Prosecution Insights
Last updated: April 19, 2026
Application No. 18/697,480

COSMETIC COMPOSITION COMPRISING BELUGA CAVIAR EXOSOMES AS ACTIVE INGREDIENTS FOR REDUCING WRINKLES, IMPROVING MOISTURIZATION, AND IMPROVING SKIN BARRIERS

Non-Final OA §101
Filed
Mar 31, 2024
Examiner
GULLEDGE, BRIAN M
Art Unit
1699
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Cosmax Inc.
OA Round
1 (Non-Final)
55%
Grant Probability
Moderate
1-2
OA Rounds
3y 3m
To Grant
82%
With Interview

Examiner Intelligence

Grants 55% of resolved cases
55%
Career Allow Rate
521 granted / 942 resolved
-4.7% vs TC avg
Strong +26% interview lift
Without
With
+26.5%
Interview Lift
resolved cases with interview
Typical timeline
3y 3m
Avg Prosecution
24 currently pending
Career history
966
Total Applications
across all art units

Statute-Specific Performance

§101
0.9%
-39.1% vs TC avg
§103
49.2%
+9.2% vs TC avg
§102
15.2%
-24.8% vs TC avg
§112
20.4%
-19.6% vs TC avg
Black line = Tech Center average estimate • Based on career data from 942 resolved cases

Office Action

§101
DETAILED ACTION AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. Election/Restrictions Applicant’s election without traverse of Group I (claims 1-4) in the reply filed on 25 December 2025 is acknowledged. Claim 5 is withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Claims 1-4 are rejected under 35 U.S.C. 101 because the claimed invention is directed to a judicial exception (i.e., a law of nature, a natural phenomenon, or an abstract idea) without significantly more. The analysis set forth for evaluating subject matter eligibility under section 101 is discussed in MPEP 2106. Step 1 is to determine if the claim is to a process, machine, manufacture, or a composition of matter. For the instantly recited invention, this is true. The claims are directed to a cosmetic composition comprising exosomes derived from beluga caviar, and thus are directed to a composition of matter. Thus, the analysis continues to step 2A. Step 2A consists of two prongs. The first prong of step 2A is if the claim recites an abstract idea, a law of nature, or a natural phenomenon. The claims are directed to a natural phenomenon. More specifically, the exosomes derived from beluga caviar. As stated by the instant specification, exosomes are secreted from all cells (paragraph [3]), and thus the exosomes from beluga caviar are products of nature. Thus, the claims are drawn to a natural phenomenon, and the analysis continues to the second prong of step 2A. The second prong of step 2A is does the claim recite additional elements that integrate the judicial exception into a practical application. The claims are directed to a cosmetic composition comprising exosomes derived from beluga caviar, and there is no elements recited as limitations which integrate the exosomes into a practical application. Thus, as there is nothing else in the claim other than the judicial exception, the analysis continues to step 2B. Step 2B is does the claim recite additional elements that amount to significantly more than the judicial exception. And the instant claims do not include additional elements that are sufficient to amount to significantly more than the judicial exception because the only components listed are the naturally occurring ingredients. The only additional limitations are that the composition is a cosmetic composition. But there is no limitation to the claimed invention requiring anything which is not drawn to a judicial exception. And there is nothing in the specification to indicate that exosome compositions have any additional functionality beyond that which it has individually. Example 1 prepares exosomes, which are dispersed in water, and the water dispersed exosomes alone are a cosmetic composition (experiment example 1). Thus, the claims are considered to not be drawn to eligible subject matter under 35 USC 101. Comment Regarding Subject Matter The composition of claim 1 is free of the prior art. The claimed invention recites a cosmetic composition comprising exosomes derived from beluga caviar. The closest prior art is considered US Patent Application Publication 2017/0152484. This document discloses exosomes for treating the skin to address wrinkles (abstract & paragraph [2]), so it does disclose exosomes for a cosmetic composition. However, this reference does not disclose preparing exosomes from the same source as in the claimed invention (beluga caviar). And there is no suggestion to use caviar for the preparation of exosomes for cosmetic compositions. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to Brian Gulledge whose telephone number is (571) 270-5756. The examiner can normally be reached Monday - Friday 7am - 4pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Fereydoun Sajjadi can be reached at (571) 272-3311. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /Brian Gulledge/Primary Examiner, Art Unit 1699
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Prosecution Timeline

Mar 31, 2024
Application Filed
Jan 25, 2026
Non-Final Rejection — §101 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12599677
TARGETED PH SENSITIVE LIPOSOMES
2y 5m to grant Granted Apr 14, 2026
Patent 12589183
HEMOSTATIC PASTE AND USES THEREOF
2y 5m to grant Granted Mar 31, 2026
Patent 12576017
SUNSCREEN COMPOSITION WITH ENHANCED PHOTOPROTECTION
2y 5m to grant Granted Mar 17, 2026
Patent 12569371
STERILIZATION OF MEDICAL DRESSINGS WITH ENHANCED ANTIMICROBIAL PROPERTIES
2y 5m to grant Granted Mar 10, 2026
Patent 12569461
THERAPEUTIC SUPPLEMENT
2y 5m to grant Granted Mar 10, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
55%
Grant Probability
82%
With Interview (+26.5%)
3y 3m
Median Time to Grant
Low
PTA Risk
Based on 942 resolved cases by this examiner. Grant probability derived from career allow rate.

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