Prosecution Insights
Last updated: April 19, 2026
Application No. 18/651,293

BETA-ADRENERGIC AGONIST AND MUSCARINIC ANTAGONIST COMPOSITIONS AND METHODS OF USING

Non-Final OA §102
Filed
Apr 30, 2024
Examiner
MI, QIUWEN
Art Unit
1655
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Bonafide Health LLC
OA Round
1 (Non-Final)
68%
Grant Probability
Favorable
1-2
OA Rounds
2y 7m
To Grant
99%
With Interview

Examiner Intelligence

Grants 68% — above average
68%
Career Allow Rate
1065 granted / 1565 resolved
+8.1% vs TC avg
Strong +50% interview lift
Without
With
+50.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 7m
Avg Prosecution
41 currently pending
Career history
1606
Total Applications
across all art units

Statute-Specific Performance

§101
10.9%
-29.1% vs TC avg
§103
38.4%
-1.6% vs TC avg
§102
25.8%
-14.2% vs TC avg
§112
19.1%
-20.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1565 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Claims 1-30 are pending. Claims 1-30 are examined on the merits. Claim Objections Claim 5 recites “PG”, and Applicant is required to spell out the full chemical name of the PG. Claims 8, 9, 12, 13, 20, 23, 24, 27, and 28 are objected for the same reason; for failing to identify the abbreviated term. Claims 10, 11, 25, and 26 are objected for dependent upon the objected claims. Claims 2-4, 6, 7, 14, 15, 17-19, 21, 22, 29, and 30 are objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. Claim Rejections –35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale or otherwise available to the public before the effective filing date of the claimed invention. (a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention. Claims 1, and 16 are rejected under 35 U.S.C. 102 (a)(1) as being anticipated by Caltabianos et al (WO 2012018773 A1). Caltabianos et al teach NOVELTY - Combination comprises: (i) a beta-3 adrenergic receptor agonist and (ii) a muscarinic receptor antagonist (thus claim 1 is met). DESCRIPTION - An INDEPENDENT CLAIM is also included for treating at least one symptom associated with overactive bladder in a mammal (thus a method of supporting bladder health, thus claim 1 is met; thus identifying a subject experiencing or likely to experience overactive bladder or at least one symptom associated therewith, thus claim 16 is met), comprising administering to the mammal the combination of (i) and (ii). USE - The combination is useful in the treatment of: at least one symptom associated with overactive bladder in a mammal, where the symptoms comprise frequency of urgency, nocturia or urinary incontinence (all claimed); gastrointestinal syndromes e.g. irritable bowel syndrome, inflammatory bowel disease and ulcerative colitis; and cardiovascular diseases (see Abstract). Caltabianos et al teach pharmaceutical formulations adapted for oral administration may be presented as discrete units such as capsules or tablets; powders or granules; solutions or suspensions in aqueous or non-aqueous liquids, etc. (page 15, lines 3-5). Therefore, the reference is deemed to anticipate the instant claim above. Conclusion No claim is allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to QIUWEN MI whose telephone number is (571)272-5984. The examiner can normally be reached on Monday-Friday 8:30 am to 5:00 pm. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Anand Desai can be reached on 571-272-0947. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /Qiuwen Mi/ Primary Examiner, Art Unit 1655
Read full office action

Prosecution Timeline

Apr 30, 2024
Application Filed
Feb 25, 2026
Non-Final Rejection — §102 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
68%
Grant Probability
99%
With Interview (+50.0%)
2y 7m
Median Time to Grant
Low
PTA Risk
Based on 1565 resolved cases by this examiner. Grant probability derived from career allow rate.

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