Prosecution Insights
Last updated: September 17, 2026
Application No. 18/695,174

2,6-PIPERIDINEDIONE COMPOUND AND APPLICATION THEREOF

Non-Final OA §Other
Filed
Mar 25, 2024
Priority
Sep 26, 2021 — CN 202111131041.0 +2 more
Examiner
MCDOWELL, BRIAN E
Art Unit
1624
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Zhangzhou Pien Tze Huang Pharmaceutical Co. Ltd.
OA Round
1 (Non-Final)
74%
Grant Probability
Favorable
1-2
OA Rounds
0m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 74% — above average
74%
Career Allowance Rate
841 granted / 1134 resolved
+14.2% vs TC avg
Strong +31% interview lift
Without
With
+30.6%
Interview Lift
resolved cases with interview
Typical timeline
2y 2m
Avg Prosecution
71 currently pending
Career history
1183
Total Applications
across all art units

Statute-Specific Performance

§101
1.0%
-39.0% vs TC avg
§103
16.4%
-23.6% vs TC avg
§102
20.5%
-19.5% vs TC avg
§112
49.7%
+9.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1134 resolved cases

Office Action

§Other
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION RESPONSE TO ELECTION/RESTRICTION Applicant's election with traverse of group I, drawn to compounds of the formula II and simple compositions thereof and elected species: PNG media_image1.png 118 380 media_image1.png Greyscale in the reply filed on 7/15/2026 is acknowledged. The traversal is on the ground(s) that unity of invention is present due to the claims embracing a product and method of use (see page 25 of arguments). This is not found persuasive because the latter criteria is assumed only if there are no other outstanding issues that would render the claims to not have unity of invention. As described in the restriction requirement, the instantly claimed compounds encompass a myriad of heterocyclic functionalities that do not share a common chemical structure (e.g. formula II). Furthermore, due to their divergent structural nature, one having ordinary skill in the art would presume that when substituted into the formula II, each individual heterocycle as a “whole” (not focusing on one particular variable such as L) would not function in the same manner to give the same intended result. Therefore, these claims can be said to lack unity a priori as there is no technical feature common to all the claims. The requirement is still deemed proper and is therefore made FINAL. Claims 16-19 are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being drawn to a nonelected invention, there being no allowable generic or linking claim. An action on the merits of claims 1, 7-10, and 12-15 is contained herein. Applicant’s elected species was found free of the art and the full scope of formula II searched. Priority This application is a U.S. National Phase Application under 35 U.S.C. 371 of International Application No. PCT/CN2022/120267, filed on September 21, 2022, which claims 1) the priority and rights of Chinese Patent Application No. 2021111310410 submitted to CNIPA on September 26, 2021, and 2) the priority and rights of Chinese Patent Application No. 2022111046982 submitted to CNIPA on September 9, 2022. However, a certified English version of the foreign priority documents were not received. Failure to provide a certified translation may result in no benefit being accorded for the non-English application (i.e., the examiner respectfully requests submission of the appropriate English translated version of the foreign priority document if benefit is sought). See MPEP 213.04. Information Disclosure Statement The examiner has considered the references cited in the information disclosure statement filed of record. Claim Objections Claims 1, 7-10, and 12-15 are objected to because of the following informalities: In claim 1 and other claims, the manner in which the dashed lines (e.g. see TIRAK) are attached to the other segments of the molecule should be articulated (e.g. wherein the dotted/dashed lines represent a bond to variable L, etc.). Thus, the claim and claims dependent on it are objected to. Correction is required. The preamble of claims 12-14 should incorporate proper Markush language such as “wherein the compound is selected from the group consisting of..”. Correction is required. Conclusion No claims are allowed. However the claimed compounds appear to be neither anticipated nor rendered obvious over the art. There is no relevant art to be put on record by the examiner with respect to the latter. Any inquiry concerning this communication or earlier communications from the examiner should be directed to BRIAN E MCDOWELL whose telephone number is (571)270-5755. The examiner can normally be reached on 8:30-6 MF. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Jeffrey Murray can be reached at 571-272-9023. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRIAN E MCDOWELL/Primary Examiner, Art Unit 1624
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Prosecution Timeline

Mar 25, 2024
Application Filed
Aug 25, 2026
Non-Final Rejection mailed — §Other (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
74%
Grant Probability
99%
With Interview (+30.6%)
2y 2m (~0m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1134 resolved cases by this examiner. Grant probability derived from career allowance rate.

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