Prosecution Insights
Last updated: April 18, 2026
Application No. 18/670,613

COMPOSITIONS AND METHODS FOR TREATMENT OF FUNGAL INFECTIONS

Final Rejection §DP
Filed
May 21, 2024
Examiner
HA, JULIE
Art Unit
1654
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
The University of Southern California
OA Round
2 (Final)
76%
Grant Probability
Favorable
3-4
OA Rounds
2y 8m
To Grant
99%
With Interview

Examiner Intelligence

Grants 76% — above average
76%
Career Allow Rate
831 granted / 1099 resolved
+15.6% vs TC avg
Strong +44% interview lift
Without
With
+44.3%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
44 currently pending
Career history
1143
Total Applications
across all art units

Statute-Specific Performance

§101
4.4%
-35.6% vs TC avg
§103
27.4%
-12.6% vs TC avg
§102
15.1%
-24.9% vs TC avg
§112
18.5%
-21.5% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1099 resolved cases

Office Action

§DP
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Amendment after Non-final office action filed on March 14, 2026 is acknowledged. Claims 12-13 have been cancelled. New claims 21-26 have been added. Claims 11 and 14-26 are pending in this application. Applicant elected the species of SEQ ID NO: 7 (GVCRCRRGVCRCRR), patients with inflammation and inhibits TACE activity in the reply filed on August 19, 2025. Because applicant did not distinctly and specifically point out the supposed errors in the restriction requirement, the election had been treated as an election without traverse (MPEP 818.01(a)). As indicated in the previous office action, claim 20 had been determined as a different invention, and claim 20 was withdrawn from consideration pursuant to 37 CFR 1.142(b), as being drawn to nonelected invention, there being no allowable generic or linking claim. Claims 11, 14-19 and 21-26 are examined on the merits in this office action. This application contains claim 20 drawn to invention nonelected in the response filed on 8/19/25. A complete reply to the final rejection must include cancellation of nonelected claims or other appropriate action (37 CFR 1.144). See MPEP § 821.01. Withdrawn Objections and Rejections Objection to claim 17 is hereby withdrawn in view of Applicant’s amendment to the claim. Rejection of claims 11-19 under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, is hereby withdrawn in view of Applicant’s amendment to the claims. Please note, the specification has not been checked to the extent necessary to determine the presence of all possible error. Applicant's cooperation is required in correcting any errors of which applicant may become aware in the specification. MPEP § 608.01. Maintained Rejection DOUBLE PATENTING The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP § 2146 et seq. for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The filing of a terminal disclaimer by itself is not a complete reply to a nonstatutory double patenting (NSDP) rejection. A complete reply requires that the terminal disclaimer be accompanied by a reply requesting reconsideration of the prior Office action. Even where the NSDP rejection is provisional the reply must be complete. See MPEP § 804, subsection I.B.1. For a reply to a non-final Office action, see 37 CFR 1.111(a). For a reply to final Office action, see 37 CFR 1.113(c). A request for reconsideration while not provided for in 37 CFR 1.113(c) may be filed after final for consideration. See MPEP §§ 706.07(e) and 714.13. The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The actual filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/apply/applying-online/eterminal-disclaimer. Claims 11, 14-19 and 21-26 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-11 of U.S. Patent No. 12,012,440. Although the claims at issue are not identical, they are not patentably distinct from each other because if one of ordinary skill in the art practiced the claimed invention of instant claims, one would necessarily achieve the claimed invention of US Patent claims, and vice versa. Please note: Instant application is a CON or US Patent No. 12,012,440. Therefore, the double patenting rejection is proper. Instant claims are drawn to: PNG media_image1.png 554 586 media_image1.png Greyscale . US Patent claims are drawn to: PNG media_image2.png 614 398 media_image2.png Greyscale PNG media_image3.png 592 396 media_image3.png Greyscale . Instant application is a CON of US Patent No. 12,012,440. Instant claims recite the method of treating or preventing disseminated fungal infection and associated septic shock in an individual comprising administering a cyclic peptide to the individual wherein the cyclic peptide is the same as US Patent claims, thus, the double patenting rejection is proper. Response to Applicant’s Arguments Applicant argues that, “Similar to the principles in Ex parte Baurin and Allergan, the claims of the pending application, if issued, would not extend beyond the patent term of the ‘440 patent, and thus, based at least on Ex parte Baurin, applying the principles of Allergan, Applicant respectfully submits that ’440 patent should not serve as a nonstatutory double patenting reference against the claims in the present application.” Applicant’s arguments have been fully considered but are not found persuasive. As instant application was filed as a CON of the issued patent, there is no 121 shield for instant application. Therefore, until a properly executed terminal disclaimer is filed and approved by the Office, Double Patenting rejection is proper and is maintained herein. CONCLUSION No claim is allowed. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to JULIE HA whose telephone number is (571)272-5982. The examiner can normally be reached Monday-Thursday 5:00 am- 6:30 pm EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, LIANKO GARYU can be reached at 571-270-7367. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JULIE HA/Primary Examiner, Art Unit 1654 4/2/2026
Read full office action

Prosecution Timeline

May 21, 2024
Application Filed
Sep 10, 2025
Non-Final Rejection — §DP
Mar 14, 2026
Response Filed
Mar 26, 2026
Examiner Interview (Telephonic)
Apr 07, 2026
Final Rejection — §DP (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12599646
PEPTIDE-CONTAINING COMPOSITION FOR USE FOR TREATING NEOPLASTIC LESIONS
2y 5m to grant Granted Apr 14, 2026
Patent 12599651
PHARMACEUTICALS AND DOSING MEANS FOR HUMAN AGING REVERSAL
2y 5m to grant Granted Apr 14, 2026
Patent 12564622
PREVENTING CYTOKINE RELEASE SYNDROME
2y 5m to grant Granted Mar 03, 2026
Patent 12551567
BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR PD-L1
2y 5m to grant Granted Feb 17, 2026
Patent 12551533
INTRANASAL NEUROPEPTIDES FOR USE IN STRESS-RELATED IMPAIRMENTS
2y 5m to grant Granted Feb 17, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
76%
Grant Probability
99%
With Interview (+44.3%)
2y 8m
Median Time to Grant
Moderate
PTA Risk
Based on 1099 resolved cases by this examiner. Grant probability derived from career allow rate.

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