DETAILED ACTION
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
According to paper filed on Sep. 18, 2026, the applicants have canceled claim 45 and furthermore, have amended claim 47.
Claims 1-2, 4, 7, 9, 12, 16, 18-19, 24, 33, 37-39, 42-43, 46-49 and 51-52 are pending in the application.
Response to Arguments
Applicants’ arguments filed Sep. 18, 2026 have been fully considered but they are not persuasive regarding indefinite rejection of claim 46 and both ODP rejections. Regarding indefiniteness rejection, the applicants argue on pages 56-57 that claim 46 is broad but not indefinite. The examiner does not agree with these arguments. Claim 46 is indefinite since diseases associated with either hyperactivity or hypoactivity of KRAS protein, are not defined. The diseases will be different based on hyperactivity or hypoactivity of KRAS protein. Regarding both ODP rejections, the applicants did not file either terminal disclaimer or amended claims to overcome these rejections.
Conclusion
Rejection of claim 46 under 35 U.S.C. 112, 2nd paragraph is maintained.
The ODP rejection of claims 1-2, 4, 7, 9, 12, 16, 19, 24, 33, 37-39 and 42 over U.S. Patent 12, 441,727 is maintained.
The ODP rejection of claims 1-2, 4, 7, 9, 12, 16, 19, 24, 33, 37-39, 42-43 and 46-49 over U.S. Patent 12, 600,717 is maintained.
NEW GROUNDS OF REJECTION
Claim Rejections - 35 USC § 112
8. The following is a quotation of 35 U.S.C. 112(b):
(b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention.
The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph:
The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention.
Claims 51 and 52 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention.
Claims 51 and 52 depend upon claim 45 which has been canceled.
Allowable Subject Matter
Claim 18 is objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims.
Applicants’ amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicants are reminded of the extension of time policy as set forth in 37 CFR 1.136(a).
A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action.
Any inquiry concerning this communication or earlier communications from the examiner should be directed to CHARANJIT AULAKH whose telephone number is (571)272-0678. The examiner can normally be reached Monday-Friday 7:00-3:30.
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If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Clinton A Brooks can be reached at 571-270-7682. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300.
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/CHARANJIT AULAKH/ Primary Examiner, Art Unit 1621
