDTVKSEINAELGVVPSLNAVETGATSN 600
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 541 LRLMRDSPDIGQLDHLHAAEAAYQIESIIKTATDTVKSEINAELGVVPSLNAVETGATSN 600
Qy 601 TEPEEAIQTRTVINQHGVSETLVENFLSRAALVSKRSFEYKDHTSSTARADKNFFKWTIN 660
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 601 TEPEEAIQTRTVINQHGVSETLVENFLSRAALVSKRSFEYKDHTSSTARADKNFFKWTIN 660
Qy 661 TRSFVQLRRKLELFTYLRFDAEITILTTVAVNGSGNNTYVGLPDLTLQAMFVPTGALTPE 720
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 661 TRSFVQLRRKLELFTYLRFDAEITILTTVAVNGSGNNTYVGLPDLTLQAMFVPTGALTPE 720
Qy 721 KQDSFHWQSGSNASVFFKISDPPARITIPFMCINSAYSVFYDGFAGFEKNGLYGINPADT 780
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 721 KQDSFHWQSGSNASVFFKISDPPARITIPFMCINSAYSVFYDGFAGFEKNGLYGINPADT 780
Qy 781 IGNLCVRIVNEHQPVGFTVTVRVYMKPKHIKAWAPRPPRTLPYMSIANANYKGKERAPNA 840
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 781 IGNLCVRIVNEHQPVGFTVTVRVYMKPKHIKAWAPRPPRTLPYMSIANANYKGKERAPNA 840
Qy 841 LSAIIGNRDSVKTMPHNIVNT 861
|||||||||||||||||||||
Db 841 LSAIIGNRDSVKTMPHNIVNT 861
Alignment of 3CD protease (Qy – KM851225.1; Db-instant SEQ ID NO: 18)
Query Match 100.0%; Score 3385; DB 1; Length 641;
Best Local Similarity 100.0%;
Matches 640; Conservative 0; Mismatches 0; Indels 0; Gaps 0;
Qy 1 GPGFDFAQAIMKKNTVIARTEKGEFTMLGVYDRVAVIPTHASVGETIYINDVETKVLDAC 60
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2 GPGFDFAQAIMKKNTVIARTEKGEFTMLGVYDRVAVIPTHASVGETIYINDVETKVLDAC 61
Qy 61 ALRDLTDTNLEITIVKLDRNQKFRDIRHFLPRYEDDYNDAVLSVHTSKFPNMYIPVGQVT 120
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 62 ALRDLTDTNLEITIVKLDRNQKFRDIRHFLPRYEDDYNDAVLSVHTSKFPNMYIPVGQVT 121
Qy 121 NYGFLNLGGTPTHRILMYNFPTRAGQCGGVVTTTGKVIGIHVGGNGAQGFAAMLLHSYFS 180
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 122 NYGFLNLGGTPTHRILMYNFPTRAGQCGGVVTTTGKVIGIHVGGNGAQGFAAMLLHSYFS 181
Qy 181 DTQGEIVSSEKSGVCINAPAKTKLQPSVFHQVFEGSKEPAVLNPKDPRLKTDFEEAIFSK 240
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 182 DTQGEIVSSEKSGVCINAPAKTKLQPSVFHQVFEGSKEPAVLNPKDPRLKTDFEEAIFSK 241
Qy 241 YTGNKIMLMDEYMEEAVDHYVGCLEPLDISVDPIPLESAMYGMDGLEALDLTTSAGFPYL 300
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 242 YTGNKIMLMDEYMEEAVDHYVGCLEPLDISVDPIPLESAMYGMDGLEALDLTTSAGFPYL 301
Qy 301 LQGKKKRDIFNRHTRDTSEMTKMLEKYGVDLPFVTFVKDELRSREKVEKGKSRLIEASSL 360
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 302 LQGKKKRDIFNRHTRDTSEMTKMLEKYGVDLPFVTFVKDELRSREKVEKGKSRLIEASSL 361
Qy 361 NDSVAMRVAFGNLYATFHNNPGTATGSAVGCDPDIFWSKIPILLDGEIFAFDYTGYDASL 420
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 362 NDSVAMRVAFGNLYATFHNNPGTATGSAVGCDPDIFWSKIPILLDGEIFAFDYTGYDASL 421
Qy 421 SPVWFACLKKVLIKLGYTHQTSFIDYLCHSVHLYKDKKYIVNGGMPSGSSGTSIFNTMIN 480
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 422 SPVWFACLKKVLIKLGYTHQTSFIDYLCHSVHLYKDKKYIVNGGMPSGSSGTSIFNTMIN 481
Qy 481 NIIIRTLLIRVYKGIDLDQFKMIAYGDDVIASYPHKIDPGLLAEAGKQYGLVMTPADKGT 540
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 482 NIIIRTLLIRVYKGIDLDQFKMIAYGDDVIASYPHKIDPGLLAEAGKQYGLVMTPADKGT 541
Qy 541 SFIDTNWENVTFLKRYFRADDQYPFLIHPVMPMKEIHESIRWTKDPRNTQDHVRSLCYLA 600
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 542 SFIDTNWENVTFLKRYFRADDQYPFLIHPVMPMKEIHESIRWTKDPRNTQDHVRSLCYLA 601
Qy 601 WHNGEEAYNEFCRKIRSVPVGRALTLPAYSSLRRKWLDSF 640
||||||||||||||||||||||||||||||||||||||||
Db 602 WHNGEEAYNEFCRKIRSVPVGRALTLPAYSSLRRKWLDSF 641
Prosecution Insights