Prosecution Insights
Last updated: July 17, 2026
Application No. 18/633,760

METHODS FOR REDUCING ISCHEMIA-REPERFUSION INJURIES

Non-Final OA §102
Filed
Apr 12, 2024
Priority
Apr 13, 2023 — provisional 63/495,891
Examiner
ROZOF, TIMOTHY R
Art Unit
1625
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Duke University
OA Round
1 (Non-Final)
73%
Grant Probability
Favorable
1-2
OA Rounds
0m
Est. Remaining
97%
With Interview

Examiner Intelligence

Grants 73% — above average
73%
Career Allowance Rate
697 granted / 960 resolved
+12.6% vs TC avg
Strong +24% interview lift
Without
With
+24.0%
Interview Lift
resolved cases with interview
Fast prosecutor
2y 0m
Avg Prosecution
49 currently pending
Career history
992
Total Applications
across all art units

Statute-Specific Performance

§101
1.0%
-39.0% vs TC avg
§103
23.8%
-16.2% vs TC avg
§102
27.9%
-12.1% vs TC avg
§112
21.2%
-18.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 960 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION This is a response to Applicant’s communication filed on July 8, 2024. Application No. 18/633,760, is a U.S. Nonprovisional application, filed April 12, 2024, and claims the benefit of U.S. Provisional application No. 63/495,891, filed April 13, 2023. In a preliminary amendment filed July 8, 2024, Applicant cancelled claims 11, 15, 16, 21-026, 28, 29, 31-40, and 42-56. Claims 1-10, 12-14, 17-20, 27, 30, and 41 are pending. Claim Rejections - 35 USC § 102(a)(1) The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1-10, 12-14, 17-20, 27, 30, and 41 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Batinic-Haberic et al., US2021/0361702 A1. Batinic-Haberic discloses a method of reducing an ischemia-reperfusion injury in a subject in need thereof, the method comprising: intra-arterially administering a redox active compound that comprises a metal to the subject, thereby reducing the ischemia-reperfusion injury in the subject. See Batinic-Haberic et al., US PG ‘702, p. 1, para. [0004], for the redox active compound BMX-001 (a.k.a. Mn2 or MnBuOE); see also Id., Fig. 1. For porphyrin derivatives of BMX-001 such as MnT-2-PyP+, MnTE-2-PyP5+, MnTnHex-2-PyP5+; see also p. 2, para. [0009], Formula I, for flouro-substituted (an electron-withdrawing or electron donating group substituted) porphyrin derivatives; see Id., p. 8, para. [0070]-[0071], for the uses of the porphyrin derivatives disclosed therein, including treating (reducing) an ischemia-reperfusion injury; see Id., p. 13-16, para. [0104]-[0146] for the route of administration and composition elements of the dependent claims. Conclusion No claims are allowed. Contact Information Any inquiry concerning this communication or earlier communications from the examiner should be directed to TIMOTHY R ROZOF whose telephone number is (571)270-5992. The examiner can normally be reached Monday - Friday, 9:00 a.m. -5:00 p.m.. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Andrew Kosar can be reached at (571) 272-0913. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /TIMOTHY R ROZOF/Primary Examiner, Art Unit 1625
Read full office action

Prosecution Timeline

Apr 12, 2024
Application Filed
Jun 09, 2026
Non-Final Rejection mailed — §102 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
73%
Grant Probability
97%
With Interview (+24.0%)
2y 0m (~0m remaining)
Median Time to Grant
Low
PTA Risk
Based on 960 resolved cases by this examiner. Grant probability derived from career allowance rate.

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