Prosecution Insights
Last updated: April 19, 2026
Application No. 18/702,419

ESTIMATION OF BLOOD PRESSURE IN THE HEART

Non-Final OA §101
Filed
Apr 18, 2024
Examiner
BRUTUS, JOEL F
Art Unit
3797
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
King'S College London
OA Round
1 (Non-Final)
72%
Grant Probability
Favorable
1-2
OA Rounds
3y 7m
To Grant
90%
With Interview

Examiner Intelligence

Grants 72% — above average
72%
Career Allow Rate
922 granted / 1276 resolved
+2.3% vs TC avg
Strong +18% interview lift
Without
With
+18.0%
Interview Lift
resolved cases with interview
Typical timeline
3y 7m
Avg Prosecution
48 currently pending
Career history
1324
Total Applications
across all art units

Statute-Specific Performance

§101
5.9%
-34.1% vs TC avg
§103
47.7%
+7.7% vs TC avg
§102
14.9%
-25.1% vs TC avg
§112
23.6%
-16.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1276 resolved cases

Office Action

§101
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . The set of claim filed on 4/18/2024 is being considered. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Claims 1-17 are rejected under 35 U.S.C. 101 because the claimed invention is directed to estimating LV filling pressure of the heart of a human without significantly more. The claims (1, 11, 14) recite(s): (a) use the imaging data to obtain cardiac markers including an estimate of LA reservoir strain and an estimate of the time constant of LV isovolumic pressure decay, and use the patient specific parameters directly or to determine additional cardiac markers including systolic pressure and BMI; (b) determine an estimate of the minimum LV diastolic pressure as a summation of a value derived from each of the cardiac markers multiplied by a corresponding constant of proportionality and added to a constant value, wherein the constant value and the various constants of proportionality have been derived from a statistical analysis of historic patient data (c) estimate the peak pressure drop during early diastole between left atrium over left ventricle and hence obtaining a maximum difference between the LA pressure and LV pressure; (d) calculate an estimate of LV filling pressure as the sum of values from step (b) and step (c) above. This judicial exception is not integrated into a practical application because the steps for “receiving”, “estimating”, “calculating” data amount(s) to nothing more than routine data collection and/or insignificant extra-solution activity, i.e. the mere collection of data (regardless of the source of said data) is NOT an inventive concept. Without additional limitations, a process that employs mathematical algorithms to manipulate existing information to generate additional information is not patent eligible. If a claim is directed essentially to a method of calculating/estimating, using a mathematical formula, even if the solution is for a specific purpose, the claimed method is nonstatutory. Additionally, even though the information provided to the user may in fact be “actionable information”, this does not change the fact that it is still merely information and the instant claims do not require any structural and/or positive process limitations that occur outside of a computer environment. Therefore, the “intended use” of the information by the user does not have any limiting effect on the claimed device and does not amount to “significantly more” than the abstract idea. The claim(s) does/do not include additional elements that are sufficient to amount to significantly more than the judicial exception because: With regard to the associated "computer program product", and "imaging system", as set forth above, these are recited at a high level of generality and perform nothing more than well-understood, routine, and conventional activities previously known to the industry. Similarly, the claimed “data processing device” is nothing more than a nominal recitation of a computer covering an abstract concept, which is insufficient to make a claim patent eligible. Claims 2-10 and 15-16 are rejected for the same reasons because they depend on claim 1, 11 and 14. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to JOEL F BRUTUS whose telephone number is (571)270-3847. The examiner can normally be reached Mon-Sat, 11:00 AM to 7:00 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Pascal Bui-Pho can be reached at 571-272-2714. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JOEL F BRUTUS/Primary Examiner, Art Unit 3798
Read full office action

Prosecution Timeline

Apr 18, 2024
Application Filed
Feb 07, 2026
Non-Final Rejection — §101 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
72%
Grant Probability
90%
With Interview (+18.0%)
3y 7m
Median Time to Grant
Low
PTA Risk
Based on 1276 resolved cases by this examiner. Grant probability derived from career allow rate.

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