Prosecution Insights
Last updated: October 21, 2026
Application No. 18/709,230

IMMUNOREACTIVE MOLECULES AND USES THEREOF

Non-Final OA §112
Filed
May 10, 2024
Priority
Nov 11, 2021 — EU 21207828.1 +1 more
Examiner
NICKOL, GARY B
Art Unit
1643
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Karsten Warwas
OA Round
2 (Non-Final)
47%
Grant Probability
Moderate
2-3
OA Rounds
1y 4m
Est. Remaining
80%
With Interview

Examiner Intelligence

Grants 47% of resolved cases
47%
Career Allowance Rate
34 granted / 73 resolved
-13.4% vs TC avg
Strong +33% interview lift
Without
With
+33.3%
Interview Lift
resolved cases with interview
Typical timeline
3y 9m
Avg Prosecution
53 currently pending
Career history
121
Total Applications
across all art units

Statute-Specific Performance

§101
3.8%
-36.2% vs TC avg
§103
22.3%
-17.7% vs TC avg
§102
22.3%
-17.7% vs TC avg
§112
37.6%
-2.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 73 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claims 1-9, 11, and 16-20 are pending and under consideration. Information Disclosure Statement Reference CH (Schilling et al.) was not considered as it was not in English. See MPEP 609.01 (B)(3) or 37 CFR 1.98. Specification The disclosure is objected to (e.g., page 12) because it contains an embedded hyperlink and/or other form of browser-executable code. Applicant is required to delete the embedded hyperlinks and/or other form of browser-executable codes; references to websites should be limited to the top-level domain name without any prefix such as http:// or other browser-executable code. See MPEP § 608.01. Drawings Figure 2 is objected to because for recitation of amino acid sequences in the absence of a sequence identifier. See 37 CFR 1.821(c). 37 CFR 1.821(c) requires that patent applications which contain disclosures of nucleotide and/or amino acid sequences that fall within the definitions of 37 CFR 1.821(a) must contain a "Sequence Listing," as a separate part of the disclosure, which presents the nucleotide and/or amino acid sequences and associated information using the symbols and format in accordance with the requirements of 37 CFR 1.821 - 1.825. Claim Objections Claim 1 is confusing because there is a large blank space in the second to last line. This is confusing because it separates the recitation of the CDRs sequence identifiers. The preference is that applicants amend the last line and move “to 7.” so that it appears as: “SEQ ID NOs:5 to 7”. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 5-6, and 8 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Regarding claims 5-6, 8 the phrases "preferably," or “more preferably” or “even more preferably” renders the claim indefinite because it is unclear whether the limitation(s) following the phrase are actually part of the claimed invention. As such, these phrases create ambiguity as to whether or not the alternatives are distinct limitations. See MPEP § 2173.05(d). Allowable Subject Matter Claims 1-4, 9, 11, and 16-20 are allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to GARY B NICKOL, Ph.D. whose telephone number is (571)272-0835. The examiner can normally be reached M-F 9AM-5:30PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Julie Wu can be reached at 571-272-5205. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /GARY B NICKOL/Primary Examiner, Art Unit 1643
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Prosecution Timeline

May 10, 2024
Application Filed
Sep 28, 2026
Non-Final Rejection mailed — §112
Oct 15, 2026
Applicant Interview (Telephonic)
Oct 19, 2026
Non-Final Rejection mailed — §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
47%
Grant Probability
80%
With Interview (+33.3%)
3y 9m (~1y 4m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 73 resolved cases by this examiner. Grant probability derived from career allowance rate.

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